Nicholas Mancuso
@nmancuso.bsky.social
Associate Professor at USC. Genetics/Stats/ML. Husband and father. GA➡️CA. He/him. Views are mine. www.mancusolab.com
Are you of mixed European and Asian heritage? Well, you may be able to help us make genetic discoveries that can benefit people from all populations. For that, please join The Australian DNA Bridge, a research study focused on people with mixed ancestry like yours. www.youtube.com/watch?v=Oyr3...
DNA BRIDGE - What's Involved?
YouTube video by HSU Projects
youtube.com
First time at JSM! Any other genetics genomics folks hmu! #jsm2026
stripping OMB of the ability to dole out grants is an enormous win, this nukes the SAVE act, it prohibits further ICE bailouts, adding a "no, really, trump can't break already on-the-books laws regarding elections the federal government doesn't run" clause would be both unnecessary and unproductive
Murshed Zaheed@murshedz.bsky.social · 3d agoPatty Murray and Chuck Schumer decide to strike a “bipartisan” deal with … checks notes … Susan Collins to fund the Trump regime through December which appears to not to any include any safeguards against Trump’s meddling with midterm elections.
Al Pacino's Solidarity Speech
ALT: Al Pacino's Solidarity Speech
static.klipy.com
The Washington Post@washingtonpost.com · 5d agoAmid concerns about the cyclospora parasite outbreak, Taco Bell’s most loyal fans remain undeterred, if slightly nervous. “I eat here almost every day, and I’ve never gotten sick,” one customer said with an empty Luxe Cravings Box in front of him.
this was a hit planned by big burger
Los Angeles Times@latimes.com · 5d agoTaco Bell was crushing it—then cyclosporiasis hit
"People think of this as the ultimate Hollywood experience," says Escott Norton, former executive director of the Los Angeles Historic Theatre Foundation. n.pr/4vVLhIx
LA's legendary Cinerama Dome will reopen, bouncing back from pandemic bankruptcy
"People think of this as the ultimate Hollywood experience," says Escott Norton, former executive director of the Los Angeles Historic Theatre Foundation.
n.pr
More than a month after a fire ripped through an enormous cold-storage warehouse in Los Angeles, residents who live nearby say they have found little respite from the endless stench of rotting food and are anxious about the dangers that may still be lurking in their homes. nyti.ms/4vYe8f2
genoio got bumped to 0.4.0. Most of the changes were refactoring the Rust backend, but the biggest change was to make read_blocks a proper context-managed resource; Previously genoio would open/close/reopen for read_blocks, which is SLOW; It now scans in-place.
ok so, seq2func for gene expression [as we currently stand] makes no sense, right? I'm not crazy I promise.
1/ I believe caQTL effect sizes are quite similar to eQTLs, meaning ~15-100% change in phenotype. Allele-specific effects in heterozygous samples are moderately/strongly correlated with population QTL effects. I suppose this means that peak calling could indeed be affected by variants,
In ATACseq data, if a TF is bound to an accessible region, it can [in theory] be identified using footprint analysis, but do bound TFs meaningfully attenuate called peaks?
AI agent when I return to the office in the morning and see it hit a gate early on
Which One
ALT: Which One
static.klipy.com
*hack wheeze cough cough* but what if, like, the LLMs could also SEE
And then to take all that and try to make one man responsible for all those perceived sins is pretty sickening.
There's far too many people who just completely forget what Jan-March 2020 was like, and what public health officials were dealing with, and are far too certain that there was some perfectly correct call that they failed to make, which then damns them.
King Gizz releasing a 90s hard techno album? I'm surprised but also not surprised?
this is relieving academic.oup.com/mbe/article/...
Robustness of Ancestral Sequence Reconstruction to Among-site and Among-lineage Evolutionary Heterogeneity
Abstract. Ancestral sequence reconstruction is typically performed using homogeneous evolutionary models, which assume that the same substitution propensit
academic.oup.com
🧬New from Tu & Ochoa! 📄Genetic association meta-analysis is susceptible to confounding by between-study cryptic relatedness 👉 bit.ly/3S0jPLF
NEW: In a stunning admission, the Trump administration admitted in court documents that it canceled billions in energy grants to states "based solely" on politics -- and whether that state was represented by Democrats and backed Harris in 2024. www.nytimes.com/2026/07/24/b...
Trump Administration Admits Canceling Grants to States That Did Not Vote for Him
Federal officials said in court documents that they halted billions of dollars in funding for energy projects to states “based solely” on whether they backed President Trump in the 2024 election.
nytimes.com
Giant rats, bright green flies, putrid smells: Unbearable conditions near Boyle Heights warehouse, residents say
Giant rats, bright green flies, putrid smells: Unbearable conditions near Boyle Heights warehouse, residents say
Residents describe the conditions they've been living in nearly a month after a fire damaged a cold storage food warehouse in Boyle Heights.
latimes.com
I mean, if your research isn't immediately translational, why bother? /s I dont know if its the heat, or the stench of millions of pounds of rotting food, but I am angry and finally feel awake
Nicholas Mancuso @nmancuso.bsky.social · 2w agoMy cancellable take is that way fewer MDs should be in leadership positions at Universities.
I was just on my soapbox the other day about how important science journalism is. Now more than ever.
The Open Notebook@theopennotebook.bsky.social · 2w ago“Science journalism is not just about explaining science. It is about showing how science matters for our lives, our decisions, and our shared future, as well as how it's a source of awe and joy,” writes @siricarpenter.bsky.social in our new book’s intro.
My cancellable take is that way fewer MDs should be in leadership positions at Universities.
Important that everyone remembers this lawsuit was brought by faculty association members, not UC. The faculty association had to sue the university to gain access to the DOJ letter.
Jeremy Berg@jeremymberg.bsky.social · 2w ago"The National Institutes of Health admitted to using an internal search tool to flag UC grants that mentioned 'health equity,' 'work force diversity,' 'structural racism,' and 'sexual orientation.' " apnews.com/article/cali... 1/3
are we sure the news about the AI hack isn't just another drummed up press release? did the bot really pursue this on its own, or was it set up in an environment to explicitly search for this and *voila* more press about how good chatgpt is
I demand that codex revert back to reserving '@' for files and '$' for skills. the unisearch/autocomplete suuuuucks for finding local files now