In today’s article, @kingsioppn.bsky.social Professor Cathryn Lewis @cathrynlewis.bsky.social discusses current evidence on the efficacy of #antidepressants and how research should move forward to support #precisionmedicine approaches in #mentalhealth. www.inspirethemind.org/post/underst...

Understanding who benefits from antidepressants

Why is the use of antidepressants so controversial, and how could we prescribe them more effectively? This question is a priority in my research at King’s College London, where I work as professor of ...

inspirethemind.org

Autumns has arrived - the @kingsioppn.bsky.social campuses are buzzing with new students but still sunny and mild enough for an early morning coffee outside at Ortus.

If your Monday morning is challenging, this post is a reminder of positive changes over the last 10 years. From cancer treatment to music access to dresses-with-pockets Hang in there amid the turmoil.

Molly Knight@mollyknight.bsky.social · 11mo ago

Please give me an unironic list of things that have gotten better over the last ten years because I’m spiraling. I’ll start: you can buy an enormous TV from Costco for like $100 bucks now.

🚨Come work with us!🚨 Open post for Clinical Psychology Lecturer, combining NHS clinical work with research and education at the SGDP Centre.

Thalia Eley@thaliaeley.bsky.social · last yr.

Delighted to be hiring a new Clinical Psychology Lecturer to come and join our vibrant environment at the SGDP Centre @kingsioppn.bsky.social @kingscollegelondon.bsky.social please share! my.corehr.com/pls/coreport...

Do you analyse #polygenic scores across ancestry groups? See Oliver Pain's extension to the GenoPred pipeline, with recommendations for good practice and efficient analysis. @oliverpain.bsky.social 🔗 Paper: lnkd.in/evJ9daBF 🔗 GenoPred pipeline: lnkd.in/eKwFr9kQ www.linkedin.com/posts/oliver...

🚨 My new paper is out! | Oliver Pain, PhD posted on the topic | LinkedIn

🚨 My new paper is out! 🧬 Improving polygenic score (PGS) accuracy and equity across ancestrally diverse populations — with and without individual-level tuning data.  I benchmarked leading single-sou...

linkedin.com

We're back, with a fresh new lineup of talks and workshops! Get your place while you still can to learn about how to make your research more robust and how to deal with scientific fraud! This event is free and open to all: tinyurl.com/3ewaduvm

🎉(1/4) Excited to share that our latest paper is now published! We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP. www.nature.com/articles/s41...

Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank - European Journal of Human Genetics

European Journal of Human Genetics - Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank

nature.com

This morning's email had *four* paper review requests - again. Important to contribute to keeping peer review moving. We have two papers languishing at journals for 6-9 months, with real impact on #ECR careers. Suggestions for short-term fixes to help this broken system? #academia #publishing

At @edinburghup.bsky.social University for two day AMBER team meeting. @wellcometrust.bsky.social project to identify the causal mechanisms underlying #antidepressants using informatics, genomics & cellular approaches.

(1/2) Only one-third of people taking antidepressants for depression respond to the first drug they are prescribed and we know little about WHICH drug will work for each patient.

Psychiatric Genomics Consortium (PGC)@pgcgenetics.bsky.social · last yr.

Day 4 of the 2nd Week of #MDD & #Anxiety takeover! How do genetic differences shape individual responses to treatment?This is what recent research has begun to investigate.. 💊

Women make up only 16% of corresponding authors who submit to Nature, a new Springer Nature analysis revealed. This is not enough - there are 30-40% #womeninSTEM We want to change it, through targeted editorial policies & outreach. But change will take everyone! 🧪 www.nature.com/articles/d41...

Gender equality in research publishing is a responsibility for everyone

A concerted effort is needed to support women in their choice of journal when submitting their manuscript.

nature.com

"This work is a first step in using health records to define and predict SSRI drug responses." - Professor Cathryn Lewis @cathrynlewis.bsky.social is Deputy Lead of our Trials, Genomics and Prediction theme, and the research was supported by @nihr.bsky.social and @wellcometrust.bsky.social 👇

Institute of Psychiatry, Psychology & Neuroscience@kingsioppn.bsky.social · last yr.

Who benefits from antidepressants? New research from IoPPN ( @cathrynlewis.bsky.social) and University of Edinburgh shows how measuring antidepressant ‘switching can help scientists and clinicians understand why antidepressants work for some people and not for others www.kcl.ac.uk/news/who-ben...

Our new paper assessing switching between antidepressants as a measure of non-response is now out in BPGOS. Genetic studies show prediction from polygenic scores of remission from clinical studies. Paper: www.sciencedirect.com/science/arti... @kingsioppn.bsky.social Webstory ⬇️

Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics

Selective serotonin reuptake inhibitors (SSRIs) are a first-line pharmacological therapy in major depressive disorder (MDD), but treatment response ra…

sciencedirect.com

Institute of Psychiatry, Psychology & Neuroscience@kingsioppn.bsky.social · last yr.

Who benefits from antidepressants? New research from IoPPN ( @cathrynlewis.bsky.social) and University of Edinburgh shows how measuring antidepressant ‘switching can help scientists and clinicians understand why antidepressants work for some people and not for others www.kcl.ac.uk/news/who-ben...

Congratulations to Lachlan Gilchrist for his successful #PhD viva on Friday. He even admitted to enjoying the discussion! Thanks to examiners @daniellenewby.bsky.social and Golam Khandaker & my @drivehealth.bsky.social co-supervisor @ppetra.bsky.social. @kingsioppn.bsky.social

The SGDP Centre Atrium bookshare captures so much of our work culture. From The Very Hungry Caterpillar to Neuropsychiatry to Jane Austen & Sarah J Maas. Books in English, Chinese, French. Suggested donations supporting local charity. All welcome to donate & borrow, @kingsioppn.bsky.social

#IoPPNFestival Fran Denk @denklab.bsky.social, winner of @kingsioppn.bsky.social Dean’s award for Research Integrity highlighting the importance of statistical understanding and application to support good research practices - honest, rigorous, open, respectful. #statistics rocks!

The #IoPPNResearchFest is here! Join us for rapid-fire talks by IoPPN staff on the latest research in psychiatry, psychology + neuroscience, from the power of belief, neurotrauma and more. Follow us and @thementalelf.bsky.social for highlights and key messages. #AcademiaSky

#BNA2025 Great addition to a conference- a Reading Room - with a view. Thanks to The Queen’s Reading Room for funding and interesting sessions on reading + neuroscience

#BNA2025 Ekta Patel from the Psychiatry Consortium, part of @md-catapult.bsky.social launches our Academia - Industry symposium. Strengthening collaborations through grand challenges, target validation and engagement

Postdoc closing soon - two more days to apply for our statistical genetics role in antidepressant response at @kingsioppn.bsky.social

Cathryn Lewis@cathrynlewis.bsky.social · last yr.

📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social #depression #statistics #genetics #pharmacogenetics #antidepressants my.corehr.com/pls/coreport...

(1/1) 🧠🌎 Just published in Nature Genetics: “Psychiatric genetics in the diverse landscape of Latin American populations” A comprehensive review of progress, challenges, and future directions. 🔗 www.nature.com/articles/s41... #PsychiatricGenetics #GlobalGenomics

📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social #depression #statistics #genetics #pharmacogenetics #antidepressants my.corehr.com/pls/coreport...

Join us for the ISPG Members' Meetup on March 26th! Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline. Don't miss out: us06web.zoom.us/meeting/regi... #ISPG #Genetics #PolygenicScores #Bioinformatics

Paper published: first output from our Wellcome Trust Mental Health Award, AMBER, on how UK Biobank participants report on whether antidepressants helped their depression. tl;dr 75% said SSRI antidepressants helped them feel better ➡️ Paper in Psychological Medicine bit.ly/4ifjcWC 🧵

Three quarters of people who have taken #antidepressants say they helped them "feel better" in new IoPPN research. Read more➡️ www.kcl.ac.uk/news/three-q... #SSRI @wellcometrust.bsky.social @edinburghuni.bsky.social @nihrmaudsleybrc.bsky.social @ukbiobank.bsky.social @kingscollegelondon.bsky.social

The Ripke lab has worked on a new stable release of RICOPILI! Updates include compatibility with GRCh38 and imputation using Minimac4. A software tarball and YAML file are provided to help resolve dependency issues: github.com/Ripkelab/ric... Any feedback is highly welcome! @pgcgenetics.bsky.social

GitHub - Ripkelab/ricopili: Main ricopili repo for public releases

Main ricopili repo for public releases. Contribute to Ripkelab/ricopili development by creating an account on GitHub.

github.com

In 2016, TV reporter James Longman met with IoPPN researchers Profs @cathrynlewis.bsky.social & Roland Zahn on BBC Two to understand how #depression can run in families. His new memoir #TheInheritedMind documents his personal investigation into mental illness. www.theguardian.com/books/2025/f...

The Inherited Mind by James Longman review – a moving memoir of mental illness in the family

The TV reporter’s struggles with depression and the suicide of his father, whose own father killed himself, prompt this incisive, highly personal investigation

theguardian.com

NEW research by IoPPN (@cathrynlewis.bsky.social) and @edinburghuni.bsky.social (Andrew McIntosh) researchers have identified new genetic risk factors for #depression across all global populations for the 1st time, in study in Cell Read more: www.kcl.ac.uk/news/global-...

Global study pinpoints genes for depression across ethnicities

Researchers at King's College London and University of Edinburgh have identified new genetic risk factors for depression across all major global populations for the first time, allowing scientists to predict risk of depression regardless of ethnicity.

kcl.ac.uk

To start 2025 on a cheerful note, the SGDP Centre, @kingsioppn.bsky.social are 'dopamine dressing'. Today - 🟥red, 16th Jan -🟦blue, 23rd Jan - 🟩green, 30th Jan - 🏳️‍🌈any bright colour. Even socks count!

New research (Julian Mutz, Raquel Iniesta, @cathrynlewis.bsky.social) has evaluated AI-based metabolomic 'ageing clocks', which predict health and lifespan using data from blood. It was published in Science Advances, with support of the @nihrmaudsleybrc.bsky.social www.kcl.ac.uk/news/researc...

Researchers compare artificial intelligence 'ageing clocks' to predict health and lifespan

Researchers at the Institute of Psychiatry, Psychology & Neuroscience have conducted a comprehensive study to evaluate artificial intelligence based ageing clocks, which predict health and lifespan us...

kcl.ac.uk