@brandon-beaber.bsky.social
A summary of studies showing how genes could affect the efficacy of different medications in multiple sclerosis: link.springer.com/article/10.1...
Genetic Risk in Multiple Sclerosis: Susceptibility, Modifiers and Unresolved Questions - Neurology and Therapy
Multiple sclerosis (MS) is a chronic, immune-mediated disorder of the central nervous system (CNS) characterised by inflammation, demyelination and neurodegeneration. The aetiology of MS is complex, a...
link.springer.com
Can you just stop b-cell depleting drugs for MS? This observational study on people over 50 (not a randomized trial) showed people who continued treatment had similar outcomes to those who stopped treatment, though median follow up was only 2.9 years. pubmed.ncbi.nlm.nih.gov/42596034/
The shingles vaccine is about 64-81% effective in people with multiple sclerosis (retrospective analysis of medicare data). pubmed.ncbi.nlm.nih.gov/42590996/
Effectiveness of the recombinant zoster vaccine in adult patients with multiple sclerosis: A claims-based retrospective cohort study in the United States - PubMed
RZV demonstrated robust VE, preventing 64%-81% of HZ cases in this MS population predominantly aged 50 years or older.
pubmed.ncbi.nlm.nih.gov
Lyrica (pregabalin) Explained by Neurologist youtu.be/vQT0tf4MTuY?...
Lyrica (pregabalin) Explained by Neurologist
YouTube video by Dr. Brandon Beaber
youtu.be
Dr. Glaucomflecken Explains: Rituximab versus Ocrelizumab and the recent randomized trial youtube.com/shorts/cXPAk...
Dr. Glaucomflecken Explains: Rituximab versus Ocrelizumab in Relapsing Multiple Sclerosis
YouTube video by NEJM Group
youtube.com
Christina Applegate's Multiple Sclerosis Symptoms youtube.com/shorts/x6I8d...
Christina Applegate's Multiple Sclerosis Symptoms
YouTube video by Dr. Brandon Beaber
youtube.com
The prevalence of multiple sclerosis in Qatar is about 1 in 845. Historically it was thought to be very rare. pubmed.ncbi.nlm.nih.gov/42542074/
Incidence and prevalence of multiple sclerosis in Qatar: A population-based study from 2016 to 2024 - PubMed
Incidence among Qatari nationals is comparable to rates reported from Kuwait, the United Arab Emirates, and Iran, and approaches those of high-incidence regions. The minimum prevalence represents a su...
pubmed.ncbi.nlm.nih.gov
A New Remyelinating Drug For MS: CN045 youtu.be/62vskysF4jE?...
A New Remyelinating Drug For MS: CN045
YouTube video by Dr. Brandon Beaber
youtu.be
Ocrevus in black and hispanic people. The CHIMES single arm unrandomized trial found ocrevus had similar efficacy and side effects compared to what would be expected from the randomized (OPERA I/II) trials. onlinelibrary.wiley.com/doi/10.1002/...
Two Years of Ocrelizumab Treatment in Black and Hispanic People with Multiple Sclerosis in <fc>CHIMES</fc>: A Single‐Arm Clinical Trial
Objective To evaluate the effectiveness and safety of ocrelizumab in self-identified black and Hispanic people with relapsing multiple sclerosis. Methods The Characterization of Ocrelizumab in Mino.....
onlinelibrary.wiley.com
34.8% of people receiving briumvi for multiple sclerosis have an infusion reaction. These are some of the regimens attempted to prevent reactions. pubmed.ncbi.nlm.nih.gov/42534927/
LUCID-MS, a Myelin Stabilizer for Multiple Sclerosis youtube.com/shorts/yIGZT...
LUCID-MS, a Myelin Stabilizer for Multiple Sclerosis
YouTube video by Dr. Brandon Beaber
youtube.com
Prevalence of Lyme antibodies in people with multiple sclerosis is very low. Author is a young Dr. Patricia Coyle (1989)! www.neurology.org/doi/pdf/10.1...
Drs. Sammita Satyanarayan and Fred Lublin argue we should get rid of multiple sclerosis phenotypes like "relapsing remitting MS" and "secondary progressive MS" in favor of a continuous disease spectrum model journals.sagepub.com/doi/10.1177/...
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
Do you need annual screening MRI scans if you have multiple sclerosis and you take ocrevus? In this analysis of 342 people on ocrevus and 1,639 follow-up MRI scans, only 1.8% of scans had new findings which "never led to treatments changes" pubmed.ncbi.nlm.nih.gov/42525900/
CN045, a new remyelinating treatment for MS? Researchers screened 20,000 small molecules in rodent models of demyelination for stimulation of oligodendrocyte progenitor cells (OPCs). Myelin basic protein (magenta) surrounding an axon in the image pmc.ncbi.nlm.nih.gov/articles/PMC...
A novel small molecule remyelination therapy for multiple sclerosis
We conducted a phenotypic screen of 20,000 central nervous system (CNS)-biased small molecules for their ability to stimulate differentiation of mouse oligodendrocyte progenitor cells (OPCs) into olig...
pmc.ncbi.nlm.nih.gov
Can people with multiple sclerosis develop new asymptomatic spinal cord lesions? Yes. This metanalysis of 1637 people found the risk was 13%. pubmed.ncbi.nlm.nih.gov/42497800/
Asymptomatic spinal cord lesions in Multiple Sclerosis: A systematic review and meta-analysis of subclinical disease activity - PubMed
Available evidence suggests that new asymptomatic spinal cord lesions may occur during clinically stable follow-up in a meaningful proportion of pwMS. Clinicians should recognize that spinal cord acti...
pubmed.ncbi.nlm.nih.gov
If you live long enough, is dementia inevitable? MAYBE NOT! This study on 124 people >/= 90 years old (mean age 96) found only 35% had dementia. 41% had normal cognition, and 23% had some mild cognitive impairment. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com
Upcoming videos: 7/29: smoking and MS 8/5: Lyrica (pregabalin) 8/12: bell’s palsy 8/19: MS: probability of needing a wheelchair www.youtube.com/@DrBrandonBe...
Dr. Brandon Beaber
I am a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system, and I post new videos about MS every Wednesday Check out my...
youtube.com
Risk of requiring a wheelchair (EDSS >/= 7.0) with secondary progressive multiple sclerosis over 3 years from the EXPAND trial. 5.9% with Mayzent (Siponimod) vs. 8.1% with placebo. Risk very low for baseline EDSS <6.5. onlinelibrary.wiley.com/doi/full/10....
Risk of requiring a wheelchair (EDSS >/= 7) in primary progressive MS with ocrevus vs. no treatment (comparison of OROTORIO trial participants vs. HISTORICAL control of MSBase registry subset with similar baseline characteristics (EDSS 3-6.5). ddd.uab.cat/pub/artpub/2...
Christina Applegate's Breast Cancer journey and BRCA mutation; From Christina Applegate's Autobiography "You with the Sad Eyes" www.youtube.com/shorts/sQo7c...
Christina Applegate's Breast Cancer Journey and BRCA1 Mutation
YouTube video by Dr. Brandon Beaber
youtube.com
Does epidural anaesthesia for pain relief during childbirth increase the risk of multiple sclerosis relapses? ABSOLUTELY NOT! This study found no difference with (red) and without (blue) an epidural. pmc.ncbi.nlm.nih.gov/articles/PMC...
Proportion of people with relapsing who DID NOT transition to secondary progressive multiple sclerosis vs. years since diagnosis. pmc.ncbi.nlm.nih.gov/articles/PMC...
Multiple sclerosis is becoming milder on the average. Risk of reaching EDSS 4.0 (moderate disability) vs. period of onset journals.sagepub.com/doi/10.1177/...
Those with secondary progressive multiple sclerosis consistently using disease modifying therapy had a lower risk of requiring a wheelchair (EDSS >/=7). Observational data from MSBase registry: 4997 people www.researchgate.net/publication/...
(PDF) Association of Sustained Immunotherapy With Disability Outcomes in Patients With Active Secondary Progressive Multiple Sclerosis
PDF | Importance It is unclear whether relapses and disease-modifying therapies are associated with the rate of disability accumulation in patients with... | Find, read and cite all the research you n...
researchgate.net
Anti-CD20 B cell depletion is associated with elevated mucosal-originating circulating regulatory IgA B cells in multiple sclerosis www.science.org/doi/10.1126/...
Anti-CD20 B cell depletion is associated with elevated mucosal-originating circulating regulatory IgA B cells in multiple sclerosis
Anti-CD20 B cell depletion augments mucosal regulatory IgA B cell trafficking in multiple sclerosis.
science.org
As a Doctor: What I do to Stay Healthy youtu.be/6rLtM5TqKwo?...
As a Doctor: What I do to Stay Healthy
YouTube video by Dr. Brandon Beaber
youtu.be
