Nature Biotechnology
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Publishing the best of biotech science and business. Find us on Twitter, Facebook & Instagram. Part of @natureportfolio.nature.com.
A multi-institute, multi-platform initiative generates standard metrics and best practices for spatial transcriptomics analysis go.nature.com/4rBC1Z0 rdcu.be/fxFoM
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets - Nature Biotechnology
A multi-institute, multi-platform initiative generates standard metrics and best practices for spatial transcriptomics analysis.
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Hybrid quantum–classical computer systems act as a bridge to achieving quantum advantage, but they are not likely to scale well to the number of qubits required for use cases that are projected to eventually benefit most from quantum computing www.nature.com/articles/s41...
As biotech evolves to shape economic strength, national resilience and geopolitical influence, the industry must commit to rebuilding and preserving public trust in the face of growing pressures on the institutions that underpin scientific leadership www.nature.com/articles/s41... rdcu.be/fxOKG
A resource of human RNA-protein associations is produced using a sequencing-based method go.nature.com/4gmf1Ii rdcu.be/fxFn1
Genome-wide mapping of RNA-protein associations through sequencing - Nature Biotechnology
A resource of human RNA-protein associations is produced using a sequencing-based method.
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Each year, we highlight companies that received sizeable early-stage funding in the previous year. Excelsior Sciences is developing a closed-loop system for drug discovery using carbon building bloccs www.nature.com/articles/s41...
Editor’s pick: Excelsior Sciences - Nature Biotechnology
Each year, Nature Biotechnology highlights companies that received sizeable early-stage funding in the previous year. Excelsior Sciences is developing a closed-loop system for drug discovery using car...
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Evolution of botulinum neurotoxin serotype X proteases to induce inflammatory cell death in cancer cells - @broadinstitute.org @hhmi-science.bsky.social www.nature.com/articles/s41...
Evolution of botulinum neurotoxin serotype X proteases to induce inflammatory cell death in cancer cells - Nature Biotechnology
Directed evolution of proteases induces targeted, multipathway lytic cell death in cancer cells.
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Just out in @natbiotech.nature.com! PKS-engineered route to chiral monomers for PDKs: tunable Tg and programmable depolymerization, all from corn stover. Cheaper & lower-GHG than dimedone. Biosynthesis meets circular plastics. @molecularfoundry.lbl.gov @jbei.lbl.gov www.nature.com/articles/s41...
Engineered polyketide synthases enable a microbial chassis for recyclable plastics with tunable properties - Nature Biotechnology
Polyketide synthases are engineered for the production of sustainable plastics.
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The new laws break away from 20-year-old restrictive GMO directives to give an official nod to plants made with new genomic techniques www.nature.com/articles/s41...
EU relaxes rules for gene-edited crops - Nature Biotechnology
The new laws break away from 20-year-old restrictive GMO directives to give an official nod to plants made with new genomic techniques.
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Research Highlight: An RNA-guided ‘chromatin shredder’ for selective cell killing www.nature.com/articles/s41...
An RNA-guided ‘chromatin shredder’ for selective cell killing - Nature Biotechnology
Nature Biotechnology - An RNA-guided ‘chromatin shredder’ for selective cell killing
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Doudna Lab@doudna-lab.bsky.social · 2mo agoWe now present our latest work, now out in @nature.com! A creative new CRISPR-based approach can selectively destroy cells carrying undruggable mutations in cancer. Work led by @jingkunzeng.bsky.social In collaboration with Alan Ashworth, Yang Liu and Ryan Jackson. www.nature.com/articles/s41...
Recent moves of note in and around the biotech and pharma industries www.nature.com/articles/s41... rdcu.be/fw6w6
People - Nature Biotechnology
Recent moves of note in and around the biotech and pharma industries.
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Append editing of ADP-ribosyl to thymine is used for precise modifications in bacteria and eukaryotes go.nature.com/4n7zDpG rdcu.be/fwxAh
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - Nature Biotechnology
Append editing of ADP-ribosyl to thymine is used for precise modifications in bacteria and eukaryotes.
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Biotech news from around the world: South Africa, India, Philippines, Uganda www.nature.com/articles/s41... rdcu.be/fwVOO
Biotech news from around the world - Nature Biotechnology
Nature Biotechnology - Biotech news from around the world
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Ten commitments for a bold biotechnology industry - @jeremymax.bsky.social www.nature.com/articles/s41...
Diverse stakeholders were surveyed to characterize three key factors influencing healthcare innovation, including the role of institutional players, projected areas of development and persistent barriers to implementation www.nature.com/articles/s41... rdcu.be/fwI8K
Recent patents relating to bispecific antibody compositions and methods of use www.nature.com/articles/s41... rdcu.be/fwItG
Bispecific antibodies - Nature Biotechnology
Recent patents relating to bispecific antibody compositions and methods of use.
nature.com
Property guidance for protein sequence generative models with ProteinGuide - @jlistgarten.bsky.social @savagecatsonly.bsky.social www.nature.com/articles/s41...
Property guidance for protein sequence generative models with ProteinGuide - Nature Biotechnology
On-the-fly conditioning of pretrained protein generative models guides protein generation toward specific properties.
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An AI-enabled structural atlas decodes kinase specificity across the human proteome - @harvardcellbio.bsky.social @danafarber.bsky.social www.nature.com/articles/s41...
An AI-enabled structural atlas decodes kinase specificity across the human proteome - Nature Biotechnology
Phosphorylation potential and kinase specificity are assigned for the entire human proteome.
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Skin metagenomic and metatranscriptomic analysis shows divergence between microbial abundance and activity go.nature.com/4fVg95j rdcu.be/fwxuI
Skin metatranscriptomics reveals a landscape of variation in microbial activity and gene expression across the human body - Nature Biotechnology
Skin metagenomic and metatranscriptomic analysis shows divergence between microbial abundance and activity.
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Molecular and technical considerations for developing mechanistically grounded virtual immune cell models www.nature.com/articles/s41... rdcu.be/fwwlC
Toward mechanistic virtual immune cells - Nature Biotechnology
This Comment outlines molecular and technical considerations for developing mechanistically grounded virtual immune cell models.
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In Brief: @mhragovuk.bsky.social proposes Rare Disease Therapies Regulatory Framework, an ambitious new pathway for regulating therapies that treat diseases too rare to be considered commercially viable www.nature.com/articles/s41... rdcu.be/fwwhM
MHRA’s radical rare disease proposal - Nature Biotechnology
Nature Biotechnology - MHRA’s radical rare disease proposal
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Engineered polyketide synthases enable a microbial chassis for recyclable plastics with tunable properties - @keaslinglab.bsky.social @jbei.lbl.gov @ucberkeleyofficial.bsky.social www.nature.com/articles/s41...
Engineered polyketide synthases enable a microbial chassis for recyclable plastics with tunable properties - Nature Biotechnology
Polyketide synthases are engineered for the production of sustainable plastics.
nature.com
New online in @natbiotech.nature.com: Spatial relationships between neoantigens and cognate T cells are studied.
Nature Biotechnology@natbiotech.nature.com · 2w agoSingle-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells - @danafarber.bsky.social @harvardmed.bsky.social @broadinstitute.org www.nature.com/articles/s41...
Check out the brief digital edition of @natbiotech.nature.com July issue here: mp.weixin.qq.com/s/mYgJDrWKRL...
Nature Biotechnology七月刊内容预览
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Nature Biotechnology@natbiotech.nature.com · 3w agoThe July issue is live nature.com/nbt/volumes/... On the cover, @ycongzhang.bsky.social @efranzosa.bsky.social @hutlab.bsky.social introduce FUGAsseM, a method that uses microbial community data to infer the functions of previously uncharacterized gene products go.nature.com/435C4lp rdcu.be/ftNUV
From virtual patients to simulated cells and organs-on-chips, digital twins are forecasting disease and guiding drug development. Scientists now must figure out how to define, validate and deploy these models www.nature.com/articles/s41... [🔓read free with login]
Biotech’s digital twin dilemma - Nature Biotechnology
From virtual patients to simulated cells and organs-on-chips, digital twins are forecasting disease and guiding drug development. Scientists now must figure out how to define, validate and deploy thes...
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An open-source platform for data-independent acquisition proteomics adapts predicted libraries to experimental settings go.nature.com/4qmEQMM rdcu.be/fvytw
AlphaDIA enables DIA transfer learning for feature-free proteomics - Nature Biotechnology
An open-source platform for data-independent acquisition proteomics adapts predicted libraries to experimental settings.
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Biotech is back. But continued investor caution, the rise of China and fast-moving AI are changing the sector’s contours www.nature.com/articles/s41... [🔓read free with login]
Biotech’s coming of age - Nature Biotechnology
Biotech is back. But continued investor caution, the rise of China and fast-moving AI are changing the sector’s contours.
nature.com
Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells - @danafarber.bsky.social @harvardmed.bsky.social @broadinstitute.org www.nature.com/articles/s41...
Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells - Nature Biotechnology
Spatial relationships between tumor neoantigens and cognate T cells are studied.
nature.com
AI model using AlphaFold3-predicted contact probabilities maps and reduces genome editor off-targets, enabling highly precise DNA base editing with improved specificity. #NBThighlight www.nature.com/articles/s41...
Precise DNA base editing using AlphaFold3-based contact modelling - Nature
ContactSeek is an AlphaFold3-driven model that can improve the precision of genome-editing tools.
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