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Cardoso lab

@cardosolab.bsky.social

Cell Biology and Epigenetics https://www.bio.tu-darmstadt.de/fachbereich_01/personen/bio_kontakt_details_3200.de.jsp

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Cardoso lab@cardosolab.bsky.social · last mo.

🧬 New preprint! When replication forks stall, the replisome doesn't just wait. Live-cell imaging of endogenously GFP-tagged factors shows polymerases pile up even with DNA synthesis blocked — because dormant origins fire right next to stalled forks. doi.org/10.64898/202... www.cardoso-lab.org

Dynamic anatomy of the replisome under stress

When exposed to replication stress, the factors involved in DNA replication display differing responses that in many cases remain unexplained. In this study, we generated a series of genomically engin...

doi.org

Cardoso lab@cardosolab.bsky.social · 2mo ago

New review in NAR! We connect the two halves of the DNA replication field — single-cell microscopy and genome-wide sequencing to show how each method’s strengths build one picture: from DNA fibers → replication foci → origin & timing maps. 🔗 doi.org/10.1093/nar/gkag550 @narjournal.bsky.social

Spatial organization and dynamics of genome replication: from forks to foci

Abstract. Genome replication is without doubt the most complex and critical activity of all living cells. Any error may not only affect the cell itself but

doi.org

Cardoso lab@cardosolab.bsky.social · 9mo ago

Our new work in EMBO Reports! 🧬 H3K36me3 enriches at pericentromeric heterochromatin BEFORE replication, regulating its timing. H3K36me3 loss disrupts satellite transcription and delays replication. Forward-strand MajSat RNA controls replication timing—ncRNAs as key regulators! cardoso-lab.org

Cardoso lab@cardosolab.bsky.social · last yr.

🧬⚡Your sunscreen is only half the story We show that near-infrared light makes UV damage WORSE. nIR loosens DNA packaging, creating a repair traffic jam that increases breaks. We are ignoring the invisible majority of solar radiation that hacks DNA repair. doi.org/10.1038/s415... @tuda.bsky.social

Exposure of cells to near-infrared irradiation relaxes chromatin compaction and facilitates recognition of cyclo-butane pyrimidine dimers - Scientific Reports

Scientific Reports - Exposure of cells to near-infrared irradiation relaxes chromatin compaction and facilitates recognition of cyclo-butane pyrimidine dimers

doi.org

Cardoso lab@cardosolab.bsky.social · last yr.

Our new paper is out: we explored the role KAP1 and HP1alpha in retroviral elements silencing. Check it out: doi.org/10.1038/s414... cardoso-lab.org/pages/public... @tuda.bsky.social @synbio.bsky.social

The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells - Nature Communications

Silencing of endogenous retroviral elements (ERVs) is mediated by KAP1. Here, the authors describe the molecular mechanism by which KAP1 induces structural reorganization and multimerization of HP1α a...

doi.org