I'm pleased to share our recent paper on how population structure affects our ability to replicate genomic findings across populations, using the 9p21 locus as an example (www.cell.com/ajhg/abstrac....
Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans
Using cross-ancestry fine-mapping across global and local ancestry groups, this study dissects the 9p21.3 coronary artery disease locus and shows how ancestry-specific haplotype structure shapes assoc...
cell.com