Micha Rapé Lab
@micharapelab.bsky.social
Professor and Head of the Division of Molecular Therapeutics in MCB, UC Berkeley Founder, Nurix and Lyterian Therapeutics Excited about stress responses, ubiquitin, proteasome, targeted protein degradation, drug discovery
Congratulations to Ross Wilson in our Molecular Therapeutics Division in MCB at @ucberkeleyofficial.bsky.social for delivering his promotion talk! Ross is developing new CRISPR delivery methods, spearheading our hands-on therapeutics discovery lab for undergrads, and founding Editpep!
Hi all, great @keystonesymposia.bsky.social meeting on Ubiquitin coming up. Poster deadline fast approaching (2/2). Held at some place (Banff!!) and time as Induced Proximity meeting. Hope to see you there!
Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social www.sciencedirect.com/science/arti...
Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12
Centered on the transcription factor NRF2 and its E3 ligase CUL3KEAP1, the oxidative stress response protects cells from damage by reactive oxygen spe…
sciencedirect.com
Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉 aprecruit.berkeley.edu/JPF05098
Excited about turning basic science into new therapeutic modalities? Want to work with brilliant and *friendly* colleagues? Hoping to be part of a public university that shapes California? Then come join us #MolecularTherapeutics, @ucberkeleyofficial.bsky.social !!! aprecruit.berkeley.edu/JPF05098
Assistant Professor -Molecular Therapeutics - Molecular and Cell Biology
University of California, Berkeley is hiring. Apply now!
aprecruit.berkeley.edu
Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...
“Revolutionary Science Comes from Unexpected Angles”
magazine.hms.harvard.edu
UC Berkeley isn’t just the No. 1 public research university in the nation — it’s a force for the public good. youtu.be/z0MokpvFauc?...
UC Berkeley research builds a better tomorrow
YouTube video by UC Berkeley
youtu.be
Congrats to MCB postdocs Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab) for being selected as 2025 Jane Coffin Childs Fellows! 🎉👏 @jcchildsfund.bsky.social @nogaleslab.bsky.social @micharapelab.bsky.social www.jccfund.org/fellows/clas...
Many congratulations to Heegwang Roh for being selected as a Jane Coffin Childs postdoctoral fellow! Go Heegwang! www.jccfund.org/wp-content/u...
jccfund.org
Thank you to Sara Osman for highlighting our recent SIFI work! www.nature.com/articles/s41...
Better SIFI than sorry - Nature Structural & Molecular Biology
Nature Structural & Molecular Biology - Better SIFI than sorry
nature.com
Very excited about these unique opportunities - for advancing groundbreaking science and for our students to advance their careers - at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social
Molecular Therapeutics Initiative@mti-ucb.bsky.social · last yr.Excited to announce a new collaboration between the Molecular Therapeutics Initiative (MTI) and Amgen Inc.! This partnership includes funding for cutting-edge research & an internship program for grad students to train in drug discovery & development at Amgen. #MTI #Amgen #Biotech #UCB
Congratulations James! From basic discovery to drugging it in such a short time! Amazing work out of #MolecularTherapeutics @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social!!!
James Olzmann@olzmannlab.bsky.social · last yr.Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Skytorial! 1/9
Congratulations to our grad students Rachael McMinimy and Chris Padovani, who yesterday received their degrees from @ucberkeleyofficial.bsky.social! Thank you for everything, and we will miss you!
Thank you to Michael Ward for presenting his amazing science addressing urgent problems in neurodegenerative disease at a joint #MolecularTherapeutics, @mti-ucb.bsky.social, and Neuroscience talk at @ucberkeleyofficial.bsky.social today! Great science helping patients is more important than ever!
Congratulations to #MolecularTherapeutics faculty and @mti-ucb.bsky.social member @olzmannlab.bsky.social for receiving the Beatriz Manz award for 'transformational teaching and community service'. Glad to have you as a friend and colleague @ucberkeleyofficial.bsky.social, James!
🌍 Meet Dr. Matt Welch, 2025 MTI Innovator Awardee! His lab is developing selective inhibitors of parasite-specific kinesins - a new and safer strategy to treat African sleeping sickness and related diseases. A leap forward in neglected tropical disease drug discovery. #MTI #GlobalHealth
Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus! www.nature.com/articles/s41...
Molecular basis of SIFI activity in the integrated stress response - Nature
Nature - Molecular basis of SIFI activity in the integrated stress response
nature.com
🧠 Meet Dr. Ehud Isacoff, 2025 MTI Innovator Awardee! His lab is using FRET-based biosensors to find compounds that fine-tune glutamate receptors - unlocking new treatments for depression, including hard-to-treat cases. A new era of brain-targeted molecular therapeutics. #MTI #Neurobiology #FRET
Thank you to @brentstockwell.bsky.social of @columbiauniversity.bsky.social for visiting #MolecularTherapeutics at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social and presenting a tour-de-force through the ferroptosis field!
Congratulations to #MolecularTherapeutics faculty and @mti-ucb.bsky.social member Markita Landry on winning a Guggenheim Fellowship! So cool to work with such amazing colleagues on a daily basis! news.berkeley.edu/2025/04/22/t...
Two Berkeley professors receive prestigious Guggenheim fellowships - Berkeley News
Philosopher Hannah Ginsborg will use the award to write a book about the relation between norms and reasons, while chemical engineer Markita del Carpio Landry will try to find molecules in little-stud...
news.berkeley.edu
Wonderful talk by @rushika-perera.bsky.social of @ucsfhealth.bsky.social today in our @mti-ucb.bsky.social/#MolecularTherapeutics seminar series at @ucberkeleyofficial.bsky.social today, presenting cool data about organ-selective metastasis! Thank you!!!
New paper from @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social faculty member @robzonculab.bsky.social ! Congratulations!!!
The EMBO Journal@embojournal.org · last yr.AKAP11 recruits PKA holoenzymes to #autophagosomes in a bidirectional functional association, both promoting downstream PKA signaling and increasing AKAP11-PKA complex degradation @robzonculab.bsky.social @ucberkeleyofficial.bsky.social www.embopress.org/doi/full/10....
Congratulations to Mangyu and Denis! @ucberkeleyofficial.bsky.social
Cell Chemical Biology@cp-cellchembiol.bsky.social · last yr.Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction by Mangyu Choe, Denis V. Titov et al at @ucberkeleyofficial.bsky.social http://dlvr.it/TKF1S6
Huge thank you to Leon Chen of The Column Group, who taught our #MolecularTherapeutics grad students the ins-and-outs of biotech today! 🙏
One of the best things about teaching (and doing research) at @ucberkeleyofficial.bsky.social is our environment. Huge thanks to Arnav Metha of The Column Group, who taught our #MolecularTherapeutics grad students the ins-and-outs of clinical trials!
Thank you to Spark NS for helping us turn the ubiquitin system against Parkinson's Disease! Kudos to @ucberkeleyofficial.bsky.social student Srividya Chandrasekhar and postdoc Josh Sheetz for their groundbreaking work! sparkns.org/programs/pro...
Projects
sparkns.org
Amazing story from #MolecularTherapeutics faculty @robzonculab.bsky.social with lead author @aakritijain.bsky.social describing membrane protein degradation in the lysosome. Congratulations!! www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
science.org
If you are immigrant into the US and work in the biomedical sciences (like me) and are still young (not like me), please apply for the Vilcek prizes for Creative Promise founded by an inspiring immigrant couple, Marica and Jan Vilcek. vilcek.org/prizes/vilce...
Vilcek Prizes for Creative Promise - Vilcek Foundation
The Creative Promise Prizes are awarded to young immigrant professionals who have demonstrated outstanding achievement early in their careers.
vilcek.org
Thank you to Christina Woo for presenting such a data-packed, standing-room only seminar in Molecular Therapeutics @ucberkeleyofficial.bsky.social this week! Awesome work!!!
