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Shannon Macauley

@macauleylab.bsky.social

Associate Prof, PhD, wife, mom. Alzheimer’s disease | metabolism | sleep| glia | I ❤️ lactate | macauleylab.com **views are mine, not my employer**

545 Posts2825 Follower1032 Folgt
UK Sanders-Brown Center on Aging@uksbcoa.bsky.social · 2w ago

Previously, scientists believed that sleep loss in Alzheimer’s was caused by dying neurons or the physical clutter of amyloid plaques. However, findings from the @macauleylab.bsky.social suggest the problem is a “whole house response” scenario. @ukresearch.bsky.social

Two hours of sleep restored: UK researchers make Alzheimer’s breakthrough

In a study published in the journal Alzheimer’s & Dementia, a team led by Shannon L. Macauley, Ph.D., an associate professor of physiology in the UK College of Medicine, and first author Nicholas ...

uknow.uky.edu

I-75 Scientist@flscitriguy.bsky.social · last mo.

Ok, it's getting to be about a month out from the next F3# due dates. Students, when contacting a program officer about fit, send a draft of your specific aims page. Yes, the whole page. Context of your project is important. The elevator pitch in an email is less helpful.

Shannon Macauley@macauleylab.bsky.social · 3mo ago

New Paper Alert! From @clairashley.bsky.social in the lab! Alzheimer’s disease isn’t just protein aggregation. It’s an immunometabolic disorder. Our new work shows: 👉 Lactate is not a byproduct 👉 It’s a driver of microglial dysfunction and Aβ dynamics link.springer.com/article/10.1...

Lactate metabolism links reactive microglia, amyloid pathology, and Aβ dynamics - Journal of Neuroinflammation

Journal of Neuroinflammation - Alzheimer’s disease (AD) is increasingly recognized as a disorder of early immunometabolic dysfunction, yet how amyloid-β (Aβ) pathology reshapes...

link.springer.com

Melissa Cooper, PhD@melcooperphd.bsky.social · 4mo ago

Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!

Astrocytes connect specific brain regions through plastic networks - Nature

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

nature.com

Nature Portfolio@natureportfolio.nature.com · 4mo ago

A study in Nature Aging shows that the strongest Alzheimer’s Disease risk gene, APOE4, can make certain brain cells in young mice hyperactive, which can predict later memory decline. The study also implicates Nell2 protein as a contributor to APOE4-driven dysfunction. #Alzsky 🧬🧪

Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer’s disease pathogenesis - Nature Aging

Young, cognitively normal APOE4 mice display hippocampal network hyperactivity that predicts later memory decline. This phenotype is driven by neuronal APOE4 expression, which causes hyperexcitability of hippocampal neurons and can be reversed by targeting Nell2.

go.nature.com

Nature Medicine@natmed.nature.com · 5mo ago

In this phase 2, randomized trial in early #Alzheimers disease, the #TREM2 agonistic antibody AL002 showed target engagement but did not meet the primary endpoint of change from baseline in Clinical Dementia Rating-Sum of Boxes. #microglia #AD https://www.nature.com/articles/s41591-026-04273-1

The TREM2 agonistic antibody AL002 in early Alzheimer’s disease: a phase 2 randomized trial - Nature Medicine

In this phase 2, randomized trial in early Alzheimer’s disease, the TREM2 agonistic antibody AL002 showed target engagement but did not meet the primary endpoint of change from baseline in Clinical Dementia Rating-Sum of Boxes score.

nature.com

Shannon Macauley@macauleylab.bsky.social · 5mo ago

Proud to have our work on tau, metabolism, and sleep highlighted by the University of Kentucky! Thanks again to the NIH, CART Fund, and @brightfocus.bsky.social for supporting our work. uknow.uky.edu/research/uk-...

UK researchers discover brain’s energy ‘hijacked’ by Alzheimer’s protein

Scientists at the University of Kentucky have uncovered a new reason why people with Alzheimer’s disease often struggle with sleep, long before memory loss begins. The study, led by researchers at the...

uknow.uky.edu

Jeremy Berg@jeremymberg.bsky.social · 5mo ago

New and Competitive Renewals Only 803 grants have been made compared to ~2650 in fiscal years 2023 and 2024 through February 20. All institutes and centers (include OD now) have made awards except NIAAA, NLM, NCCIH, and FIC. 3/4

Line graph of the number new and competitive renewal grants funded by NIH in fiscal year 2026 through February 20, compared to fiscal years 2020-2025. The fiscal year 2026 is well below the other curves.