Brant Isakson
@brantisakson.bsky.social
How do cells in the microcirculation talk? That’s my jam. Also known as @conn_pann_fun on ol’ Twitter. I’ve been at UVA a lonnnnng time. ♥️🦕 physiology
Our review on Potassium Channels in Vascular Smooth Muscle Cells is out at Physiological Reviews. More than 150 pages long and citing more than 1500 articles, this herculean effort was co-authored by Tessa Garrud and Dan Collier. journals.physiology.org/doi/full/10....
Why travel to Denmark to collect samples from a giraffe's heart? @brantisakson.bsky.social lab members Skylar Loeb and @lukedunaway.bsky.social made the trip to learn more about diastolic heart failure. Red more: www.cvrc.virginia.edu/cvrc-trainee... #cardiology #medsky
CVRC Trainees Travel Abroad to Collect a Giraffe Heart – Robert M. Berne Cardiovascular Research Center
cvrc.virginia.edu
Excited to pre-release the latest from the lab on how arterial myocyte Panx1 controls vascular reactivity in diabetes. Massive effort from the M&M Team in collaboration with @brantisakson.bsky.social and Xiang Lab
Miguel Martín-Aragón Baudel@miguelmab.bsky.social · last yr.Check our latest work from the M&M lab on the role of SMC Pannexin 1 in diabetic hyperglycemia! And thanks to everyone involved in this! Ole 💃 www.ahajournals.org/doi/10.1161/...
Happy Donut Friday—Love the Cville Donut selections! 🍩
Our first giraffe heart acquisition has caused an epic Isakson Lab Slack blowup this morning 🦒🦒
Headed to #APS2025! Two great talks tomorrow from the Isakson Lab in the MCS session. Wyatt Shug (8:30AM) will present on basophil-endothelial crosstalk, and Skylar Loeb (10:50AM) will present the novel identification and impact of hemoglobin-alpha in cardiac lymphatics. @brantisakson.bsky.social
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Opinion | Science Suffers With Trump’s Funding Freeze
America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.
wsj.com
Some of the strong work by Melissa Luse rounding her PhD. Love the story, and I think it opens up some new ideas in endothelial lipid handling and overall questions roles for NO… www.ahajournals.org/doi/10.1161/...
Nitrosation of CD36 Regulates Endothelial Function and Serum Lipids | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: During obesity, endothelial cells (ECs) become lipid laden, leading to endothelial dysfunction. We tested posttranslational modification on CD36 that may regulate EC lipid accumulation. ...
ahajournals.org
Want to stay current with cardiology at UVA? Check out our starter pack! If you're a cardiologist at UVA and want to be included in the list, DM us! go.bsky.app/3NVEjJ5
@lukedunaway.bsky.social, PhD, recently received an @americanheart.bsky.social Career Development Award to study iron's role in chronic kidney disease. Luke is a postdoc in @brantisakson.bsky.social's Lab and member of our Cardiovascular Training Program. Congratulations! #CardioSky #MedSky
Luke Dunaway, PhD, Wins AHA Award for Chronic Kidney Disease Research – Robert M. Berne Cardiovascular Research Center
cvrc.virginia.edu
Happy Donut Friday! C’ville’s very own Belle for the win…
some good distraction tonight from the political crazies
Qunkasaura is the last dinosaur described in Spain, a large titanosaur that lived alongside Lohuecotitan at the Lo Hueco site, in the province of Cuenca #paleoart
🦕🦕 I’m happy this fun little book is finally out exploring how the physiology of the sauropod dino helped contribute to its dominance on earth for so long. However, I think I’ll stick to my day job 😁 🦕🦕
Happy Donut Friday to these three! Zuza received an AHA for work on Piezo2, Wyatt received BOTH an AHA and a F31 for work on basophils, and Skylar received an F31 for work on lymphatic alpha globin! Honored to have them in lab! (Pic from 2024 NAVBO)
Delighted to share ongoing translation of our discovery that alpha globin-eNOS is a potent regulator of NO in endothelium. In this work, the mechanism is confirmed in humans with alpha thalassemia, and our HbaX peptide used to dilate sickle cell arteries n/🧵 www.ahajournals.org/doi/abs/10.1...
Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions | Circulation
BACKGROUND: Severe malaria is associated with impaired nitric oxide (NO) synthase (NOS)–dependent vasodilation, and reversal of this deficit improves survival in murine models. Malaria might have sele...
ahajournals.org
