Bruce Levine, Ph.D. 🇺🇦
@bllphd.bsky.social
🧬🧪Professor @Pennmedicine #CellTherapy #Genetherapy #Inventor #Kymriah #CARTCell @TmunityTx & @CapstanTx CoFounder, Past President @ISCTGlobal @PNASNexus AE https://orcid.org/0000-0001-6971-8465
We are actively looking to partner with biotech, pharma, and academic groups If you are advancing a program and need a partner who understands both the science and the realities of clinical translation, we should connect www.med.upenn.edu/cvpf/
Clinical Cell and Vaccine Production Facility (CVPF) | Clinical Cell and Vaccine Production Facility (CVPF) | Perelman School of Medicine at the University of Pennsylvania
med.upenn.edu
We’ve built an integrated platform designed to move programs from discovery into first-in-human studies with rigor, speed, and quality. What differentiates this model is not a single capability, but the integration: • Manufacturing • Process development • QC analytics and correlative science
Heading to the @isctglobal.bsky.social l Annual Meeting in Dublin? Come visit us at the Penn Medicine Clinical Cell and Vaccine Production booth 2505 1st Floor The Liffey across from ISCT Hub and meet our Facilities, Analytics, Operations, Regulatory and Manufacturing Experts.
Heading to the @isctglobal.bsky.social l Annual Meeting in Dublin? Come visit us at the Penn Medicine Clinical Cell and Vaccine Production booth 2505 1st Floor The Liffey across from ISCT Hub and meet our Facilities, Analytics, Operations, Regulatory and Manufacturing Experts.
NEW - Data-informed optimization of CAR T-cell therapy long-term follow-up At >60K patients treated, CAR-T LTFU is due for a reset. AEs are infrequently reported >3 years post-infusion, so 5 years is more appropriate considering low risk, cost burden, burdens on patients jitc.bmj.com/content/14/4...
Join us for the CAR T Scientific Signature Series event May 9 in Dublin @isctglobal.bsky.social Annual Meeting www.isctglobal.org/annual-meeti...
🚨NEW FDA Draft Guidance Safety Assessment of Genome Editing in Human Gene Therapy Products Using Next-Generation Sequencing #FDA #Regulatory #geneediting #genetherapy Top 5 Takeaways in reply www.fda.gov/regulatory-i...
Safety Assessment of GE in Human Gene Therapy Products Using NGS
This is the draft guidance for industry, Safety Assessment of Genome Editing in Human Gene Therapy Products Using Next-Generation Sequencing
fda.gov
What the peptide craze reveals about Americans’ relationship with risk. Great piece from @sarah-todd.bsky.social www.statnews.com/2026/04/06/r... It's so odd how many people will not trust proven biomedical approaches but embrace and literally shoot up with unproven things like peptides
What the peptide craze reveals about Americans’ relationship with risk
Why do RFK Jr. and other health influencers embrace unproven peptides while calling for more research into well-studied vaccines?
statnews.com
Celebrating innovation at @upenn.edu ft. @marcoruella.bsky.social, Saar Gill, Stephen Schuster (@penncancer.bsky.social), Carl June, @bllphd.bsky.social (@pennpathlabmed.bsky.social), Mark Engleka, Michael Yocum (PennPCI), Nicola Mason (Penn Vet) & Liang Feng (SEAS) tinyurl.com/mryfmk7u
🚨Congratulations to Prof. Dr. Carl June & Prof. Dr. Michel Sadelain! 2025 laureates of the Broermann Medical Innovation Award for the development of the CAR-T cell #immunotherapy #cancer #CancerResearch pressreleasehub.pa.media/article/dr-c...
DR. CARL JUNE AND DR. MICHEL SADELAIN ARE BEING AWARDED THE BROERMANN MEDICAL INNOVATION AWARD 2025
Giessen (ots) - - With prize money of one million euros, it is one of the most highly endowed medical awards in the world
pressreleasehub.pa.media
Is Germline Editing Feasible and Should it be Permissible? I joined @urnov.bsky.social, @kiranmusunuru.bsky.social, ISCT President Miguel Forte & Chief Regulatory Officer Bambi Grilley to discuss #ethics #bioethics & technological hurdles of embryo editing www.isctglobal.org/telegrafthub...
My CNBC.com segment on implications for pediatric vaccine schedule from recent politics. 2003 saw ~5,000 cases of pertusis, in 2024 there were over 35,000, and for 2025, some models show 70,000+ We risk a return of communicable diseases in children. www.youtube.com/watch?v=00cI...
How future cures begin as ideas in laboratories ft. Carl June, @bllphd.bsky.social (@pennpathlabmed.bsky.social), David Porter, Stephen Bagley, Jakub Svoboda (@penncancer.bsky.social) & Donald O'Rourke (@PennNSG) tinyurl.com/32hd7y2m
🚨Just published - Multiplex engineering using microRNA-mediated gene silencing in CAR T cells #celltherapy #genetherapy #immunotherapy www.frontiersin.org/journals/imm...
Announcing the website for the song Ring That Bell 🔔 cowritten w @magsmccarthy.bsky.social an emotional story of a cancer patient facing relapse and the fierce advocacy, support, and groundbreaking science that offer new hope. #cancer #cancerresearch #immunotherapy #hope ringthatbellsong.com
Nearly two dozen people developed food poisoning in Florida after consuming tainted raw milk from the same farm, state health department says (from @reportergoodman.bsky.social) www.cnn.com/2025/08/05/h...
Nearly two dozen people in Florida are ill after drinking raw milk from the same farm | CNN
Nearly two dozen people have developed food poisoning in Florida after consuming tainted raw milk from the same farm, according to the state’s Department of Health.
cnn.com
🚨Coming soon! Multiplex engineering using microRNA-mediated gene silencing in CAR T cells. In a single lentiviral vector- multiplex silencing & expression of a CAR, better expansion & viability than gene editing by electroporation www.frontiersin.org/journals/imm...
Frontiers | Multiplex engineering using microRNA-mediated gene silencing in CAR T cells
Multiplex gene edited CAR T cell therapies face challenges, including potential oncogenic risks from double-strand breaks. Targeted microRNAs (miRNAs) may of...
frontiersin.org
My new 2-minute 5-point short on why one shouldn't go to stem cell clinics or at least seriously weigh risks + low chance of benefit. Good little video for scientists and physicians too looking for clear explanation when people ask #stemcells #stemcell www.youtube.com/shorts/EX9iU...
5 reasons not to go to a stem cell clinic
YouTube video by The Stem Cell Channel from The Niche
youtube.com
Cutting NIH to “save” money is fundamentally flawed -Modest annual savings pale compared to multi‑trillion‑dollar health, innovation, and productivity losses www.statnews.com/2025/07/28/n...
New analysis predicts sprawling effects of proposed NIH budget cuts
Initial analyses of the Trump administration’s proposed NIH cuts neglect key aspects of their long-term economic and health impact, study says.
statnews.com
From Pink Sheet on continued departures from FDA’s biologics division and challenges backfilling openings. FDA biologics center reported 106 departures from Jan. 1 to June 30. These numbers don’t include the 100-150 who were part of the reduction-in-force insights.citeline.com/pink-sheet/a...
US FDA’s Biologics Center Departures Grew Before More Than 100 RIFs Exited
The Center for Biologics Evaluation and Research saw departures far outnumber new hires in the second and third quarters of FY 2025, before more than 100 people left July 14 after the reduction-in-for...
insights.citeline.com
FDA’s cancer review team overseeing breast and gynecological products has lost about 1/3 of its medical review staff and the malignant heme group will lose about 2/3 of its medical review staff—all to voluntary resignations clustered among seasoned reviewers insights.citeline.com/pink-sheet/a...
There should be a cable channel fact checking all the cable news channels and their paid "pundits" in real time
KFF Health News@kffhealthnews.org · last yr.CNN pundit Scott Jennings said almost 5 million nondisabled Medicaid recipients “simply choose not to work” and “spend six hours a day socializing and watching television.” KFF Health News + @politifact.bsky.social rate this statement False. Read why. ⤵️ kffhealthnews.org/news/article...
If gifted narrative filmmaker Marwin Gansauge asks, "Can I make a movie about you?", what do you say? More than ever, science communication is desperately needed to convey the importance of research in developing new treatments for patients. Filmed in Vancouver & Dublin youtu.be/YrevpY-DNmw
Is Makary's FDA already heading toward a breaking point? ipscell.com/2025/07/is-m... #stemcells #stemcell #CRISPR what does it mean for the cell and gene therapy field?
Is Makary's FDA already heading toward a breaking point? - The Niche
Stem cell biologist writes about how Makary's FDA is already in serious trouble due to politics and a lack of experienced staff.
ipscell.com
How did the pandemic start? I have avoided publicly commenting on this for 5 years. Here's my take as someone who has no stake at all in the game. gidmk.substack.com/p/pandemic-r...
Pandemic Revisionism, Part One: COVID-19 Origins
Because people keep getting this very wrong.
gidmk.substack.com
A well-placed biotech investor says U.S. policies are straining life sciences startups — and more disruption is coming. www.statnews.com/2025/07/15/b...
A well-placed biotech investor says U.S. policies are straining life sciences startups
A well-placed biotech investor says U.S. policies are straining life sciences startups — and more disruption is coming.
statnews.com
