Five Technion Researchers Receive Israel Cancer Research Fund Grants - הטכניון-מכון טכנולוגי לישראל

technion.ac.il

Coexistence of Photosynthetic Marine Microorganisms, Viruses and Grazers: Towards Integration in Ocean Ecosystem Models

Our study explores coexistence regimes of a virus and a zooplankton with a single phytoplankton for different model structures (left panel). The inclusion of an infected class and a resistant class i...

enviromicro-journals.onlinelibrary.wiley.com

2026 Daniel Shiran Prize Awarded to Dr. Noga Ron-Harel of the Technion Faculty of Biology - הטכניון-מכון טכנולוגי לישראל

technion.ac.il

Tunable kinetic destabilization governs RNA polymerase passage through a DNA-bound transcription factor

Eukaryotic transcription factors recognize short motifs, creating abundant binding sites within gene bodies and potential collisions with elongating RNA polymerases, yet how such encounters are resolved remains unclear. Here, we use optical tweezers to monitor RNA polymerase transcription through DNA-bound Egr-1, a zinc-finger transcription factor. Using DNA-fluctuation suppression as a readout of polymerase arrival, we show that Egr-1 delays elongation in an orientation- and rNTP-dependent manner, whereas force measurements indicate that RNAP does not bypass the TF by mechanical eviction. Instead, RNAP destabilizes the Egr-1-DNA complex over a short, structured interaction zone, increasing TF dissociation non-monotonically with distance. Monte Carlo simulations incorporating these kinetic changes recapitulate passage-time distributions. CpG methylation shortens Egr-1 residence time and largely eliminates the TF-dependent delay, suggesting a role for gene-body methylation in reducing kinetic barriers to elongation. These results reveal DNA-bound TFs as tunable barriers that locally shape transcription elongation. ### Competing Interest Statement The authors have declared no competing interest. Israel Science Foundation, https://ror.org/04sazxf24

biorxiv.org

The Fast Track to Antibiotic Resistance - הטכניון-מכון טכנולוגי לישראל

technion.ac.il

Career Development Award for Sheila Roitman

bio.mpg.de

A complete set of canonical nucleobases in the carbonaceous asteroid (162173) Ryugu - Nature Astronomy

Samples returned from the asteroid Ryugu contain all five canonical nucleobases (A, G, C, T and U). Their presence in Ryugu and Bennu supports the hypothesis that carbonaceous asteroids contributed to...

nature.com

Compact Spectral Encoding Microscopy by Terrace Grating Optics

Spectral information is essential in microscopy, yet many multispectral imaging solutions require increased optical complexity or restrict the spectrum to a few discrete bands. In this work we introdu...

pubs.acs.org

The twisted tale of cotranslational protein complex assembly

Macromolecular complexes are cells’ functional units, and their correct and efficient assembly is critical to life’s processes. Complex assembly was c…

sciencedirect.com

Deep learning on histopathological images to predict breast cancer recurrence risk and chemotherapy benefit: a multicentre, model development and validation study

These findings show that AI applied to routine histopathology can serve as a practical and scalable tool for guiding chemotherapy decisions in hormone receptor-positive, HER2-negative, early breast ca...

thelancet.com

פרופ' דבי לינדל מהטכניון נבחרה לארגון האירופי לביולוגיה מולקולרית (EMBO) - הטכניון-מכון טכנולוגי לישראל

technion.ac.il

Non-canonical gene amplifications facilitate adaptive evolution in bacteria - Nature Microbiology

Transposon-associated amplifications are dominated by a previously underappreciated architecture, where the transposon is found only between, not flanking, the amplicons. These amplifications facilita...

nature.com

Making Waves in Marine Science: Prof. Debbie Lindell Elected to EMBO - פקולטה לביולוגיה Biology Faculty

We are proud to share that Prof. Debbie Lindell has been elected as a member of the European Molecular Biology Organization (EMBO), one of the highest honors in the life sciences. EMBO membership reco...

biology.technion.ac.il

Brassinosteroid signaling regulates shoot apical meristem homeostasis via orchestrating cytokinin and WUSCHEL activity

BR synergizes with cytokinin to enhance WUS activity for SAM maintenance and prevents SAM arrest by repressing FRUITFUL.

science.org