Doing proteomics on different yeast biofactories showed us that strains from different origins respond differently to the stress caused by recombinant protein expression—something I had not expected. link.springer.com/article/10.1...

Very excited to share our preprint on BAG6 and RNF126 in cytosolic protein quality control—from BioID to degron mapping. Along with @rhp-lab.bsky.social, we show this pathway plays a major role in targeting misfolded cytosolic proteins for degradation #proteostasis www.biorxiv.org/content/10.6...

📢BMBDG Seminar! Join us November 27, 2025 for an in-person presentation by Dr. El Bachir Affar. 📷 November 27, 2025, 2:30 PM, LSC 3 Hope to see you there!

I survived the 2025 EMBO protein quality control meeting - it was amazing despite a defective projector on day 1, and epileptic crisis on day 2, a black out in day 3, and we all got a shaky wake up call ~6am on day 5 by an earthquake… never a dull moment but most importantly great science

We ran over 200 eggaggregation experiments for Science Rendezvous - a blast!

Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out! meetings.cshl.edu/courses.aspx...

Here’s a quick throwback to celebrate the last day of winter: curling with the lab!

Some of you will recognize this - I am done with our CIHR application. Just in time to start teaching a big course section ✌️

Bioinformatics Job Opportunity Research Associate / Staff Scientist Vancouver Canada Join the Silent Genomes Project to provide an outstanding genetic variation database for Indigenous peoples of Canada to improve rare disease diagnosis tinyurl.com/bm4ptux3 Priority to Canadians Please repost

Research Associate

Academic Job Category Faculty Non Bargaining Job Title Research Associate Department Wasserman Laboratory | Department of Medical Genetics | Faculty of Medicine (Wyeth Wasserman) Posting End Date Febr...

tinyurl.com

Job available for Full Professor Tier 1 Canada Research Chair (CRC) - Indigenous Health and Well-Being at the Faculty of Health Science, Simon Fraser University (RT 🙏🏼 please): www.sfu.ca/vpacademic/a...

Canada Research Chair - Indigenous Health and Well-Being

sfu.ca

I enjoyed both @cherisirois.bsky.social presentation and conversation about the publishing world and Cell Press today

With the help of e@UBC our BMB and MSL postdocs organized this great 1/2 day Academia to Industry workshop with a focus on entrepreneurship today

Even though David Baker's presentation was online, it was rad and inspiring. I really enjoyed today's session on machine learning at the 2025 PepTalk & BioLogic Summit

Calling early-career colleagues with stories of racism / sexism / microaggressions to share (anonymously or not) for an article someone I know is doing! Please send me a DM asap. They'd need to interview you tomorrow (Tues). It's important these stories are shared, so please do reach out!

Protein quality control is a tug-of-war between degradation machinery and chaperones that promote folding. Thrilled to see our latest manuscript is now published! 👇 Follow 🧵 for quick summary journals.biologists.com/jcs/article-...

CONGRATS to @supportourscience.bsky.social, Dr. Kaitlin Kharas, @sarahlaframboise.bsky.social & @cdrobich.bsky.social who were named "Nature's 10", a list of people who shaped science in 2024. #SupportOurScience achieved amazing things. The advocacy continues! www.nature.com/articles/d41...

This PhD student helped to win a major pay hike for Canadian researchers

Kaitlin Kharas is part of Nature’s 10, a list of people who shaped science in 2024.

nature.com

ICYMI: Finland downgrades a bunch of Frontiers and MDPI journals to level 0. julkaisufoorumi.fi/en/news/chan...

Changes to the classification

julkaisufoorumi.fi

Failures in Science - I just received a negative decision on a grant proposal—my fifth in a row. It’s a though streak but not the first one, and I just wanted to share. short 🧵👇

Will U.S. government scientists soon face the “muzzling” their Canadian counterparts experienced under right-wing Prime Minister Stephen Harper? David Shiffman spoke to several people whose work was affected by Harper’s regressive policies, and they have advice to help prepare for Trump 2.0. ⬇️

Advice for U.S. Government Scientists: Lessons Learned From the ‘Muzzling’ of Their Canadian Counterparts • The Revelator

The next four years will be awful for the science and conservation community. By learning from past experiences, we can minimize the damage.

therevelator.org

ubc.wd10.myworkdayjobs.com/en-US/ubcfac... We are looking for an imaging master to run a very cool shared microscope - Raman label-free, 2-photon, FLIM, high-res, fast capture, thick live tissue, organoids, high-content screening. We are a dynamic and supportive and fun environment.

Research Associate

Academic Job Category Faculty Non Bargaining Job Title Research Associate Department Johnson Laboratory | Department of Cellular and Physiological Sciences | Faculty of Medicine (James Johnson) Postin...

ubc.wd10.myworkdayjobs.com

Earlier this year, I received news that fake peer reviews were allegedly being submitted impersonating me and approximately six others I shared my story with Science to, hopefully, reduce the chance of this kind of breach happening again www.science.org/content/arti...

‘It felt very icky’: This scientist’s name was used to write fake peer reviews

Elsevier retracts dozens of journal articles that were published based on “fictitious” reviews

science.org

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI. www.biorxiv.org/content/10.1...

Congrats to Dane Sands in our lab for his Zymeworks Fellowships Award in Advanced Protein Therapeutics

Great quick read and a reminder that we first need to admit and accept our ignorance—that's what makes science so fun!

Science News@scinews.bsky.social · 2y ago

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 1. The importance of stupidity in scientific research Open Access journals.biologists.com/jcs/article/...

SAVE THE DATE 🗓️Ubiquitin & Friends Symposium: 8-9 May 2025 in Vienna! Registration will open🔜 Keep an eye out for the announcement 👀 ✨guest speaker lineup👇🧵 +talks from abstracts! Great chance for #ECRs to meet with peers & experts in a friendly setting! 🔗 www.protein-degradation.org/symposium/

This is real cool study showing how ubiquitin can recruit and activate a protease to eliminate a (DNA cross linked) protein … independently of the proteasome

bioRxiv Biochemistry@biorxiv-biochem.bsky.social · 2y ago

Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability https://www.biorxiv.org/content/10.1101/2024.11.26.625192v1

🚀 Excited to announce that our Lab @UBC is recruiting! 🌟 We're looking for passionate intern, graduate, and postdoc with strong coding/ML backgrounds to join us in advancing AI for single-cell biology & brain-computer interfaces. 🏔️ Vancouver awaits! 👉 tanglab.msl.ubc.ca 📧 xin.tang@msl.ubc.ca

I love CAT tails (how cool is to have an RNA-independent pathway to synthesize polypeptides at the ribosome). Check out our preview article on a recent study from the Young-Jun Choe's lab written by @shriyakamat.bsky.social www.cell.com/molecular-ce...

Lost in translation: Threonine dictates aggregation of CAT tails

In this issue of Molecular Cell, Chang et al. elaborate on the mechanisms by which CAT tail aggregation is mediated through threonine residues and how it contributes to the perturbation of proteostasi...

cell.com

agree!! I can only remember 1/2 of the acronyms on a good day, so when a sentence uses several of them, it simply become too cryptic I use a bold font each time I introduce an acronym to help distracted readers

Patrick Moynihan@pmoyniha.bsky.social · 2y ago

I am begging people to use fewer acronyms (ideally zero) in their grant/fellowship etc apps. As a panelist if I am even slightly off your subject area it makes it really challenging to parse.

I read that article last spring and I highly recommend it - even for non NIH applications!!!

Hesso Farhan@hessofarhan.bsky.social · 2y ago

This is an interesting an helpful read: Elements of successful NIH grant applications www.pnas.org/doi/10.1073/...