Are infraslow oscillations the missing link between sleep and Alzheimer's? https://www.biorxiv.org/content/10.64898/2026.04.09.717425v1
Brain and Sleep Research Laboratory
@bsrlaboratory.bsky.social
The Brain and Sleep Research Laboratory is a joint effort of Luisa de Vivo and Michele Bellesi to investigate the neurobiology of sleep and wakefulness
Happy to share our recent theoretical review Why do we sleepwalk? A noradrenergic hypothesis of NREM sleep parasomnias www.sciencedirect.com/science/arti...
Why do we sleepwalk? A noradrenergic hypothesis of NREM sleep parasomnias
Disorders of arousal (DOA), including sleepwalking, sleep terrors, and confusional arousals, are characterized by complex behaviors emerging from non-…
sciencedirect.com
Latest piece of the lab. We studied the effects of vestibular stimulation during sleep on synaptic plasticity and motor learning. Rocking-induced sleep enhancement promotes motor learning through transcriptional and synaptic remodelling rdcu.be/e8Paq
🧠💤 New lab paper in @pnas.org Sleep loss doesn’t just make neurons tired - it slows the communication between them. We show that chronic sleep loss impairs myelin integrity, slows neural signal conduction, and affects cognition & motor behavior. 👉 www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
A framework to determine active neurons and networks within the mouse brain reveals how brain activity changes over the course of the day journals.plos.org/plosbiology/...
A framework to determine active neurons and networks within the mouse brain reveals how brain activity changes over the course of the day
In this study the authors develop a computational pipeline to infer the molecular properties of c-FOS-labelled active neurons and analyze the networks they form. They use this pipeline to characterize...
journals.plos.org
Simultaneous EEG-PET-MRI identifies temporally coupled and spatially structured brain dynamics across wakefulness and NREM sleep www.nature.com/articles/s41...
Simultaneous EEG-PET-MRI identifies temporally coupled and spatially structured brain dynamics across wakefulness and NREM sleep - Nature Communications
Using simultaneous EEG-PET-MRI, this study reveals tightly coupled physiological dynamics during the descent from wakefulness into NREM sleep and identifies network-specific activity underlying sensor...
nature.com
Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference www.medrxiv.org/content/10.1...
Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference
Slow waves mediate restorative functions of non-rapid eye movement (NREM) sleep. To enhance slow wave activity (SWA, 0.5-4 Hz) non-invasively, we employed a novel neuromodulatory tool, Transcranial El...
medrxiv.org
💤🧠🧪 New article! 🧪🧠💤 After years of effort led by @qualiastructure.bsky.social (Nao Tsuchiya and William Wong), Jenny Windt, Katja Valli, Valdas Noreika and @rherzoga.bsky.social, the Dream database is now published in @natcomms.nature.com **A dream EEG and mentation database** rdcu.be/eAwni
Mitochondrial origins of the pressure to sleep www.nature.com/articles/s41...
Mitochondrial origins of the pressure to sleep - Nature
Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
nature.com
Neuroendocrine circuit for sleep-dependent growth hormone release: Cell www.cell.com/cell/fulltex...
Neuroendocrine circuit for sleep-dependent growth hormone release
The increase in growth hormone release during sleep is driven by sleep-wake-dependent activity of stimulatory GHRH neurons and inhibitory SST neurons in the hypothalamus. The released growth hormone e...
cell.com
A time window for memory consolidation during NREM sleep revealed by cAMP oscillation: Neuron www.cell.com/neuron/fullt...
A time window for memory consolidation during NREM sleep revealed by cAMP oscillation
Sleep is crucial for memory formation. Deng et al. find that cAMP levels in mice oscillate with a 1-min cycle during slow-wave sleep, and hippocampal activity at the peak of these oscillations is nece...
cell.com
Increased CSF drainage by non-invasive manipulation of cervical lymphatics www.nature.com/articles/s41...
Increased CSF drainage by non-invasive manipulation of cervical lymphatics - Nature
The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.
nature.com
The great brain clearance and dementia debate www.nature.com/articles/d41...
The great brain clearance and dementia debate
An established theory for how good sleep reduces a person’s risk of neurodegenerative disease has been called into question. The ensuing argument could have enormous consequences for the treatment of ...
nature.com
Global coordination of brain activity by the breathing cycle www.nature.com/articles/s41...
Global coordination of brain activity by the breathing cycle - Nature Reviews Neuroscience
Synchrony between neuronal activity and the respiratory cycle has been observed in numerous brain regions and across many species. Tort et al. discuss the mechanisms by which brain activity is modulat...
nature.com
Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep www.nature.com/articles/s41...
Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep - Nature Communications
Neural mechanisms underlying memory acquisition and encoding are not fully understood. Here authors show that during sleep, besides the replay of past memory, coactivity of a new set of cells arises (...
nature.com
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS
Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where in...
pnas.org
Reversible reduction in brain myelin content upon marathon running www.nature.com/articles/s42...
Reversible reduction in brain myelin content upon marathon running - Nature Metabolism
Using magnetic resonance imaging on marathon runners, Ramos-Cabrer, Cabrera-Zubizarreta et al. report that the signal detected as a surrogate of myelin content is significantly reduced after exercise,...
nature.com
Enhanced memory despite severe sleep loss in Drosophila insomniac mutants journals.plos.org/plosbiology/...
Enhanced memory despite severe sleep loss in Drosophila insomniac mutants
Sleep is known to support memory. In this study, the authors identify an instance where memory hyperfunction may actually provoke sleep deficits. They find that the short-sleep Drosophila mutants, ins...
journals.plos.org
Sleep pressure accumulates in a voltage-gated lipid peroxidation memory www.nature.com/articles/s41...
Sleep pressure accumulates in a voltage-gated lipid peroxidation memory - Nature
Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state o...
nature.com
Consciousness or pseudo-consciousness? A clash of two paradigms www.nature.com/articles/s41...
Consciousness or pseudo-consciousness? A clash of two paradigms - Nature Neuroscience
Integrated information theory (IIT) starts from consciousness, which is subjective, and accounts for its presence and quality in objective, testable terms. Attempts to label as ‘pseudoscientific’ a th...
nature.com
Pupil size reveals arousal level fluctuations in human sleep www.nature.com/articles/s41...
Pupil size reveals arousal level fluctuations in human sleep - Nature Communications
Arousal levels regulate sleep, but accurate noninvasive measures are lacking. Here, a novel method is introduced to track pupil-indexed arousal levels during human sleep, revealing pupil size changes ...
nature.com
A deep learning–enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life www.pnas.org/doi/10.1073/...
A deep learning–enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life | PNAS
In wearable smart systems, continuous monitoring and accurate classification of different sleep-related conditions are critical for enhancing sleep...
pnas.org
Our latest in PNAS! 🎉 ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep Take home message? KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions. www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS
Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where in...
pnas.org
Amygdalo-cortical dialogue underlies memory enhancement by emotional association: Neuron www.cell.com/neuron/fullt...
Amygdalo-cortical dialogue underlies memory enhancement by emotional association
How does emotion prioritize associated memory? Saito et al. show that emotional association enhances perceptual memory retention and amygdalo-cortical coordination during learning and early-NREM sleep...
cell.com
Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer’s mouse model: iScience www.cell.com/iscience/ful...
Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer’s mouse model
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, beta-amyloid plaques, and tau tangles. Growing evidence suggests a strong link between sleep disturbances a...
cell.com
Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice www.nature.com/articles/s42...
Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice - Nature Metabolism
Scott, Tan et al. characterize the neural circuits that link mechanic stimuli in the heart and gut with whole-body energy homeostasis and vigilance.
nature.com
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep www.sciencedirect.com/science/arti...
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
As the brain transitions from wakefulness to sleep, processing of external information diminishes while restorative processes, such as glymphatic remo…
sciencedirect.com
Individualized temporal patterns drive human sleep spindle timing www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
Memory control deficits in the sleep-deprived human brain www.pnas.org/doi/10.1073/...
Memory control deficits in the sleep-deprived human brain | PNAS
Sleep disturbances are associated with intrusive memories, but the neurocognitive mechanisms underpinning this relationship are poorly understood. ...
pnas.org
