🔥 NEW: Your blood vessels' calcium channels are secretly hitchhiking on microtubules 🚌 & in diabetes/hypertension, it goes haywire. 📜New paper from the team at @ucdavis.bsky.social, @ucdavispharm.bsky.social Check the thread for some cool movies 🎞️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

💊Check this out! Using human iPSC-derived sinoatrial node cells & 3D organoids, new study @CircAHA reveals how GLP1 directly accelerates the heart’s pacemaker. Collab with Lulu Ren (former @mcipucd.bsky.social) & Joe Wu's Lab @ucdavis.bsky.social www.ahajournals.org/doi/10.1161/...

Tirzepatide Regulates Pacemaker Function by Modulating cAMP and Calcium Dynamics in Human Sinoatrial Node Cells | Circulation

ahajournals.org

👋The fourth episode of our podcast series just dropped. navedolab.faculty.ucdavis.edu/podcasts/ This one identifies a tissue-specific signaling mechanism that distinguishes how heart and vascular muscles control calcium intake. Check out the paper here: ahajournals.org/doi/10.1161/...

Happy Monday everyone!!! Happy to share this book chapter by my awesome partner Made Nieves-Cintron and #MnMLab members on "Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome" Highly relevant topic these days!!! link.springer.com/chapter/10.1...

Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome

Metabolic syndrome (MetS) encompasses an interconnected set of risk factors, including abdominal obesity, insulin resistance, hypertension, dyslipidemia, and systemic inflammation, all of which signif...

link.springer.com

🚨Not all channels are created equal🚨 New work from our lab shows that PKA regulates vascular CaV1.2 via S1928 — NOT Rad — phosphorylation, overturning the assumption that cardiac and vascular channels are regulated the same way. www.ahajournals.org/doi/10.1161/...

Context-Dependent Control: PKA Regulation of Vascular CaV1.2 Requires S1928 not Rad Phosphorylation | Arteriosclerosis, Thrombosis, and Vascular Biology

ahajournals.org

The team went to the #biophysical and #modeling side to understand how the CaBP1 protein regulates L-type channels. Great collab with Jim Ames, Hell Lab & #MnMLab @ucdavis.bsky.social pubs.acs.org/doi/10.1021/...

Structural Insights into L-Type Voltage-Gated Ca2+ Channel (CaV1.2) Activation by CaBP1

The L-type voltage-gated Ca2+ channel (CaV1.2) controls gene expression, cardiac function, and neuronal excitability. Mutations in CaV1.2 that disrupt channel function are implicated in cardiac arrhyt...

pubs.acs.org

🩸 Plot twist! Nosebleeds in hereditary hemorrhagic telangiectasia aren't just leaky pipes - VSM that surround and control them are secretly breaking down too! New in @CircRes 🔥 Great collab @ucdavishealth.bsky.social with Rong Wang @ucsfhealth.bsky.social www.ahajournals.org/doi/10.1161/...

Arterial Endothelial Deletion of Alk1 Causes Severe Nosebleed by Impairing Nasal Smooth Muscle Cells | Circulation Research

ahajournals.org

Someone got really great news from @ahascience.bsky.social on his Career Development Award. Congrats Miguel!!! #proudmentors @ucdavis.bsky.social, @ucdavishealth.bsky.social

Check out our reviews on "Translating cardiovascular ion channel and Ca signalling mechanisms into therapeutic insights". Massive effort from junior investigators, emerging researchers & other leaders in the cardiovascular field. @ucdavis.bsky.social doi.org/10.1113/JP29...

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for acce....

doi.org

Just in time for the Holidays, our latest paper on how #amyloidbeta regulates the spatiotemporal properties of vascular L-type channels - implications for vascular function. Great work by Jade and team! @ucdavis.bsky.social, @ucdavishealth.bsky.social physoc.onlinelibrary.wiley.com/doi/10.1113/...

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

Abstract figure legend Amyloid-β1-42 (Aβ1-42) triggers a male-specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway invol...

physoc.onlinelibrary.wiley.com

Great way to start the final month of the year with the publication of this collaborative work on how dopamine regulates L-type channels in #neurons. www.science.org/doi/10.1126/... And we got the cover!!! @ucdavis.bsky.social, @ucdavishealth.bsky.social

Stimulation of Ca2+ channel CaV1.2 activity by dopamine signaling augments spatial working memory

Dopamine-induced phosphorylation of an L-type Ca2+ channel supports working memory in mice.

science.org

Happy Halloween and Happy Fluorescence Friday 🎃✨ #ScienceCostumes #FluorescenceFriday #SuperResolution #PALMSTORM #LabLife

🚨 We are recruiting postdocs! If you're interested in reproductive, stem cell/developmental biology, and/or women's health, please apply! 📝 Please repost! 🚩 More info here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Postdoctoral Scientist - Zhang Lab

Primary Work Address: One Shields Avenue, Davis, CA, 95616 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the discovery and s...

hhmi.wd1.myworkdayjobs.com

The third episode of our podcast series just dropped: navedolab.faculty.ucdavis.edu/podcasts/ This one focuses on our recent study examining vascular Panx1 channels and their role in vascular complications during diabetic hyperglycemia. Get the paper here: pubmed.ncbi.nlm.nih.gov/40636957/

Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia - PubMed

These results suggest a key role for Panx1 in controlling ATP signaling through the P2Y_11L/AC5/AKAP5/PKA/Ca_V1.2 axis in arterial myocytes. This Panx1-led complex modulates cAMP levels, Ca_V1.2 activity, and vascular reactivity in response to diabetic hyperglycemia. Th …

pubmed.ncbi.nlm.nih.gov

Excited and honored to present this webinar. Please join! 🎙️Webinar! Unlocking vascular disease connection through ion channel signaling 🗓 September 29th, 2025 🕒 Time: PDT 17:00 / CDT 19:00 / EDT 20:00 Register: tinyurl.com/yoluxuwf #VascularDisease #IonChannels #Webinar

Welcome! You are invited to join a webinar: Unlocking vascular disease connection through ion channel signaling. After registering, you will receive a confirmation email about joining the webinar.

Welcome! You are invited to join a webinar: Unlocking vascular disease connection through ion channel signaling. After registering, you will receive a confirmation email about joining the webinar.

tinyurl.com

The official release of our manuscript examining arterial myocyte Panx1 role in diabetic vascular dysfunction is out! Massive effort to uncover new mechanisms underlying vascular disease. Power of science! @ucdavis.bsky.social, @ucdavispharm.bsky.social www.ahajournals.org/doi/10.1161/...

Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research

BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...

ahajournals.org

A little bit late but I’m honored and humbled to have been selected back in May as the recipient of the 2025 @ucdavis.bsky.social, @ucdavishealth.bsky.social Research Award! This recognition belongs to the M&M Lab members!

Manning & Rivera et al. (www.jacc.org/doi/10.1016/...) show that pruning just a few capillaries in the SA node plunges the heart’s pacemaker into metabolic overdraft—slowing the rate and jacking up beat-to-beat variability. The physiological equivalent of running on fumes. @jaccjournals.bsky.social

Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF

jacc.org

Great way to start the week with the release of this collaborative work with students and Drs. Horne & Hell @ucdavispharm.bsky.social, @ucdavis.bsky.social. Get your copy now! www.cell.com/cell-reports...

Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity

Lee et al. show that OCT3 and PMAT transport norepinephrine (NE) into neurons to stimulate β2ARs that are in their interior. The ensuing phosphorylation of GluA1 on S845 by PKA drives AMPARs to the su...

cell.com

Excited to pre-release the latest from the lab on how arterial myocyte Panx1 controls vascular reactivity in diabetes. Massive effort from the M&M Team in collaboration with @brantisakson.bsky.social and Xiang Lab

Miguel Martín-Aragón Baudel@miguelmab.bsky.social · last yr.

Check our latest work from the M&M lab on the role of SMC Pannexin 1 in diabetic hyperglycemia! And thanks to everyone involved in this! Ole 💃 www.ahajournals.org/doi/10.1161/...

Check our latest work from the M&M lab on the role of SMC Pannexin 1 in diabetic hyperglycemia! And thanks to everyone involved in this! Ole 💃 www.ahajournals.org/doi/10.1161/...

Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research

BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...

ahajournals.org

United in discovery, stronger together!!! Great science happens when we gather to learn, support each other, & celebrate the power of collaboration & community at our Departmental Annual Retreat! Shout out to organizers Deborah, Elva, Nate, Hai, Matthew, Christina & Charlotte!

Discover the inspiring story of Jeff Hill, a @ucdavis.bsky.social alum who leveraged the training he received in #physiology to support USA Air Force pilots. MCIP provides the training so more people follow on Jeff's steps. youtu.be/KuM4RIB98T8?...

My 100: Jeffrey Hill, M.S. '79

YouTube video by UC Davis Graduate Studies

youtu.be

The second episode of our podcast series just dropped. navedolab.faculty.ucdavis.edu/podcasts/ This one highlights efforts of the Nieves-Cintron group to understand the effects of nicotine and tobacco products on vascular function. Check out the paper here: pubmed.ncbi.nlm.nih.gov/38805589/

🎉 Excited to share our new paper in Science Signaling on #brain #pericytes constriction and TRPC3 channel—now published, featured on the cover, and highlighted in a Focus by @vesselman.bsky.social 🧠🧪 Check it out: www.science.org/toc/signalin... @cuanschutz.bsky.social

Honored and humbled to have received the Berne Distinguished Lectureship Award from the @apsphysiology.bsky.social CV Section this past weekend. Thanks to all current and former M&M Lab members, collaborators, @ucdavis.bsky.social, @ucdavishealth.bsky.social, #NIH_NHLBI & @americanheart.bsky.social

A great start to the Basic Sciences Symposium celebrating Women’s History Month! Keynote speaker Dr. Martina Anto-Ocrah with event organizers! @roseedixon.bsky.social @hannahvoorhees.bsky.social @ucdavis.bsky.social

We’re excited to announce the launch of our new PMB podcast on Spotify, titled Physiology Talks. This channel utilizes AI podcasters and is designed to showcase the incredible research happening in PMB @ucdavis.bsky.social . Tune in to the Premier episode!🎤🔬 open.spotify.com/episode/1LwV...

Premier Episode

UC Davis PMB—Physiology Talks · Episode

open.spotify.com

We are trying something new to help our community understand the impact of the science they generously support. Check out Episode 1 of a new podcast series: navedolab.faculty.ucdavis.edu/podcasts/ Disclaimer: generated by AI, but I think you will thank me as I will be terrible at this 😆

Great audience and energy as we start the 8th @ucdavis.bsky.social Cardiovascular Symposium!!!