Out Now! Mapping in-cell protein contact sites reveals hijacking of paraspeckles during influenza A virus infection #MicroSky

Mapping in-cell protein contact sites reveals hijacking of paraspeckles during influenza A virus infection

Nature Microbiology, Published online: 20 July 2026; doi:10.1038/s41564-026-02416-1In-cell cross-linking mass spectrometry maps protein contacts in influenza-infected human cells, revealing how the virus hijacks host membrane-trafficking factors and dismantles nuclear paraspeckles to enhance replication.

go.nature.com

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

bioRxivpreprint@biorxivpreprint.bsky.social · 11mo ago

The vault associates with membranes in situ https://www.biorxiv.org/content/10.64898/2025.12.12.693869v1

IsoNet2 determines cellular structures at submolecular resolution without averaging https://www.biorxiv.org/content/10.64898/2025.12.09.693325v1

Excited to share: A Nature Communications study led by Fan Liu (Absea SAB Chair, FMP Berlin) introduces SHVIP—a method revealing 739 virus–host PPIs in intact HSV-1 infected cells. It preserves membrane structure & uses AlphaFold to interpret complex networks. 🔗

Structural host-virus interactome profiling of intact infected cells - Nature Communications

Virus-host protein-protein interactions are fundamental to viral pathogenesis, yet few are structurally resolved. Here, the authors combine cross-linking mass spectrometry, bio-orthogonal labeling…

nature.com

Check out Structural Host–Virus Interactome Profiling (SHVIP) in intact cells infected with Herpes Simplex Virus type 1 (HSV-1)! Now published! 📄 www.nature.com/articles/s41... #LoveVirology #TeamMassSpec

Structural host-virus interactome profiling of intact infected cells - Nature Communications

Virus-host protein-protein interactions are fundamental to viral pathogenesis, yet few are structurally resolved. Here, the authors combine cross-linking mass spectrometry, bio-orthogonal labeling and...

nature.com

Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ... Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus biorxiv.org/content/10.1...