Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...

Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders - Translational Psychiatry

Translational Psychiatry - Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders

nature.com

Sophie Breunig@breunigsophie.bsky.social · 2y ago

New preprint just dropped! 🧬🦠 For this project, we looked at the genetic relationships between psychiatric disorders and immune-mediated diseases. Check out the full paper here: www.medrxiv.org/content/10.1...

Wonderful thread about mentors. @nature.com ‘s mentorship award is open for noms now: www.nature.com/nature/award...

Dr. Kat Napaaqtuk❄️@napaaqtuk.bsky.social · last yr.

Another wonderful reminder of how important mentors are, including informal mentors. The impact that Dr. KK Rao had on Dr. Malik has now spanned a second generation of scientists, including random scientists who only know Dr. Malik through his posts (it me) 🧪

Why do children with Type 1 Diabetes (T1D) often have parents with autoimmune diseases? Our new study shows parental autoimmune conditions affect offspring’s T1D risk through complex genetic factors, including both HLA and non-HLA variants. 🔗 www.cell.com/cell-genomic...

Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms

Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen, Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring T1D. Their creative and r...

cell.com

The Ripke lab has worked on a new stable release of RICOPILI! Updates include compatibility with GRCh38 and imputation using Minimac4. A software tarball and YAML file are provided to help resolve dependency issues: github.com/Ripkelab/ric... Any feedback is highly welcome! @pgcgenetics.bsky.social

GitHub - Ripkelab/ricopili: Main ricopili repo for public releases

Main ricopili repo for public releases. Contribute to Ripkelab/ricopili development by creating an account on GitHub.

github.com

A tour de force review of the connections between between the nervous and immune systems www.nature.com/articles/s41...

Incredibly proud to see our latest work out in Nature Genetics: www.nature.com/articles/s41... Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥 Special thanks to @daniposthu.bsky.social A full thread describing findings below!

Prioritizing effector genes at trait-associated loci using multimodal evidence

Nature Genetics - FLAMES is a machine learning approach combining variant fine-mapping, SNP-to-gene annotations and convergence-based gene prioritization scores to identify candidate effector genes...

rdcu.be

impressive, superhelpful review listing 100s tools for GWAS analysis, with important focus on summary data interpretation biodatamining.biomedcentral.com/articles/10....

The goldmine of GWAS summary statistics: a systematic review of methods and tools - BioData Mining

Genome-wide association studies (GWAS) have revolutionized our understanding of the genetic architecture of complex traits and diseases. GWAS summary statistics have become essential tools for various...

biodatamining.biomedcentral.com

We're hiring a postdoc to help shape our autism research program; please consider applying. www.23andme.com/careers/jobs...

Postdoc - Autism Research – 23andMe Careers

Read about our mission-based culture, look up open positions and check out the perks of working here.

23andme.com

Congrats everyone!!!

Psychiatric Genomics Consortium (PGC)@pgcgenetics.bsky.social · 2y ago

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social. www.cell.com/cell/fulltex... A thread 🧵:

Last work tweet of 2024 (maybe 😉): I, Ken Kendler, Brad Verhulst, @jorsmo.bsky.social and @andrewgrotzinger.bsky.social et al in the Psychiatric Genomics Consortium Cross Disorder Group (PGC-CDG) wrote a review on challenges studying cross disorder (psych) genetics: www.nature.com/articles/s41...

🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.

GitHub - MichelNivard/awesome-complex-trait-genetics: A list of awesome tools for complex trait genetics.

A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics

github.com

Thanks for the valued colleague award @pgcgenetics.bsky.social, which traveled all the way from Singapore to Berlin!

NOW HIRING #postdocjobs NIH funding for a #postdoc with interest in complex genetics / computation / analysis #GWAS #rarevariants #polygenicriskscores in multiple research contexts: psychiatric genomics; cognitive genomics; embryo screening... acnp.org/wp-content/u...