IL-1 family signalling drives mucosal defence against systemic Candida albicans infection

Nature Microbiology, Published online: 05 August 2026; doi:10.1038/s41564-026-02431-2IL-1 family signalling drives host mucosal defence against Candida albicans and, together with neutrophils, prevents mucosal–systemic dissemination and life-threatening fungal disease.

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Salmonella uses sulfate reductases with unique catalytic activity to promote gut colonization in mice

Nature Microbiology, Published online: 05 August 2026; doi:10.1038/s41564-026-02443-yExtracytoplasmic MopB-family sulfate reductases using Fe–S clusters instead of molybdenum as a cofactor enable sulfate assimilation in Salmonella to support gut colonization and virulence, and help to counter host-imposed oxidative stress.

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Genomic surveillance reveals co-occurrence of Plasmodium falciparum drug resistance variants across diverse transmission settings in Ethiopia

Nature Microbiology, Published online: 05 August 2026; doi:10.1038/s41564-026-02420-5Artemisinin partial resistance is expanding in Ethiopia and, together with a dominant lumefantrine-tolerant PfMDR1 haplotype and co-occurring Pfcrt and Pfk13 mutations, defines a complex multidrug-resistance landscape that may reflect overlapping treatment pressures in Plasmodium vivax and Plasmodium falciparum co-endemic settings.

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A review of Bundibugyo virus and the 2026 outbreak: lessons for epidemic preparedness

The ongoing 2026 outbreak of Ebola virus disease caused by Bundibugyo virus (BDBV) in the Democratic Republic of the Congo and Uganda has renewed attention to one of the least studied human-pathogenic...

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Focusing on full submissions

Nature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02452-xNature Microbiology no longer considers presubmission enquiries and instead evaluates all research through full manuscript submissions. This change is intended to improve fairness, rigour and efficiency, ensuring that editorial decisions are based on a complete assessment of the data.

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A microbial PPARadigm for gut protection

Nature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02423-2Two independent studies converge on the nuclear receptor PPARα as a key node in gut microbiome communication, highlighting it as a potential therapeutic target in intestinal diseases.

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Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy

Nature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02433-0Lactiplantibacillus plantarum-derived fatty-acid metabolite, 10-hydroxystearic acid, interacts directly with PPARα to alter histone crotonylation and the transcriptional landscape which leads to gut barrier functional repair and enhanced viral suppression in non-human primate models when combined with anti-retroviral therapy.

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Combined phage therapy and faecal microbiota transplantation to treat recurrent urinary tract infection: a case series

Nature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02409-0In a small case series, combined phage therapy and faecal microbiota transplantation was safe and led to sustained reductions in recurrence, severity and antibiotic use in women with recurrent urinary tract infections, even without complete eradication of Escherichia coli.

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Cell-autonomous immunity as an integrated immune network against bacterial and viral pathogens

Nature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02428-xThis Review summarizes the current knowledge about the cell-intrinsic factors that act against pathogenic bacteria and viruses and the immune evasion strategies that pathogens have to counteract cell-autonomous immunity.

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Phage hijacks host phosphorothioate DNA modification machinery to circumvent bacterial Ssp defences

Nature Microbiology, Published online: 29 July 2026; doi:10.1038/s41564-026-02387-3The phage-encoded protein PptA enables its DNA to masquerade as the host and evade cleavage, providing a potential foundation for engineering therapeutic phages that could bypass this widespread defence system.

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Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice

Nature Microbiology, Published online: 29 July 2026; doi:10.1038/s41564-026-02434-zLipidomics and proteomics in mice colonized with variable gut microbiota reveal an important role of gut microbes in restricting lipid uptake via triggering Myd88 signalling and the degradation of phosphatidylcholine in bile.

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Unique adaptations in sulfatases underpin colonic mucin degradation by Akkermansia muciniphila - Nature Microbiology

Structural and biochemical follow-up of a serendipitous discovery reveals that Akkermansia muciniphila carbohydrate sulfatases are uniquely adapted to digest colonic mucins in collaboration with other...

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Unique adaptations in sulfatases underpin colonic mucin degradation by Akkermansia muciniphila

Nature Microbiology, Published online: 27 July 2026; doi:10.1038/s41564-026-02424-1Structural and biochemical follow-up of a serendipitous discovery reveals that Akkermansia muciniphila carbohydrate sulfatases are uniquely adapted to digest colonic mucins in collaboration with other members of gut microbiota.

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Antiviral GHP-88310 blocks contact-mediated and airborne transmission in a ferret model of measles-like disease

Nature Microbiology, Published online: 24 July 2026; doi:10.1038/s41564-026-02419-yAntiviral candidate GHP-88310 provides therapeutic benefit against measles-like disease and protects against productive direct-contact and airborne viral transmission when used for pre- and post-exposure prophylaxis.

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Ebola virus persistence and the hidden cost of immune privilege

Nature Microbiology, Published online: 23 July 2026; doi:10.1038/s41564-026-02432-1Human brain organoids reveal how Ebola virus establishes persistent infection within the immune-privileged environment of the central nervous system.

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Within-patient gene transfer between transiently and chronically infecting bacteria causes extreme antibiotic resistance during lung infections

Nature Microbiology, Published online: 23 July 2026; doi:10.1038/s41564-026-02414-3Antibiotic resistance gene acquisition by Pseudomonas aeruginosa and Achromobacter from transiently infecting bacteria drives rapid and extreme resistance to tobramycin during chronic lung infection within patients.

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Clarifying objectives to strengthen wastewater-based AMR surveillance

Nature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02429-wClarifying objectives to strengthen wastewater-based AMR surveillance

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Molecular and cellular insights into the parasitic infection of bloom-forming marine diatoms by Pirsonia diadema

Nature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02421-4Ultrastructure expansion microscopy, live-cell imaging and time-resolved dual RNA sequencing reveal the infection dynamics of a microparasite, providing insights into how Pirsonia diadema shapes marine trophic networks.

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Groundwater microbial communities across the terrestrial subsurface

Nature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02427-yHere the authors propose the concept of ‘microbial frugality’ as an evolutionary outcome of life under the chronic energy limitation of the subsurface and a way to understand Earth’s hidden biogeochemical engine.

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Klebsiella pneumoniae inhibits vasodilation through capsule and T6SS-dependent pathways

Nature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02425-0Vasodilation is inhibited by Klebsiella pneumonia through a multipronged approach involving type VI secretion system activity and the VgrG4 effector, plus capsule, to limit eNOS-dependent and endothelial hyperpolarization routes to vasodilation.

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Mapping in-cell protein contact sites reveals hijacking of paraspeckles during influenza A virus infection

Nature Microbiology, Published online: 20 July 2026; doi:10.1038/s41564-026-02416-1In-cell cross-linking mass spectrometry maps protein contacts in influenza-infected human cells, revealing how the virus hijacks host membrane-trafficking factors and dismantles nuclear paraspeckles to enhance replication.

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All-trans retinoic acid suppresses systemic inflammation induced by severe fever with thrombocytopenia syndrome virus in mice

Nature Microbiology, Published online: 20 July 2026; doi:10.1038/s41564-026-02411-6Depletion of the vitamin A metabolite all-trans retinoic acid (ATRA) in patients infected with severe fever with thrombocytopenia syndrome virus correlates with severe inflammation. In mice, ATRA supplementation reduces IL-6 levels and hyperinflammation.

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Predictable shifts in microbial species composition lead to community-wide robustness to environmental stress

Nature Microbiology, Published online: 17 July 2026; doi:10.1038/s41564-026-02422-3Environmental stress shifts microbial composition towards species with high growth rates, providing community-wide protection.

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Bacillus subtilis cells can escape biofilms by producing a hydrogel that ejects them

Nature Microbiology, Published online: 16 July 2026; doi:10.1038/s41564-026-02430-3Bacillus subtilis biofilms can disperse by ejecting motile cells using osmotic pressure generated by a secreted hydrogel. This mechanism of biofilm dispersal has mechanistic parallels to a process in evolutionarily distant Cnidaria and might inform new therapeutic approaches to control biofilm dispersion.

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Mobile genetic elements shape microbial diversity and functions in thawing permafrost soils - Nature Microbiology

An 8-year soil meta-omic time series shows how mobile genetic elements shape permafrost microbial diversity and impact a range of functions, including carbon and nutrient cycling.

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New nucleases target modified DNA

Nature Microbiology, Published online: 13 July 2026; doi:10.1038/s41564-026-02418-zBacteriophages often use hypermodified DNA to protect themselves from host defences. The END nucleases found in bacteria represent a new class of modification-dependent endonucleases recognizing diverse DNA modifications, allowing a single system to protect the cell against multiple phage types.

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