Excited to share our preprint using time-resolved small-angle X-ray diffraction to study myosin motor conformations during isometric twitch and tetanus contractions in the slow-twitch rat soleus skeletal muscle #myoblue

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 12mo ago

Distinct distributions of myosin motor conformations during contraction of slow and fast skeletal muscle https://www.biorxiv.org/content/10.1101/2025.10.13.679501v1

There is still time for ECA members to apply for travel awards to #EMC2025. Applications are now being recieved until 06/06/25

European Society for Muscle Research Early Careers Association@esmreca.bsky.social · last yr.

The European Muscle Conference 2025 website is now live! www.emc2025amsterdam.com The ECA have a number of travel awards available for ECR's attending. We will be hosting an online meeting on 14/05/25 at 1600 CET to provide further information about the travel awards, so come along for more info

The European Muscle Conference 2025 website is now live! www.emc2025amsterdam.com The ECA have a number of travel awards available for ECR's attending. We will be hosting an online meeting on 14/05/25 at 1600 CET to provide further information about the travel awards, so come along for more info

Some really kind words and interesting perspectives from @hesselanthony.bsky.social on our paper published in @pnas.org. (www.pnas.org/doi/10.1073/...). Anthony sheds some light on why there are exciting times ahead for the muscle X-ray diffraction community!

Anthony Hessel, PhD@hesselanthony.bsky.social · last yr.

🚨📢It was great to write a commentary about the great science conducted by @cameronhill13.bsky.social. Time-resolved function-molecular structure of intact muscle (ex vivo)! Popping the hood of muscle motors using time-resolved, small-angle X-ray diffraction | PNAS www.pnas.org/doi/10.1073/...

The final piece of the puzzle for my PhD thesis, currently under review. We looked at the trajectory of age-related serial sarcomere loss across young (8 mo), middle-aged (20 mo), old (32 mo), and very old rats (36 mo) in 5 different muscles. A simple study but it provided a lot of cool insight!

Geoff Power@geoffpower.bsky.social · 2y ago

We investigated serial sarcomere loss as a contributor to the age-related loss of muscle mass across four aging timepoints SSN loss contributed to the loss of muscle mass. Increasing SSN is a target for improving muscle performance in old age. @hinksave.bsky.social www.biorxiv.org/content/10.1...

For a bite-sized summary of our main findings @esrf.fr have kindly written a brief overview of our paper: www.esrf.fr/home/news/ge... #myoblue

This has been a long time in the making but I am absolutely delighted to share our latest paper published in @pnas.org where we use time-resolved X-ray diffraction to elucidate the regulatory roles of the thick and thin filaments during muscle relaxation #myoblue www.pnas.org/doi/10.1073/...

Dual-filament regulation of relaxation in mammalian fast skeletal muscle | PNAS

Muscle contraction is driven by myosin motors from the thick filaments pulling on the actin-containing thin filaments of the sarcomere, and it is r...

pnas.org

The meeting can be accessed via the below link: duke.zoom.us/j/91574693682 (Meeting ID: 915 7469 3682)

The Early Careers Association of the European Society for Muscle Research invite you to join us for our 5th annual ECA online event titled "Muscle Research Between Academia and Industry" with talks from Dr Sinead Roberts @sineadrobert and Dr Valentin Burkart on 26th March 2025 at 1600 CET

🚨📢Paper alert! Real progress on identifying why residual force enhancement occurs in skeletal muscle! This was a study I dreamed about since grad school. Please share! 🔬💪🧪 www.pnas.org/doi/10.1073/...

First foray into Bluesky. Lets kick things off by sharing our latest paper recently published in @jphysiol.bsky.social from the Brunello lab at King's College London where we used time-resolved X-ray diffraction to study load-dependence for the activation of myosin motors in cardiac muscle

Load‐dependence of the activation of myosin filaments in heart muscle

Abstract figure legend Load-dependent activation of cardiac myosin filaments. We used synchrotron, time-resolved, small-angle X-ray diffraction to investigate structural dynamics in the myosin-contai...

physoc.onlinelibrary.wiley.com