🧵 New protocol out in @cp-starprotocols.bsky.social! Step-by-step guide to infer forces in tissues using ForSys, by @borgesaugust.bsky.social, Jeronimo Miranda, Alberto Ceccarelli, Guilherme Ventura, @kuba-sedzinski.bsky.social, @hernanlopez-schier.bsky.social and I, www.cell.com/star-protoco...

🚨 #postdoc to be hired in the Paluch Lab 🚨 If you know anyone experienced with and, more importantly, excited about nanoscale architecture of #actincortex and super-res & electron #microscopy do encourage them to apply👇 Amazing colleagues, can only recommend 😉 www.cam.ac.uk/jobs/researc...

Happy to share this work from Carlos Camacho de la Maccora that reveals how rates of posterior progenitor addition and anterior vacuolation are balanced across the notochord. With Alberto Ceccarelli and @osvaldo-chara.bsky.social we present a model of long-range communication to provide robustness.

🚨 New Preprint from the Paluch & Chalut Labs 🚨 Ana Raffaelli et al show that the stiffness of substrate (in vitro) / basal membrane (in vivo) determine how cells interpret biochemical signals (BMP4) and which fates they acquire #mechanobiology #hESCs #substratemechanics doi.org/10.64898/202...

Curious about how to achieve organ-wide #regeneration through locally controlled cell proliferation? Check out our latest computational adventure addressing this problem in the #neuromast within the #zebrafish lateral line. doi.org/10.1016/j.jt... (1/9)

Thrilled to have contributed to this @nature.com study on ethylene and cell wall mechanics in root compaction responses!! — Featuring Jiao Zhang, Lucas Peralta Ogorek, @borgesaugust.bsky.social , Bipin Pandey, Staffan Persson, Wanqi Zhang, Malcolm Bennett & more!! www.nature.com/articles/s41...

Ethylene modulates cell wall mechanics for root responses to compaction - Nature

Soil compaction traps ethylene around roots, which causes transcriptional upregulation of Auxin Response Factor1, resulting in decreased root cortical cell wall thickness and thereby promoting root ra...

nature.com

Mechanical forces can affect the way tissue grows. Ideally, we want to characterize them without interfering with the processes we are studying. Is there a way to achieve this? I am @borgesaugust.bsky.social Welcome to my stress inference tutorial! #EpithelialMechanics

Borges, A., Miranda-Rodriguez, J. R., Ceccarelli, A., Ventura, G., Sedzinski, J., Lopez-Schier, H., & Chara, O. (2025). ForSys: non-invasive stress inference from time-lapse microscopy. iScience, 28, 113685. #EpithelialMechanics buff.ly/jQ96TCK

Our ForSys method to infer the mechanical state of a tissue in space and time is published now in @cp-iscience.bsky.social ! www.cell.com/iscience/ful... (1/10)

Borges, A., & Chara, O. (2024). Peeking into the future: inferring mechanics in dynamical tissues. Biochemical Society transactions, 52(6), 2579–2592. #EpithelialMechanicsReview buff.ly/sntsjqb

Can we use morphology and dynamics to understand the mechanical state of tissues better? Here is a brief thread about our recent mini-review with @osvaldo-chara.bsky.social !

Osvaldo Chara@osvaldo-chara.bsky.social · 2y ago

Excited to share this mini-review on dynamic mechanical stress inference of tissues written with @borgesaugust.bsky.social!! doi.org/10.1042/BST2... (1/8)