xavier salvatella
@xsalvatella1.bsky.social
Scientist at ICREA and IRB Barcelona.
Allostery is a widespread cause of loss-of-function variant pathogenicity by @xt117.bsky.social @sangerinstitute.bsky.social www.nature.com/articles/s41...
Allostery is a widespread cause of loss-of-function variant pathogenicity - Nature Communications
Mutations at sites distant from a protein’s active site can disrupt function through allosteric mechanisms. Here, authors present evidence that allostery is a widespread and underappreciated cause of ...
nature.com
I am so glad to share that our paper is finally out!!!
Basil Greber@bjgreber.bsky.social · 3w agoHappy that our most recent paper on nucleotide excision repair mechanisms has now been published in Science Advances. This project was led by @natalia-mg.bsky.social and @callumhaste.bsky.social and focused on visualising early steps of the NER process by #cryoEM. www.science.org/doi/10.1126/...
Discovery of Potential First-in-Class Dual Ligand-Directed Degrader and Antagonist of the Androgen Receptor: BMS-986365 | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
Discovery of Potential First-in-Class Dual Ligand-Directed Degrader and Antagonist of the Androgen Receptor: BMS-986365
Androgen receptor (AR) signaling is central to the progression of prostate cancer, including castration-resistant disease. Targeted protein degradation, particularly through heterobifunctional compoun...
pubs.acs.org
Desorden intrínseco en proteínas, multivalencia y multimerización RevistaSEBBM 229junio2026 por @xsalvatella1.bsky.social No todas las proteínas funcionan desde una estructura fija. @irbbarcelona.org https://f.mtr.cool/mvwgjybijj
Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.
cell.com
Design and structure of protein cages based on helical fusion and machine learning www.biorxiv.org/content/10.64898/2026.05.27.727936v1 #cryoEM
Memorial Minute for Martin Karplus - Harvard Gazette news.harvard.edu/gazette/stor... #NMRchat 🧲
Memorial Minute for Martin Karplus — Harvard Gazette
At a meeting of the Faculty of Arts and Sciences on May 5, 2026, the following tribute to the life and service of the late Martin Karplus was spread upon the permanent records of the Faculty.
news.harvard.edu
Interested in molecular motors? Don’t miss this wonderful symposium in Salamanca on "The Structure and Workings of Molecular Machines" with an outstanding lineup of speakers. 📍 Salamanca, Spain 📅 Monday, June 22, 2026 🎟️ Attendance is free, but registration is required 👇👇👇
4th Workshop on Structural Biophysics, October 12-16, 2026, Bordeaux, France, registration closes May 19 www.cbmn.u-bordeaux.fr/ivth-worksho... #NMRchat 🧲
IVth Workshop on Structural Biophysics. - CBMN
5 jours de Workshop en Biophysique à Bordeaux ! Les techniques en biophysique permettent d’appréhender les mécanismes d’interactions entre entités biomoléculaires à une échelle allant de la taille de ...
cbmn.u-bordeaux.fr
Check out the phenomenal PhD work by Katie Copley, a current postdoc in our lab @yaleneuro.bsky.social @yalerna.bsky.social. www.science.org/doi/10.1126/...
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how sho...
science.org
Join Stanford Chem for this year's McConnell Lecturer in Chem: Prof. Lewis E. Kay (Univ. of Toronto), a pioneer in biomolecular NMR. He’ll present “The Essentiality of Solution NMR Spectroscopy in the Post-Alpha Fold Era,” May 5, 3–4 PM, Sapp Center 114. chemistry.stanford.edu/events/mccon...
🧬 Mutations in the "translators" of the human cell alter the reading of the genetic code in #cancer and #aging. ✍️ Lluís Ribas (#IRBBarcelona) et al. 📰 @genomeresearch.bsky.social Read more ➡️ https://shorturl.at/5pk2P 📌 DOI: 10.1101/gr.281022.125 #IRBScience #AgeingResearch #AgingResearch 🧪
Does AlphaFold’s latent space encode only the native state or something like a distribution over conformations? We begin to answer this question with ConforNets, a mechanism for producing diverse states, or very specific ones, via inference-time adaption of OF3p’s latent space👇
Minji Lee@m1nj2.bsky.social · 4mo agoWe introduce ConforNets, a mechanism for conformational control in AlphaFold3 models - SoTA at producing diverse conformations on every multistate benchmark (N=104) - Novel capability: transfer state from one protein to another Outperforms BioEmu, ConforMix and AFsample3 🧵1/8
El nou edifici que acolllirà grups de recerca de 5 centres #BISTCommunity i enfocat en medicina de precisió va prenent forma. 👉https://www.ara.cat/societat/horitzo-2028-gran-hub-biomedicina-sud-d-europa-pren-forma_1_5702563.html?giveAway=uCQdvPiwpW4GkqLE
🔬A new mechanism explains how protein production is regulated in #FattyLiver under metabolic stress. 📰 Science Advances ✍️ Raúl Méndez, Eulàlia Belloc, Vittorio Calderone, Mercedes Fernández, @idibaps.bsky.social @ptck72.bsky.social et al. ➡️ https://shorturl.at/UtRVB 📌 DOI: 10.1126/sciadv.aea4125
Our linker histone H1 paper is featured on the cover of the April 10 issue of #ScienceAdvances. www.science.org/doi/10.1126/... A molecular dynamics simulation of nucleosomes and linker histone H1, with single-H1 trajectories (background). 🎉 Full cover caption: www.science.org/toc/sciadv/1...
Kazuhiro Maeshima@kazu-maeshima.bsky.social · 4mo agoOur H1 paper is out #ScienceAdvances: www.science.org/doi/10.1126/... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social tinyurl.com/REWIRE-PD
📢 We are #hiring! #GroupLeader positions open at #IRBBarcelona in #ChemicalBiology and #StructuralBiology. Application deadline: May 22, 2026 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗖𝗵𝗲𝗺𝗶𝗰𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ shorturl.at/1tE3n 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ shorturl.at/eKiJn #IRBJobs #Jobs #AcademicSky
#paper #highlight February 2026 Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule By S. Bielskutė-García et al in #ScienceAdvances sbe.es/highlights-p... @xsalvatella1.bsky.social @irbbarcelona.org @icreacommunity.bsky.social
📢 Upcoming Seminar | Join us for a plenary seminar this Friday, with Dr. @adelaljord.bsky.social, from the @crg.eu. 🤝 Hosted by Dr. @xsalvatella1.bsky.social Register here ➡️ https://shorturl.at/A9VMZ #IRBBarcelona #Seminar
Happy to announce that my institution, @irbbarcelona.org, is opening two group leader positions, 1 in chemical biology and 1 in structural biology, to strengthen our expertise in molecular sciences: please spread the word !
IRB Barcelona@irbbarcelona.org · 5mo agoWe are #hiring! #GroupLeader positions open at #IRBBarcelona in #ChemicalBiology and #StructuralBiology. Application deadline: May 22, 2026 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗖𝗵𝗲𝗺𝗶𝗰𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ https://shorturl.at/1tE3n 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ https://shorturl.at/eKiJn #IRBJobs #Jobs #AcademicSky
Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !
Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule
The druggability of intrinsically disordered regions.
science.org
IDPSeminars is back TOMORROW! Come see @tanjamittag.bsky.social and @xsalvatella1.bsky.social ! Not to be missed!!
Yeast ubiquilin Dsk2 scaffolds proteasome-containing condensates under stress via multivalent interactions – @castanedalab.bsky.social et al show how dynamic interactions among its STI1 domain & transient helices in its disordered region promote its phase-separation link.springer.com/article/10.1...
STI1 domain engages transient helices to mediate Dsk2 phase separation and proteasome condensation - The EMBO Journal
Ubiquitin-binding shuttle proteins are important components of stress-induced biomolecular condensates in cells. Yeast Dsk2 scaffolds proteasome-containing condensates via multivalent interactions wit...
link.springer.com
In 2017 we showed that homomers evolve on the edge of supramolecular self-assembly. Here we show how to exploit this vulnerability so that ALL homomers can become bona fide drug-🎯. Delighted that Aim 3 of our @erc.europa.eu finally polymerized! Manuscript: 👉 rdcu.be/e27bT
Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve
📢 #MAINFRAME Symposium comes to Barcelona! Experts in #AI, computational chemistry & small-molecule #DrugDiscovery meet to advance open, large-scale screening for 2,000+ human proteins. 📆 Mar 18–19 📍 Ateneu Barcelonès ℹ️ https://shorturl.at/1aKKS @ptck72.bsky.social
🚨WE'RE RECRUITING AT @irbbarcelona.org !!!! --- ADVANCED GENOMICS FACILITY MANAGER --- An amazing opportunity to help us drive the fight against cancer and other aging-related diseases using Single-cell, Bulk and Spatial genomics!!!! APPLY NOW!!!! recruitment.irbbarcelona.org/jobs/7124180...
Head, Advanced Genomics Technologies Core Facility (Ref. CF/26/01) - IRB Barcelona
IRB Barcelona invites applications for the position of Head, Advanced Genomics Technologies Core Facility. The successful candidate will report to the Director, Technology Strateg...
recruitment.irbbarcelona.org