Acquisition of a gene cluster in Clostridioides difficile PCR ribotype 023 strains enables xylitol utilization | mSphere journals.asm.org/doi/10.1128/...

Acquisition of a gene cluster in Clostridioides difficile PCR ribotype 023 strains enables xylitol utilization | mSphere

Genetic factors aiding in the emergence of the opportunistic pathogen Clostridioides difficile are poorly understood. Infections with clade 3 (PCR ribotype 023) strains causing severe disease have increased since 2008. Here, we show RT023 strains have the unique ability to utilize xylitol, a sugar alcohol used as a food additive in humans and animals, due to the presence of a xylitol dehydrogenase (xdh) gene within a mobile genetic element (MGE). This xylitol utilization ability confers a fitness benefit in competition against other C. difficile ribotypes, as well as in a fecal community in vitro. Research investigating the underlying genetic factors driving the physiology of C. difficile will improve our understanding of colonization and hypervirulence.

journals.asm.org

journals.asm.org/doi/10.1128/...

Effects of improved water, sanitation, handwashing, and nutrition on early childhood IgG immune repertoire development against Shigella and enteroinvasive Escherichia coli (EIEC) | mSphere

Shigella/EIEC is a leading cause of global diarrheal deaths, especially in low-resource settings. Current interventions against childhood Shigella/EIEC infection focus on reducing exposure, such as th...

journals.asm.org

journals.asm.org/doi/10.1128/...

Emerging pathogens in urinary tract infections: virulence and phenotypic characterization of Pseudomonas aeruginosa strains | mSphere

Pseudomonas aeruginosa is an emerging but understudied pathogen in urinary tract infections (UTIs). Given its resilience, adaptability, and the growing threat of multidrug resistance, P. aeruginosa re...

journals.asm.org

Interesting timeline this morning. Did Trump kill that toad to make that tie?

@buffalo-bills.bsky.social training camp opens tomorrow. New season means that it's time to move on. #Billsmafia

Had so much fun writing this commentary for #msphere! Grateful for the opportunity to write about work that’s shaped my perspective on innate immunity and RNA virus infection journals.asm.org/doi/10.1128/...

mSphere of Influence: Damage in RNA virus infection—a feature or a bug? | mSphere

How does the body recognize viral infection? How do viruses engage the immune system during replication? These seemingly simple questions led me to study pattern recognition, a concept first proposed ...

journals.asm.org

JB Editor's Pick: Roberts, Sandkvist et al. examine the role of the GlyGly-CTERM domain in the section/membrane association of T2SS-secreted proteins. journals.asm.org/doi/10.1128/... @asm.org #JBacteriol @microsky.bsky.social

Oh wow, really nice work from Scott Dawson's lab!

American Society for Cell Biology@ascbiology.bsky.social · 2w ago

From MBoC A new localization atlas maps more than 600 Giardia proteins, revealing the locations of hundreds of previously uncharacterized proteins and creating a valuable resource for functional discovery. https://www.molbiolcell.org/doi/10.1091/mbc.E25-12-0590

I want to welcome mSphere's newest Senior Editor @davislabjhu.bsky.social. Kim is an outstanding bacteriologist whose lab is doing ground-breaking research focused on bacterial heterogeneity within a culture and how this contributes to pathogenesis and antimicrobial resistance. @asm.org #mSphere

Postdoc opening in the Laboratory of Neurotrauma Research in the College of Veterinary Medicine at Virginia Tech. Work will focus on murine models of brain injury and innate immune regulation. Excellent employee benefits. Apply by Aug. 3rd for full consideration! jobs.apply.vt.edu/jobs/postdoc...

Postdoctoral Associate - Blacksburg, Virginia, United States

Job Description The Laboratory of Neurotrauma Research at Virginia Tech is looking for highly motivated Postdoctoral Associates with expertise in Molecular and Cellular Neurobiology, TBI/SCI or Immu...

jobs.apply.vt.edu

This video is a metaphor for what DSA is all about. Sure he’s climbing up a rock wall which is challenging. But the safety rope that he’s attached to limits any sort of consequences and accountability

Abdul El-Sayed@abdulelsayed.bsky.social · 3w ago

Do we want a politics that's rigged by corporations, by special interests, and AIPAC? Or do we want a politics that delivers for all of us, the people, so that we can climb together to the heights that we all deserve?

France hasn’t given up this quickly since WWII

A lab full of England fans broken like a -80 when the compressor dies

#mSphere started a new article collections titled mSphere Legacy. These articles will be authored by our senior colleagues in the microbial sciences community to not only reflect back on their own careers and journey's but how they see the future unfolding. @asm.org journals.asm.org/eprint/PZEHP...

mSphere Legacy: Sharing wisdom at the culmination of a scientific career | mSphere

“We will be known forever by the tracks we leave.”

journals.asm.org

Wings save lives. It's SCIENCE.

I’m a scientist and I approve this message.

Andrew Galarneau@buffalofood.bsky.social · 3w ago

Wings save lives. It's SCIENCE.

Just added a couple more job apps (thanks Rachel and Arun!) but if you've gotten a job in industry, academia (R1, PUI, whatever!) in the last 5 years or so, please consider submitting your job app materials to help other folks! github.com/RILAB/statem...

GitHub - RILAB/statements: Successful Job Applications and Grants

Successful Job Applications and Grants. Contribute to RILAB/statements development by creating an account on GitHub.

github.com

Congratulations to @asm.org #mSphere newest editors. Thank you for doing this extremely important work in handling the wonderful papers authors submit to us our authors and ensuring that our readers have access to the best science. Very excited to begin working with each of you.

As we gear up for another NFL season, I hope that the referees watch this to see and learn what a Buffalo not making a catch really looks like #billsmafia youtu.be/aIiMSCBHThA?...

Bison Flips Grandpa In Yellowstone National Park

YouTube video by Cowboy State Daily

youtu.be

Today, I learned that my former Battalion Commander passed away. I learned a lot about leadership from Avi. Most important was to make everyone, even a lowly sergeant like me feel seen, heard, and important. יהי זיכרו ברוך

Bye 🇨🇭 I will miss your coach doing the best Starsky imitation

My son went to a @mets.com game last night. Any way, if anyone wants to adopt a 24 yo my DMs are open.

here’s the problem with belgium. Their whole cuisine is centered on mayonnaise being the perfect condiment for fries. So its hard: mayo ⚖️ corruption A real Sophie’s choice

@sanders.senate.gov I thibk you wear this tweet as a badge of honor and post it on everyone of your social media pages

Wanna know the real problem with American politics? There are no consequences for scum like this. On either side of the political spectrum

New in JB: Song, Qiao et al. show that the RmaH regulators balances Abx-R vs. acid-R by controlling cell wall thickness and membrane biogenesis vs. expressing the arginine deiminase pathway two RmaH-specific DNA-binding motifs. journals.asm.org/doi/10.1128/... @asm.org #JBacteriol #MicroSky

Canada is offsides so much the US may want to increase border security #worldcup

Get a pool for a Newfie, they said, Newfies are water dogs. Problem is that someone didn’t get the memo