Very interesting work by Dorothy Kern and @hkws.bsky.social. They look at what's missing in NMR assignments, and use it to train a deep learning model for predicting protein dynamics. Clever approach! www.nature.com/articles/s41...
nature.com
Borja Mateos
@borjaml.bsky.social
Assistant Professor at @ub.edu | I like to play with nuclear spins in the triple point (chemistry, biology and physics).
Job opening - NMR Facility Scientist (Senior Technical Staff, PTA · Tècnic Superior), High-Field NMR Facility, CCiTUB Barcelona @borjaml.bsky.social bsky.app/profile/ccit... #NMRjobs #NMRchat #NMR 🧲 Working proficiency in English; Catalan and/or Spanish desirable
Centres Científics i Tecnològics (CCiTUB)@ccit.ub.edu · 3mo ago#ICTSNews | 📢 La Unitat de #Ressonància i #Magnetisme dels #CCiTUB busca incorporar un nou membre a les instal·lacions del Campus Diagonal. 📩 Envia carta de presentació, CV i (si és possible) carta de referència a: • francardenas@ub.edu • mgairi@ub.edu • tgonzalez@ub.edu 📆 Fins al 𝟭𝟬 𝗱’𝗼𝗰𝘁𝘂𝗯𝗿𝗲!
Helium supplies are tight—and it could get worse Scientific users report surcharges and regional shortages due to the war in Iran. cen.acs.org/business/spe... #chemsky 🧪
The helium shortage is now unavoidable. Another wonderful follow-on to the Iran War, and if you think helium doesn’t matter much, think again:
Helium and the Strait of Hormuz
science.org
Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !
Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule
The druggability of intrinsically disordered regions.
science.org
We are open for novel NMR projects and users! Our biomolecular NMR expertise: ✅ Drug discovery (fragments & biologics) ✅ Intrinsically Disordered Proteins (IDPs) Let’s get to work! 👉 tuit.cat/i9V81 #ICTSNews #IntegrativeStructuralBiology #NMR #NMRChat
🆕 The #CCiTUB participate at the Instruct-ES Workshop celebrating the expansion of @instruct-eric.bsky.social! 🔬 Dr. @borjaml.bsky.social @ub.edu introduced our high-field NMR services. Helping to build a community combining talent & tech to tackle modern biology big questions 🧬✨ 🔗 tuit.cat/a3FGV
🆕 Els #CCiTUB @ub.edu han acollit la primera trobada de responsables de Serveis Cientificotècnics (SCT) d' #universitats catalanes amb l'objectiu de crear un espai estable de coordinació a escala catalana i enfortir els serveis de suport a la #recerca. 🔗 tuit.cat/85S6t
Looking forward to host Luca!!! Join us to learn about the perfect tandem of NMR and glycobiology
IRB Barcelona@irbbarcelona.org · 9mo agoJoin us in our extraordinary Research Nodes #seminar next week, organised jointly with @ibecbarcelona.eu, with Dr, Luca Unione, from @cicbiogune.bsky.social. Hosted by Dr. @borjaml.bsky.social (#IRBBarcelona) & Dr. Irene Marco-Rius (#IBEC) Register here ➡️ https://shorturl.at/vMXM0 🧪
Calling researchers in Spain! Don't miss out on the Instruct-ES Workshop, the first meeting of the expanded Spanish Centre in Instruct-ERIC Find out all about the technologies and latest research taking place at Instruct Centre Spain - register here 👇 instruct-eric.org/events/integ...
Senior Scientist to join the NMR Centre and the Institute of Organic Chemistry, University of Vienna, Austria, extensive hands-on experience with NMR, EPR, DNP spectrometers, will oversee the operations of the advanced NMR core facility www.nature.com/naturecareer... #NMRjobs #NMRchat 🧲
Senior Scientist - Wien, Österreich job with University of Vienna | 12849256
At the University of Vienna almost 11,000 personalities work together towards answering the big questions of the future. Around 7,700 of them do re...
nature.com
Happy to contribute to this work!
Paul Robustelli@paulrobustelli.bsky.social · 10mo agoProud to share our manuscript: "How small molecules stabilize oligomers of a phase-separating disordered protein" www.biorxiv.org/content/10.1... by Jiaqi Zhu and Tommy Sisk, in collaboration with @borjaml.bsky.social , Stase Bielskute-Garcia & @xsalvatella1.bsky.social
Per Joan Massagué, els bons mentors han de reunir diverses qualitats, que es poden resumir en l’acrònim ICECRAM #InauguracióUPF
✨ Couldn’t agree more with Jane Clark’s words on life and science culture! And now… "back to kinetics and mechanisms again!" Tales of teaching and teamwork | Nature Reviews Chemistry share.google/gtk7OPl6Rmbs...
Tales of teaching and teamwork - Nature Reviews Chemistry
Ahead of her 75th birthday, Jane Clarke discussed her life in science, including her career change from school science teacher to protein folding researcher.
share.google
I’m carrying out a short survey of NMR TITAN users - if you’ve made use of this tool in your research, or have suggestions for its future development, I’d be grateful for your input: forms.gle/MMXYwSozszhi... #nmrchat
NMR TITAN user survey
This survey aims to assess the impact of NMR TITAN on biomolecular research and identify priorities for future development. The form should take approximately 5 minutes to complete. Your responses may...
forms.gle
Happy to share that Javier has been awarded the 2025 RSEQ “Young Researchers” Prize (Postdoctoral category). We are grateful to the Governing Board for this recognition, which supports our work in organic synthesis and catalysis at @univie.ac.at rseq.org/concesion-de...
Concesión de los Premios RSEQ 2025 – RSEQ
Concedidos los Premios de la Real Sociedad Española de Química en su edición 2025.
rseq.org
🚨 PhD Opportunity Alert! Repost appreciated!🔁 A fully funded PhD position is available in the Mateos Group at the University of Vienna! 🔹 Up to 4y of funding 🔹 Application deadline: April 21, 2025 👉 More info: doschem.univie.ac.at/application/... #PhDPosition #Chemistry #Catalysis (1/4)
Open Positions 2025
Open Positions 2025
doschem.univie.ac.at
The Specialised Group of NMR of the Spanish Royal Society of Chemistry (GERMN-RSEQ) is pleased to announce the XVI International Manuel Rico NMR School. #NMRchat 🗓️1st to 6th June 2025 ⛰️Jaca (Spain) germn.rseq.org/actividades1...
International Manuel Rico NMR School – GERMN
Throughout its editions, this wellestablished course organized by the specialized Nuclear Magnetic Resonance (NMR) group of the RSEQ (GERMN) has become an excellent platform for improving the underst...
germn.rseq.org
Rocket science alert 🚀! Check out our latest preprint describing the new sample shuttle developed by @brukercorporation.bsky.social with our friends at @cerm-cirmmp.bsky.social and us. With support from @ec.europa.eu and @agencerecherche.bsky.social #NMRChat #chemsky
A fast sample shuttle to couple high and low magnetic fields. Applications to high-resolution relaxometry
Abstract. Combining high-field high-resolution NMR with an evolution of spin systems at low magnetic field offers many opportunities for the investigation of molecular motions, hyperpolarization and t...
mr.copernicus.org
How do proteins mis-fold? Paper led by Jacob Aunstrup from Alex Büll’s lab with MD simulations by Abigail Barclay, and key contributions from several others. We combined measurements of Φ-values with MD simulations to study the transition state for amyloid fibril growth doi.org/10.1038/s415...
📢 New preprint! 📄 Deciphering the molecular forces behind the exceptional binding affinity of the streptavidin-biotin complex via NMR and QM. 🔍 Check it out: www.biorxiv.org/content/10.1... #StructuralBiology #NMR #ComputationalChemistry #DrugDiscovery
From Weak Interactions to Strong Affinity: Deciphering the Streptavidin-Biotin Interaction through NMR and Computational Analysis
Understanding weak interactions in protein-ligand complexes is essential for advancing drug design. Here, we combine experimental and quantum mechanical approaches to study the streptavidin-biotin com...
biorxiv.org
This review focuses on the importance of disordered water molecules in protein structures and discusses currently established methods of measuring the hydration states of proteins, their applications, and limitations. ow.ly/wknc50UtrIN
Hidden water’s influence on rhodopsin activation
Structural biology relies on several powerful techniques, but these tend to be limited in their ability to characterize protein fluctuations and mobility. Overreliance on structural approaches can lead to omission of critical information regarding biological function. Currently there is a need for complementary biophysical methods to visualize these mobile aspects of protein function. Here, we review hydrostatic and osmotic pressure-based techniques to address this shortcoming for the paradigm of rhodopsin.
ow.ly
Universidades: Madrid y Catalunya www.lavanguardia.com/opinion/2024... Mas-Colell sobre el “trilema” de la universidad: demanda futura, restringir expansión privada, costes crecientes. Su solución: Permitir a la universidad pública crear entes de derecho privado bajo su control. Muy interesante.
Universidades: Madrid y Catalunya, por Andreu Mas-Colell
La Comunidad de Madrid, poco amiga de las universidades públicas, está desplegando una política favorable a la creación y expansión de universidades privadas. En
lavanguardia.com
1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field
Full room today to see Albert' (from @benlehner.bsky.social lab at @crg.eu ) work! Really insightful datasets!
Our work on how CPEB4 mis-splicing leads to its aggregation in autism spectrum disorder is now published in Nature. rdcu.be/d2qjW I would like to thank the collaborators who joined the team during the revision process as well as the funders who supported us.
Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD
Nature - The molecular mechanisms of how small changes in the degree of inclusion of a neuron-specific microexon in CPEB4 lead to dominant-negative effects in the expression of genes associated...
rdcu.be
IRB Barcelona@irbbarcelona.org · 2y ago🫧🔍Key breakthrough in #autism: pivotal role of #CPEB4 condensates revealed. 💊The study opens new avenues for the development of targeted treatments for autism. 📰 Nature @natureportfolio.bsky.social ✍️ Carla Garcia-Cabau, Anna Bartomeu et al. ➡️ bit.ly/3BfEGlR 📌 DOI: 10.1038/s41586-024-08289-w
🫧🔍Key breakthrough in #autism: pivotal role of #CPEB4 condensates revealed. 💊The study opens new avenues for the development of targeted treatments for autism. 📰 Nature @natureportfolio.bsky.social ✍️ Carla Garcia-Cabau, Anna Bartomeu et al. ➡️ bit.ly/3BfEGlR 📌 DOI: 10.1038/s41586-024-08289-w
It's a little bit late, but I'm really excited for my first paper! For reaction monitoring by NMR, signal-averaging can be applied *after acquisition*, and results in better S/N *and* data density without the typical trade-off. pubs.acs.org/doi/10.1021/... #NMRchat #NMR @lloydjonesgroup.bsky.social
Simple Parameters and Data Processing for Better Signal-to-Noise and Temporal Resolution in In Situ 1D NMR Reaction Monitoring
In situ 1D NMR spectroscopic reaction monitoring allows detailed investigation of chemical kinetics and mechanism. Concentration versus time data are derived from a time series of NMR spectra. Each sp...
pubs.acs.org