What I love most about this paper is not only the science but how it harnessed the collaborative energy of two amazing lab mates to create something really special. What a week by @juliabrunner.bsky.social 🥳

Julia S. Brunner@juliabrunner.bsky.social · 5mo ago

One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...

Absolutely gorgeous and meticulous work from @juliabrunner.bsky.social that has been so fun to brainstorm about over the years. Another important reminder that even ‘core’ metabolic pathways are often differentially wired across cell states!

Julia S. Brunner@juliabrunner.bsky.social · 5mo ago

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

I'm excited to share our latest story from the @lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Intracellular metabolic gradients dictate dependence on exogenous pyruvate

Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...

rdcu.be

Thrilled that my thesis work in @lydiafinley.bsky.social's lab is out in the world! We found that methotrexate targets a specific metabolic vulnerability in a particularly aggressive form of pediatric rhabdomyosarcoma. Thank you to everyone who contributed to this project over the years!

bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 2y ago

PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma https://www.biorxiv.org/content/10.1101/2025.01.15.633227v1

Our latest preprint identifies (targetable!) metabolic programs intrinsic to different cancer cell states in rhabdomyosarcoma, out just in time for @katrinaparas.bsky.social's thesis defense tomorrow!

bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 2y ago

PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma https://www.biorxiv.org/content/10.1101/2025.01.15.633227v1

Thrilled that my first post here is this absolutely monumental work by @katrinaparas.bsky.social and the @lydiafinley.bsky.social lab. It’s been so much fun to watch this story develop; read it if you have any interest in cell state, pediatric cancer, or of course metabolism!

bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 2y ago

PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma https://www.biorxiv.org/content/10.1101/2025.01.15.633227v1