Check out our Spotlight in Molecular Cell on @lydiafinley.bsky.social's lab recent work on Aconitase 2 and its protective role against impaired cell fitness and ISR activation due to mitochondrial citrate accumulation authors.elsevier.com/c/1n3Nn3vVUP...

1st McKinley Lab grad student’s 1st preprint! @claireang.bsky.social studied how the uterus safely excises massive amounts of tissue during menstruation and pregnancy. Come for her GORGEOUS images, stay for her incredible discoveries. www.biorxiv.org/content/10.6... w/ @akelleher1017.bsky.social

Claire Ang@claireang.bsky.social · 5mo ago

Excited to share my new preprint from the McKinley lab, where we explored regenerative mechanisms across menstruation and pregnancy! We thought specialized glands would regenerate everything. We were wrong. But the real mechanism turned out to be way cooler :) 🧪🧵 www.biorxiv.org/content/10.6...

#NatMetabPicks | In @cp-cell.bsky.social led by @lydiafinley.bsky.social ( @mskcancercenter.bsky.social ) 🧪 Citrate clearance is an essential function of the TCA cycle via the activity of aconitase 2. www.cell.com/cell/fulltex...

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

cell.com

Now online! Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increase, aconitase 2 becomes essential to prevent mitochondrial citrate accumulation, which can trigger the integrated stress response and impair cell fitness.

dlvr.it

Congrats (again) to Julia and Abby for their collaborative effort asking when and why cells use the TCA cycle. TLDR; it's not just about ATP or making nutrients-- the TCA cycle is also important to remove nutrients!

Julia S. Brunner@juliabrunner.bsky.social · 6mo ago

One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...

HUGE congratulations to our very own Julia Brunner for her paper describing cell-state dependent engagement of the malate-aspartate shuttle, out today!! Many thanks to all lab members, funders, and colleagues who supported the work, and stay tuned for more from Julia very soon!

Julia S. Brunner@juliabrunner.bsky.social · 6mo ago

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

We are hiring a postdoc! The group has a funded opening to join our amazing team on the NCI's Frederick, MD campus. This is an opportunity to train in cutting-edge chemical & RNA biology methods with a supportive, tight-knit group. Link to posting below. Please share! jobrxiv.org/job/national...

📣 First preprint from the TeSlaa lab 📣 We investigated how methyl-rich nutrient, choline, is used in the body and how systemic one-carbon metabolism responds to dietary methyl-donor deficiency. www.biorxiv.org/content/10.6...

🍰Read also the Research Briefing here: 👉https://rdcu.be/e3tiZ bit.ly/404rclA

A p53-controlled lysosomal recycling circuit fuels phospholipid synthesis - Nature Cell Biology

The transcription factor p53 enables phosphoethanolamine scavenging to support increased membrane phospholipid synthesis during senescence. Perturbing lipid synthesis or recycling compromises the fitn...

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☕Yashinskie, Zhu et al show that #p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of #autophagy and lysosomal catabolism programmes and increased reliance on lipid headgroup recycling. @lydiafinley.bsky.social bit.ly/4asbwO3

p53 increases phospholipid headgroup scavenging in senescence - Nature Cell Biology

Yashinskie, Zhu and colleagues show that p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of autophagy and lysosomal catabolism programmes and in...

bit.ly

Lab’s 1st preprint! Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate. @cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation. He is on the job market!

Çağrı Çevrim@cagricevrim.bsky.social · 10mo ago

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉 @karalmckinley.bsky.social We built the first transgenic model of menstruation in mice. We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪 www.biorxiv.org/content/10.1... 🧵

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

Check out the symposium organized by our CoE, excited to have Marcia Haigis, @lydiafinley.bsky.social, Matthias Hebrok and Tom MacVicar over in Helsinki in November. Sign up by October 22nd 👇

MetaStem@metastem.bsky.social · 11mo ago

Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social

Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social Here is a short paper thread. #tuberculosis #macrophages 🦠 www.biorxiv.org/content/10.1...

Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense

M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...

biorxiv.org

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social jci.org/articles/vie... 1/6

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism

Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

nature.com

Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out! Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...

Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma

Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.

science.org

ICYMI:

Intracellular metabolic gradients dictate dependence on exogenous pyruvate

Nature Metabolism, Published online: 28 April 2025; doi:10.1038/s42255-025-01289-8Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a key metabolite in central carbon metabolism.

bit.ly

I'm excited to share our latest story from the @lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Intracellular metabolic gradients dictate dependence on exogenous pyruvate

Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...

rdcu.be

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com A thread 🧵 1/9

Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications

Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

nature.com

Showcase your research! Submit your poster abstract by April 16 (11:59pm MST) to join speakers @lydiafinley.bsky.social, Ralph J. DeBeradinis, & Keynote Navdeep Chandel. Apply now: keysym.us/KSMetabDev25. Can't attend? Access insights On Demand for 6 months post-conference! #KSMetabDev25 #cellfate

2 weeks to go to the annual NYAS cancer metabolism symposium, April 8 at NYU Langone! www.nyas.org/shaping-scie... Register now using code CancerMetabolism10 for a 10% discount. And hurry! Last year we sold out! cc: @lyssiotislab.bsky.social @marcusgon.bsky.social

Cancer Metabolism and Signaling in the Tumor Microenvironment - NYAS

April 8, 2025 | 9:00 AM – 5:00 PM ET Join leading experts at the forefront of cancer metabolism research for a one-day event on April 8, 2025, in New York City. The New York Academy of Sciences invite...

nyas.org

www.quantamagazine.org/how-metaboli... Seems like a good time to remind you of an upcoming meeting on this exact topic: www.keystonesymposia.org/conferences/...

How Metabolism Can Shape Cells’ Destinies | Quanta Magazine

A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life.

quantamagazine.org

We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for: Exciting science ✅ Awesome speakers ✅ Great camaraderie ✅ Science jokes⚠️ Celebrity appearances‼️ (probably not) Please circulate 🔁 events.nyas.org/event/16a78a...

Unlock $200 in savings on Metabolic and Nutritional Control by registering before 11:59 PM MST on March 20! Don't miss the chance to hear from @lydiafinley.bsky.social this May in Beverly, MA, USA. Secure your spot now: keysym.us/KSMetabDev25. #KSMetabDev25 #metabolism youtu.be/le7D7qpo4sM

KSQA: Dr. Lydia Finley (Metabolic and Nutritional Control)

YouTube video by KeystoneSymposia

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1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social www.science.org/doi/10.1126/...

Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.

science.org

New preprint time!! This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way. www.biorxiv.org/content/10.1...

A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression

Hyperactive WNT signaling is a potent cancer driver, but clinical translation of WNT inhibitors has been hampered on-target toxicities. WNT signaling can be constrained through inhibition of the PARP ...

biorxiv.org

Metabolic & Nutritional Control of Development and Cell Fate is just around the corner. Register by March 20 (11:59pm MST) and snag a $200 discount! Don't miss our incredible speaker lineup! 👉 keysym.us/KSMetabDev25. #KSMetabDev25 youtu.be/CSto4rJv40I @lydiafinley.bsky.social @rjdlab.bsky.social

Metabolic and Nutritional Control Meeting Promo

YouTube video by KeystoneSymposia

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📢3 weeks left to submit your abstract for the Cancer Metabolism Showcase and Workshop!📢 We already have over 150 registrants! Sign up for free today at www.cancermetabolismshowcase.org