Immune Profiling after treatment with an Anti-CD19 Chimeric Antigen Receptor T Cell Therapy in Treatment-Refractory Progressive Multiple Sclerosis Exciting new work from Sasha Gupta, Bruce Cree and colleagues! www.medrxiv.org/content/10.6...

Immune Profiling after treatment with an Anti-CD19 Chimeric Antigen Receptor T Cell Therapy in Treatment-Refractory Progressive Multiple Sclerosis

Treatment targeting progressive multiple sclerosis (MS) have limited efficacy, as central nervous system (CNS) resident B cells are resistant to peripheral B cell depletion by antiCD20 monoclonal anti...

medrxiv.org

Opinion @cp-trendsimmuno.bsky.social Understanding HLA risk in immune-mediated inflammatory diseases requires antigen discovery www.cell.com/trends/immun...

Multimodal discovery of a pathogenic B cell-dependent T cell state in multiple sclerosis academic.oup.com/brain/advanc...

Multimodal discovery of a pathogenic B cell-dependent T cell state in multiple sclerosis

Farooq et al. show that B cell depletion in multiple sclerosis indirectly disrupts a proinflammatory-cytotoxic T cell state. Convergent evidence across dis

academic.oup.com

💙 #MOGAD update: The FDA granted Priority Review to Genentech’s application for Enspryng® (satralizumab). In Phase III, it reduced relapse risk by 68%. If approved, it could be the first FDA-approved MOGAD treatment. Decision expected Jan. 10, 2027. www.gene.com/media/press-...

Marked benefit of Covid updated or booster vaccination in people with autoimmune conditions Real world evidence for over 60,000 individuals with major (40-70%) reduction of hospitalization acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Updated <fc>COVID</fc>‐19 Vaccines and Health Outcomes in Patients With Autoimmune Rheumatic Conditions

Objective We aimed to assess the association between COVID-19 vaccination status and COVID-19-related hospital admissions, need for mechanical ventilation or extracorporeal membrane oxygenation (ECM...

acrjournals.onlinelibrary.wiley.com

For people with multiple sclerosis with asymptomatic active lesions on MRI, dose high dose steroid treatment reduce conversion to a "black hole" on MRI, indicating irreversible axonal damage? According to this randomized trial, no! It makes no difference pubmed.ncbi.nlm.nih.gov/42711838/

Evaluation of MRI asymptomatic gadolinium-enhancing lesions conversion to persistent black hole with high‑dose methylprednisolone pulse therapy in relapsing remitting multiple sclerosis patients: a randomized trial - PubMed

Intravenous methylprednisolone pulse therapy administered for asymptomatic gadolinium-enhancing lesions was not associated with a statistically significant reduction in the formation of chronic T1 black holes over a 6-month follow-up period.

pubmed.ncbi.nlm.nih.gov

NIH to continue discussing only the top 1/3 of applications. This is a disservice to the research community. Fewer applications will get the higher quality of review from discussion. Applicants will get less nuanced feedback from review. grants.nih.gov/grants/guide...

Peptide-coupled red blood cells emerge as a promising autologous cell therapy for achieving antigen-specific immune tolerance in multiple sclerosis in a clinical trial of 10 patients. In PNAS: https://ow.ly/IkYP50ZKHUf

Intestinal infections establish antigen-specific, long-lived memory CD4+ T cells in the brain and meninges www.nature.com/articles/s41...

Intestinal infections establish antigen-specific, long-lived memory CD4+ T cells in the brain and meninges - Nature Neuroscience

Intestinal CD4+ T cells migrate to the dura and brain following gut infection with bacteria or parasites, establishing a long-lived memory population capable of proliferation and cytokine production f...

nature.com

Epstein–Barr virus and multiple sclerosis: Mechanisms, therapeutic implications, and emerging interventions www.sciencedirect.com/science/arti...

Understanding HLA risk in immune-mediated inflammatory diseases requires antigen discovery https://pubmed.ncbi.nlm.nih.gov/42705941/

Evolving role of CD8+ tissue-resident memory T cells in autoimmune and immune mediated inflammatory diseases: linking pathogenesis to therapeutic approaches www.frontiersin.org/journals/imm...

Frontiers | Evolving role of CD8+ tissue-resident memory T cells in autoimmune and immune mediated inflammatory diseases: linking pathogenesis to therapeutic approaches

Memory CD8+ T cells provide accelerated protection against intracellular pathogens and tumors. Circulating memory T cells recirculate through blood and lymph...

frontiersin.org

🚨 The NIH is moving to transfer hundreds of millions of dollars in infectious-disease research projects to the DOD under a secret 10-year pact. Here’s what’s happening inside “Operation Prevailing Edge” 🧵👇 www.nature.com/articles/d41...

Revealed: inside the US military's plan to tap huge sums from the NIH

An agreement paves the way for hundreds of millions of dollars’ worth of projects to be transferred from the NIH’s institute for infectious diseases to the Department of Defense.

nature.com

We’re proud to lead a $9 million effort to crack one of #myocarditis’ biggest mysteries: Why immune cells attack the heart. The long-term goal is "turning off the T cells attacking the heart while leaving the rest of the immune system intact," Dr. Josiah Gerdts explains. https://ucsfh.org/4qKxd3o

Under pressure, the DOD just released the text of its secret 10-year agreement with the NIH. Here are the biggest revelations from the document 🧵

TCR specificity prediction is advancing rapidly. The central question is not only which TCR sequence recognizes an antigen, but also which TCR pairings make recognition possible & where is the binding boundary? Our new paper tackles these questions. 🧵 www.science.org/doi/10.1126/...

Uneven TCR chain pairing constraints govern epitope recognition

Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope reco...

science.org

#For #TCR #Lovers look at this #great paper @pgtimmune.bsky.social Uneven TCR chain pairing constraints govern epitope recognition | Science www.science.org/doi/10.1126/...

Uneven TCR chain pairing constraints govern epitope recognition

Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope reco...

science.org

Lentiviral In Vivo CD19 CAR T-Cell Therapy in Neurologic Autoimmune Disorders @nejm.org www.nejm.org/doi/full/10....

📢 DPhil opportunity in our lab at @ox.ac.uk! We’re looking for a DPhil student to build a population-scale HLA–TCR atlas and investigate how genetic variation shapes human T-cell responses across health and disease. 🧬🦠 Apply before: *1 Dec 2026*. www.kennedy.ox.ac.uk/study-with-u...

Treatment of multiple sclerosis with peptide-coupled red blood cells induces antigen-specific T regulatory cells www.pnas.org/doi/abs/10.1...

Treatment of multiple sclerosis with peptide-coupled red blood cells induces antigen-specific T regulatory cells | PNAS

Inducing antigen-specific immune tolerance is a long-standing aim in organ-specific autoimmune diseases including multiple sclerosis (MS). We devel...

pnas.org

Our lab anticipate having #two #postdoctoral #positions starting beginning/late summer #2027. We are searching for candidates with #Tcell #expertise #protein #engineering and #ThymicTcellDevelopment.

🚨If you are a CA resident, please be aware of Prop 38, which is on the ballot this Nov. This initiative will provide $8.4 billion to advance breakthrough immunology research and treatments w/ half the funds dedicated to Alzheimer’s, cancer, and heart disease 1/

Proteome-Wide Antigen Discovery Reveals Compartment-Specific Humoral Responses in Coccidioidomycosis Congratulations to Christine Boutros, Michael Wilson and colleagues! www.medrxiv.org/content/10.6...

Proteome-Wide Antigen Discovery Reveals Compartment-Specific Humoral Responses in Coccidioidomycosis

Coccidioidomycosis is a fungal infection of rising public health concern, with coccidioidal meningitis (CM) representing its most devastating manifestation. Diagnosis of CM remains challenging due to ...

medrxiv.org

Why your doctor can't give you a cure tomorrow: how effective treatments are discovered and developed. Part 1 🧪 🧵 #science #news #education #health #research

Two post-doc positions available in our lab! It is a supportive environment and on which boosts careers! Historically, of our ~30 post-docs 27% have gone on to tenure-track positions, 27% did another post-doc, and 42% have gone on to positions in biotech or pharma.

Antibodies against MLC1 found in patients with NMOSD-like disease mediate astrocytopathy in rodent models www.science.org/doi/10.1126/...

Antibodies against MLC1 found in patients with NMOSD-like disease mediate astrocytopathy in rodent models

MLC1 antibodies are detected in a subset of patients with NMOSD-like disease and mediate astrocytopathy in rat encephalitis and mouse slices.

science.org

Lytic Epstein-Barr virus infection and emerging autoantibodies precede multiple sclerosis prodrome academic.oup.com/brain/advanc...

Lytic Epstein-Barr virus infection and emerging autoantibodies precede multiple sclerosis prodrome

By linking registries with biobanks, Grut et al. identify pre-symptomatic blood samples from individuals who later developed MS, and show that more extensi

academic.oup.com

How does the #immune system’s battle with viruses change as we age?🦠👶➡️👵 Our #JGenVirol Review explores how aging & a lifetime of viral exposures shape immunity, viral protection&vaccination in older adults–a🧵⬇️ go.unimelb.edu.au/or2h @jagaevert.bsky.social @microbiologysociety.org @mcri.bsky.social

Hi Internet! I'm Drew and THIS IS MY FACE. If this GIF has ever brought you joy in the past, I humbly ask you to consider making a donation to the National MS Society. It would mean a lot to me and to those I know affected by the disease! Donate at blinkingguy.com

Optimist: The cup is half full. Pessimist: The cup is half empty. Reviewer #2: You are using the wrong cup and your water is from the wrong source. Further, you are not qualified to handle cups or drink water.

Daniel Williams@daniel-williams.co.uk · 3w ago

Optimist: The cup is half full. Pessimist: The cup is half empty. Cosmologist: The cup is expanding in all directions all of the time. We don't know how fast it's happening, and our measurements all seem to contradict each other.