🧪 #Science #ScienceSky #craniosynostosis

FaceBase@facebase.bsky.social · yesterday

Why do some cranial sutures fuse too early? New FaceBase data point to timing: FGFR2 signaling normally declines after birth, dialing down retinoic acid to keep the coronal suture open. Overactivate it and the suture closes. RNA-Seq, Chai lab, USC. @ccmb.usc.edu www.facebase.org/2026/08/04/r...

Thank you, @facebase.bsky.social! 🧪 #Science #ScienceSky

FaceBase@facebase.bsky.social · 5d ago

How do continuously growing teeth withstand constant mechanical load? New FaceBase data identify a KDM6B–BMI1–PIEZO1 "mechanostat" that shields incisor progenitors from stress-induced apoptosis. Bulk RNA-seq + Cut&Run-seq, Chai lab, USC. www.facebase.org/2026/07/30/r...

Congratulations to Chai lab on their paper in @natcomms.nature.com, which notes early indicators of oropharyngeal dysfunction and uncovers the essential role of trigeminal nerve-derived GDF11 signaling in regulating soft palate muscle development. 🧪 #CCMBUSC #ScienceSky #Science #Morphogenesis

Save the date! The 2027 FaceBase Community Forum heads to Los Angeles — April 27–28, 2027, at USC/ISI in Marina del Rey. Details soon: bit.ly/FBForum2027

Professor Yang Chai's lab is hiring a postdoctoral scholar at USC's Center for Craniofacial Molecular Biology! #Science #ScienceJobs #JobsInScience #CareersInScience #Research #ResearchCareers #ScienceSky More information here: usccareers.usc.edu/job/los-ange...

Congratulations to the Chai lab on another great publication in @pnas.org! The study uses tooth root development as a model to investigate how cranial neural crest-derived mesenchyme and its interactions with innervation coordinate organ development. 🧪 #CCMBUSC #Innervation #Science #ScienceSky

Epigenetic regulation of mesenchymal BMP signaling directs postnatal organ innervation | PNAS

Sensory innervation of developing organs is influenced by molecular cues secreted from surrounding tissues, yet the mechanisms coordinating this ti...

pnas.org

Epigenetic “mechanostat” protects tooth progenitor cells from mechanical stress | EurekAlert! www.eurekalert.org/news-release...

Epigenetic “mechanostat” protects tooth progenitor cells from mechanical stress

An epigenetic “mechanostat” has been discovered that protects tooth-forming progenitor cells from mechanical stress and supports lifelong tissue renewal. Using mouse incisors, the study sh...

eurekalert.org

We're looking for some new researchers for our team, including postdocs and lab techs! Please check out the link below for more information on our current available positions. #CCMBUSC #USCResearch #Science #ScienceSky #JobsInResearch #ScienceJobs ccmb.usc.edu/employment-o...

Congratulations to the Chai lab on their latest publication in @brjournal.bsky.social, which identifies KDM6B as an epigenetic regulator that maintains mineralized tissue homeostasis under mechanical stress. 🧪 #CCMBUSC #Science #ScienceSky #Mechanotransduction

KDM6B safeguards mineralized tissue homeostasis from mechanical stress through epigenetic control of PIEZO1-mediated mechanotransduction in the mouse incisor

Bone Research - KDM6B safeguards mineralized tissue homeostasis from mechanical stress through epigenetic control of PIEZO1-mediated mechanotransduction in the mouse incisor

rdcu.be

Congratulations to the Paine lab on their latest publication in Frontiers in Physiology, which introduces a novel Ambn-IRESCre mouse line for studying gene functions during amelogenesis with greater specificity than previous models. 🧪 #CCMBUSC #USCResearch #Amelogenesis #Science #ScienceSky

Frontiers | A novel Ambn-IRESCre mouse line allows ameloblast-specific Smad4 silencing

IntroductionFor more than two decades, enamel researchers have primarily used the keratin-14-Cre (Krt14-Cre) driver line to study ameloblast-specific molecul...

frontiersin.org

USC’s Center for Craniofacial Molecular Biology is hiring a tenure-track Assistant Professor to conduct research in cell & developmental biology, tissue regeneration, cell signaling, cell regulation, & human disease. Learn more using the link below. #USCResearch #ScienceJobs #CareersInScience

Congratulations to the Chai lab on their latest publication in @natcomms.nature.com, which highlights the importance of dural cell migration in maintaining coronal suture patency. 🧪 #CCMBUSC #USCResearch #Craniosynostosis #TGFB

ETS1 Orchestrates a Hybrid EMT Program Driving Metastasis and Immune Evasion 🧪 #CCMBUSC #USCResearch #CancerResearch aacrjournals.org/cancerres/ar...

Zhang and colleagues aim to clarify the role of the canonical BAF (cBAF) chromatin remodeling complex in stem cell fate and niche maintenance using the adult mouse incisor as a model in their latest publication in @natcomms.nature.com. 🧪

Canonical BAF chromatin remodeling complex specifies stem cell fate via cell-type-specific co-factor recruitment - Nature Communications

This study reveals how the cBAF chromatin remodeling complex organizes stem cell environments and guides cell fate decisions by recruiting distinct partner proteins to maintain adult tissue homeostasi...

nature.com

In their latest @natcomms.nature.com publication, Dr. Jian-Fu Chen’s lab identifies synovial lymphatics and defines their role in temporomandibular joint ostreoarthritis (TMJOA) pain. rdcu.be/ffTR8 🧪 #CCMBUSC #TMDs #TMJ

CCMB would like to congratulate Dr. Dechen Lin on his promotion to Associate Professor of Biomedical Sciences at the Herman Ostrow School of Dentistry of USC! #CCMBUSC #USCResearch #Promotion #CancerResearch

🦷 Call for submissions for a special issue of Cells with guest editors Dr. Rucha Arun Bapat and Dr. Marziyeh Aghazadeh! Oral Disease: Cellular Mechanisms and Emerging Therapeutic Strategies For more information: brnw.ch/21x0oZJ

It's almost time for the 18th annual Ostrow Research Day on April 8th in the USC Hotel Ballroom. Please don't forget to register! #CCMBUSC #USCResearch #ResearchDay dentistry.usc.edu/research-day...

New data: Spatial transcriptomics (using seqFISH) reveals a fibroblast-immune microenvironment remodeling pathway in CFA-induced TMJ arthritis in mice. PI: Jian-Fu Chen (University of Southern California) doi.org/10.25550/8Q-...

Ahead of the upcoming #Lymphatics GRC meeting, for #JEM_Spotlight this month I would like to highlight this 2025 study from Jian-Fu Chen @ccmb.usc.edu where his lab identifies lymphatic vessels in the skull periosteum 🧠 Take a look here: doi.org/10.1084/jem....

Dr. Amy Merrill’s lab establishes a new mouse model to better understand the cellular and molecular mechanisms underlying anterior displacement of the articular disc in temporomandibular disorders (TMDs) in their latest publication in JBMR Plus. 🧪 #CCMBUSC #USCResearch #TMDs

New in JBMR® Plus: A reproducible mouse model of TMJ anterior disc displacement — offering a powerful platform to study TMD mechanisms + potential therapeutic targets. Read the open‑access article: doi.org/10.1093/jbmr...

Registration and Call for Abstracts are open for the FaceBase 2026 Community Forum! Advances in data reuse, integration, and AI-ready biomedical research in dental, oral, craniofacial, inner ear and related research. 📅 May 4-5, 2026 📍 Arlington, VA (also via Zoom) Register: bit.ly/FBForum2026

Jianfu Chen's lab uses spatial transcriptomics to map the diverse cell types in the temporomandibular joint (TMJ) and uncover a microenvironment involved in arthritic pain in their latest publication in Advanced Science. 🧪 #CCMBUSC #USCResearch #FightOn #Science #TMJ

CCMB would like to congratulate Dr. Jianfu “Jeff” Chen on his promotion to Professor at the Herman Ostrow School of Dentistry of USC!

Save the dates for the next FaceBase Community Forum: May 4 & 5 2026 in Arlington, VA. More details coming soon! www.facebase.org/community/an...

Missed the FaceBase Bootcamp? No worries! Catch up with recordings and slides covering data discovery, submissions, and DMS plans: 🎥 www.facebase.org/community/tr... #FaceBase #DataSharing #CraniofacialResearch #NIH #DentalResearch #DataReuse #FAIRdata #DataScience

Congratulations to Rucha Bapat and Gayathri Visakan! In addition to being invited to present their research on ameloblastin and enamel formation, they were also awarded Young Investigator Travel Awards at #Enamel11, a conference held in France earlier this month. #CCMBUSC #CraniofacialResearch

📣 Our next virtual bootcamp, tailored for both users and data contributors, is coming up next week: Wednesday, November 5th! Whether you're a seasoned user of FaceBase or looking to contribute data for the first time, this event is for you! www.facebase.org/community/tr...

This week we officially welcomed Dr. Yang Chai as dean of the Herman Ostrow School of Dentistry—renowned scientist, visionary leader, and Trojan through and through.

Yang Chai installed as dean of the Herman Ostrow School of Dentistry of USC

The clinician-scientist is also the school’s associate dean of research and served as interim dean.

today.usc.edu