New pub from @ArcadiaScience 🧵 We found that C. smithii — a freshwater green alga — undergoes wild morphological transformations when grown on Marine Broth. Huge cells with mysterious wisp-like appendages. Here's what we saw. thestacks.org/publications... [1/9]

Morphological transformation of Chlamydomonas smithii grown in Marine Broth medium

Marine Broth induces extreme morphological transformation in C. smithii: Cells shift from typical ellipsoid shape to amorphous forms with thin wisp-like appendages containing mitochondria, revealing u...

thestacks.org

Excited to share some new work from @arcadiascience.com at #CellBio2025! We’re using Chlamydomonas reinhardtii as a rapid in vivo platform to model ADA1 deficiency and test computationally designed therapeutic ADA1 variants. Poster PDF: bit.ly/chlamy-ADA

Discovered some unexpected growth phenotypes in Chlamydomonas flagellar mutants! The cpc1-1 strain (with central pair complex defects) shows surprising metabolic traits that might be independent of its flagellar defects. 🧵 research.arcadiascience.com/pub/observat... [1/9]

Happy Darwin Day! Today, we’re thinking about how to use evolution to accelerate biomedical research. We think the answer is to expand the repertoire of organismal models. Search for the best ones using our new portal, Zoogle: zoogle.arcadiascience.com 🧵

Today at #CellBio24, I'll discuss our new pub at the "Quantitative Biology in Emerging Model Systems" subgroup session at 5:15 pm in Ballroom 20A. Come check it out!

Cameron Dale MacQuarrie@cdmacquarrie.bsky.social · 2y ago

🧵 New from @arcadiascience.bsky.social: We used Chlamydomonas mutants to model specific types of spermatogenic failure and found drugs can rescue swimming behavior in mutation-specific ways. Full pub: research.arcadiascience.com/pub/result-chlamy-spgf [1/8]

Today at #CellBio24, Dave Mets will be at poster B599 talking about mapping genotypes to phenotypes! poster: zenodo.org/records/1449...

Arcadia Science@arcadiascience.com · 2y ago

Come find us at #CellBio24! Our CSO @pracheeac.bsky.social is giving a talk today, and then we've got another talk and a bunch of posters during the rest of the conference. Come say hey!

Our new pub dropped this weekend! For those at #CellBio24, I'll be at poster B73 starting at 11:15 am discussing this work! I'll also be giving a talk on Tuesday at 5:15 pm in Ballroom 20A in the Quantitative Biology in Emerging Model Systems session poster here: zenodo.org/records/14481493

Cameron Dale MacQuarrie@cdmacquarrie.bsky.social · 2y ago

🧵 New from @arcadiascience.bsky.social: We used Chlamydomonas mutants to model specific types of spermatogenic failure and found drugs can rescue swimming behavior in mutation-specific ways. Full pub: research.arcadiascience.com/pub/result-chlamy-spgf [1/8]

🧵 New from @arcadiascience.bsky.social: We used Chlamydomonas mutants to model specific types of spermatogenic failure and found drugs can rescue swimming behavior in mutation-specific ways. Full pub: research.arcadiascience.com/pub/result-chlamy-spgf [1/8]

Rescuing Chlamydomonas motility in mutants modeling spermatogenic failure

We used Chlamydomonas reinhardtii motility mutants with disrupted genes homologous to human SPEF2 or DNALI1 to model spermatogenic failure disorders SPGF43 and SPGF83, respectively. We recovered aspec...

research.arcadiascience.com

Tomorrow at #CellBio24, I'll be at poster (B73) talking about some fun new work we just released using Chlamydomonas to model spermatogenic failure. Check out the poster here: zenodo.org/records/14481493 Join the fun and post your comments & questions on the pub! bit.ly/chlamy-spgf

Arcadia Science@arcadiascience.com · 2y ago

Come find us at #CellBio24! Our CSO @pracheeac.bsky.social is giving a talk today, and then we've got another talk and a bunch of posters during the rest of the conference. Come say hey!

Happening soon at #CellBio24 @ascbiology.bsky.social Ryan York's poster (B574) on a data-driven approach to selecting your model organism @arcadiascience.bsky.social Poster here: zenodo.org/records/14479386 Join the fun & post your comments & questions on the pub! bit.ly/evolutionary...

Leveraging evolution to identify novel organismal models of human biology

Researching just a handful of organisms limits biological discovery. We developed an approach pairing organisms with biological questions to expand research biodiversity.

bit.ly

Arcadia Science@arcadiascience.com · 2y ago

Come find us at #CellBio24! Our CSO @pracheeac.bsky.social is giving a talk today, and then we've got another talk and a bunch of posters during the rest of the conference. Come say hey!

Ryan’s poster: zenodo.org/doi/10.5281/... The concept: research.arcadiascience.com/pub/idea-sel... The approach and analyses: research.arcadiascience.com/pub/result-e... The validation: research.arcadiascience.com/pub/result-c...

If you’re at #CellBio2024 drop by Ryan’s poster today (Board B574) to hear the latest from @arcadiascience.bsky.social about how you can choose the right model system for your research or find areas best studied in the species you have expertise/infrastructure Poster and publications below

Annual reminder that PhyloPic is your free go-to source for organismal silhouettes for #Jack-o'-lantern designs phylopic.org @tmkeesey.bsky.social 🧪

PhyloPic

PhyloPic is an open database of free silhouette images of animals, plants, and other life forms, available for reuse under Creative Commons licenses. Download silhouettes for use in educational materi...

phylopic.org

Two weeks ago we @arcadiascience.bsky.social posted our final, major update to our Chlamydomonas sp. phenotypic variation pub! research.arcadiascience.com/pub/result-c...! A lot of new findings in the 🧵!!! 1/9

Phenotypic differences between interfertile Chlamydomonas species · Genetics: Decoding evolutionary...

We’re crossing C. reinhardtii and C. smithii algae for high-throughput genotype-phenotype mapping. In preparation, we’re comparing the parents to uncover unique species-specific phenotypes.

research.arcadiascience.com

🎉 Excited to share our latest work at #CellBio23! I'll be presenting a poster on our pub “Phenotypic differences between interfertile Chlamydomonas species” and our continued work in the Protists and Parasites Cell Biology poster session (Board #723) @arcadiascience.bsky.social

DALL-E's take on a colored pencil sketch of Chlamydomonas

🚨 @arcadiascience.bsky.social is hiring an Image Analysis scientist!!! 🔬 jobs.lever.co/arcadiascien...

Are you a Chlamydomonas reinhardtii or Chlamydomonas smithii? Find out here!!! www.buzzfeed.com/cameronmacqu... #SpiritAlgae And check out the latest version of our @arcadiascience.bsky.social pub comparing the 2 species! research.arcadiascience.com/pub/result-c... #ArcadiaGenetics

Are You Chlamydomonas Reinhardtii Or Chlamydomonas Smithii?

Which microalgal species are you? Read the pub here: https://research.arcadiascience.com/pub/result-chlamydomonas-phenotypes/

buzzfeed.com

🗣️ Calling all microscopy enthusiasts! We're looking for publicly available, open-source video data featuring bright-field, DIC, or phase-contrast images. These data will complement our own in a new study on focus-filtering techniques. Please comment with a link to a public repository!

New pub update from @arcadiascience.bsky.social! ! We've just released an update to our research on the 2D cell morphology of C. reinhardtii and C. smithii, two interfertile algal species. research.arcadiascience.com/pub/result-c...