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Catherine Hall

@cathnaledi.bsky.social

Professor of Neurovascular stuff at Sussex Uni and UCL. My lab researches how the brain controls its blood flow. Also at @catherinenhall@mas.to and @cathnaledi on what-was-Twitter

68 Posts918 Follower1486 Folgt
Catherine Hall@cathnaledi.bsky.social · 4mo ago

This is super-interesting! What happens in non-arousal activity state shifts (eg reward)? How do populations relate to neurotransmitters produced in different cells? Can this explain why we see lower NVC in the hippocampus? (poss yes but doesn’t account for different capillary level responses).

Agnès Landemard@agnesland.bsky.social · 4mo ago

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states! Out today in Nature: rdcu.be/fdC2A @uclbrainscience.bsky.social

The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.
Neuron@cp-neuron.bsky.social · 9mo ago

The brain neurovascular epigenome and its association with dementia

Ziegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s disease and cerebral small vessel disease within neurovascular cells, identifying immune-related AD risk and broad neurovascular involvement in SVD. They highlight novel regulatory pathways and potential therapeutic targets, advancing understanding of these comorbid conditions for future treatment strategies.

dlvr.it

Silvia Anderle@silvia-anderle.bsky.social · last yr.

Delighted to share our latest review in Nature Reviews Neuroscience! We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies. www.nature.com/articles/s41...

The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience

Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

nature.com

Catherine Hall@cathnaledi.bsky.social · 12mo ago

Very excited that this is official now! Lots of setting up currently but will be recruiting soon!!

UK Dementia Research Institute@ukdri.ac.uk · last yr.

Delighted to welcome a new Group Leader to our flagship vascular dementia research centre with @thebhf.bsky.social 🎉👏 Prof Catherine Hall @cathnaledi.bsky.social and her team will examine how changes in blood flow & oxygen supply drive the onset of vascular dementia & Alzheimer’s👉 buff.ly/gyouoEV

Catherine Hall@cathnaledi.bsky.social · last yr.

I'm collating slides for our collaborator group lab Summer Symposium tomorrow. The brief is "cool things you learnt over the last year" and I cannot over-emphasise how optimistic I am about the future of science with this bunch of trainees' contributions!

Catherine Hall@cathnaledi.bsky.social · last yr.

Please consider supporting the Wildlife Trusts' purchase and work in the Rothbury Estate in Northumberland to create a huge wildlife corridor from the hills to the sea and protect species like the red squirrel and golden eagle. Donations currently match funded! donate.biggive.org/campaign/a05...

Rothbury Estate for Nature and the Nation – Big Give

Rothbury Estate offers a unique chance to create one of England’s largest nature recovery areas. By protecting its rich heritage, supporting local farmers and improving public access, The Wildlife Tru...

donate.biggive.org

Catherine Hall@cathnaledi.bsky.social · 2y ago

New paper led by @silvia-anderle.bsky.social Lifestyle matters for genetic Alzheimer’s disease risk: APOE4 reduces neurovascular function most in an already-stressed system,  when neurons are active and mice do less exercise. I'll tell you all about it! 🧪 #neuroscience #alzheimers rdcu.be/d74uh

APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice

Communications Biology - Lifestyle matters for genetic Alzheimer’s disease risk: In vivo imaging of mouse blood vessels and neurons shows that APOE4 reduces neurovascular function most in an...

rdcu.be