Francesca Ceroni
@ceronifranci.bsky.social
Senior Lecturer @ Chemical Engineering Department, Imperial College London (views are my own)
Join us Apr. 16 UCL! Removing Host-Induced Bias in Directed Evolution with Cell-Free Ultra-High Throughput Screening Platform Lise Boursinhac (Cambridge) Deciphering Human Gene Biochemistry at Scale Using Synthetic, Homology-Free DNA Josh Mayne (UCL, Imperial) events.humanitix.com/copy-of-lond...
London SynBio Network 15
London SynBio afterwork talks and networking event on Thursday 16th of April
events.humanitix.com
So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli? Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv: doi.org/10.64898/202...
Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation
Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...
doi.org
Do you want to engineer mammalian protein secretion? We present STAMPS: signal-peptide transformer for tuning mammalian protein secretion! Led by Jacopo in the lab, in collaboration with Cleo Kontoravdi and colleagues at Astra Zeneca, STAMPS is now on Bioarxiv! www.biorxiv.org/content/10.1...
STAMPS: Signal-peptide Transformer for Augmenting Mammalian Protein Secretion
While secretion plays a key role in the diverse applications of cell engineering, to date only a handful of mammalian signal peptides have been characterised in depth and systematic efforts to build n...
biorxiv.org
'Transgene integration in mammalian cells' led by John Fong from the group, is out now! Check it at www.sciencedirect.com/science/arti... Thanks @cp-cellsystems.bsky.social for the opportunity!
Transgene integration in mammalian cells: The tools, the challenges, and the future
Robust and stable expression of genes of interest is crucial for studying and engineering biology. While expressing desired gene products in some micr…
sciencedirect.com
PhD positions available in our group! Please share! www.findaphd.com/phds/project...
PhD Scholarship project: Engineering biology approaches to mammalian cells at Imperial College London on FindAPhD.com
PhD Project - PhD Scholarship project: Engineering biology approaches to mammalian cells at Imperial College London, listed on FindAPhD.com
findaphd.com
Just out: 'Aptamer-based burden biosensors' led by Alice in the lab. Funded by NSF-BBSRC in collaboration with @francolab.bsky.social, we show aptamers cause burden in E.coli. We then develop a burden biosensor for identification of low-burden genetic variants: www.sciencedirect.com/science/arti...
Design of an intracellular aptamer-based fluorescent biosensor to track burden in Escherichia coli
Cell burden impacts the performance of engineered genetic constructs with great interest towards the development of tools to track it and improve biot…
sciencedirect.com
Tom Ellis@proftomellis.bsky.social · last yr.Annalise Zouein's main PhD research paper is published today in Trends in Biotech. Building and using repetitive transcription factor-binding arrays to modulate gene regulation in mammalian cells. No RNA, no protein - just DNA doing the work! www.sciencedirect.com/science/arti...
We're hiring for 2 postdocs to work in our lab in London on the newly announced Wellcome Trust SynHG project. If you know people looking to work on big-scale ambitious science like this, please RT and share this with them. Apply by 7/20, interviews in Aug. imperial.ac.uk/jobs/search-...
Annalise Zouein's main PhD research paper is published today in Trends in Biotech. Building and using repetitive transcription factor-binding arrays to modulate gene regulation in mammalian cells. No RNA, no protein - just DNA doing the work! www.sciencedirect.com/science/arti...
Thrilled I am going to be speaking at the Royal Society Theo Murphy Workshop on Generative Biology next October! royalsociety.org/science-even...
Generative biology: new approaches to study developmental design principles | Royal Society
Theo Murphy meeting organised by Mr Jake Cornwall-Scoones, Dr Dirk Benzinger, and Professor Sally Lowell.
royalsociety.org
A huge, new resource for plasmid research - PlasmidScope is a database of 852,000 #plasmid sequences with a rich set of annotations, automated online analysis and interactive visualisation academic.oup.com/nar/article/...
PlasmidScope: a comprehensive plasmid database with rich annotations and online analytical tools
Abstract. Plasmids are extrachromosomal genetic molecules that replicate independent of chromosomes in bacteria, archaea, and eukaryotic organisms. They co
academic.oup.com
www.nature.com/articles/s41...
Degradation bottlenecks and resource competition in transiently and stably engineered mammalian cells - Nature Communications
Resource competition leads to coupling of co-expressed heterologous genes in mammalian cell lines. Here, the authors highlight the effect of competition for protein degradation on gene expression of t...
nature.com
Rearranging mammalian genomes with recombinases to study structural variants at scale provides insights into genome organization and dispensability #NBTHighlight www.science.org/doi/10.1126/... and www.science.org/doi/10.1126/...
Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
science.org
Our work on 'Degradation bottlenecks in mammalian cells' is now out @NatureComms: www.nature.com/articles/s41... Well done to the whole team! You can read this at rdcu.be/d5o2h Happy 2025 everyone!
nature.com
Check out our latest pre-print where we used our ASP-#SPARK #sensor to unveil #SnRK1's multifaceted role during #plant growth and #development! bit.ly/49JVZrY Including real-time #spatiotemporal visualization of SnRK1 activity in a growing #Arabidopsis root! 😀
Latest preprint from Jane (Xinyu Lu) in our group explores what happens when we build a synthetic genome cluster in yeast for Histidine biosynthesis and SCRaMbLE it to see whether selected-for gene rearrangements can guide better design.
bioRxiv Synthetic Biology@biorxiv-synthbio.bsky.social · 2y agoIterative SCRaMbLE for Engineering Synthetic Genome Modules and Chromosomes https://www.biorxiv.org/content/10.1101/2024.12.06.627136v1
Still time to apply, please share and spread the opportunity!
Francesca Ceroni@ceronifranci.bsky.social · 2y agoExciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg. Come and join us at @ImperialChemEng! Apply at the link below: www.imperial.ac.uk/jobs/search-...
Great to have @ciaranlkelly.bsky.social presenting the exciting work his group is doing here at Imperial!
Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg. Come and join us at @ImperialChemEng! Apply at the link below: www.imperial.ac.uk/jobs/search-...
