Christopher Frøhlich
@cfr016.bsky.social
Enzyme evolutionist at UiT- The Arctic University of Norwary
very cool. old questions, new methods = nuanced view of evolutionary landscape of selection, chance, and contingency elifesciences.org/articles/103...
The adaptive landscapes of three global Escherichia coli transcriptional regulators
Across three global Escherichia coli regulators, identical starting sequences can evolve toward many distinct strong-binding peaks, with chance, historical contingency, and evolutionary bias shaping w...
elifesciences.org
🧬 I'm looking for a Researcher (2 years) in Molecular Biology and Antimicrobial Resistance at UiT The ❄️Arctic University of Norway (Tromsø). 🔬 If you have experience building and screening enzyme libraries and characterising the variants that come out, get in touch.
🦠 #Collateralsensitivity, when resistance to one antibiotic creates vulnerability to another, offers a route to fight #AMR. We followed the evolution of #β-lactamase OXA-48 and show mutations can both create AND mitigate these trade-offs. 💊 doi.org/10.1016/j.jm...
Redirecting
doi.org
We studied the causes of #collateralsensitivity from a single enzyme perspective using and how stable such #tradeoffs are during #coselection. In short, resistance evolution can cause strong but migigatable trade-offs. Preproof is now available on @JMB: www.sciencedirect.com/science/arti...
Mechanistic origins and evolutionary erosion of collateral sensitivity in a β-lactamase
As antibiotic discovery stalls, exploiting collateral sensitivity, where resistance to one drug increases sensitivity to another, offers a promising r…
sciencedirect.com
Looking for a PostDoc in molecular biology and structural biology ? Check out the position in my group: www.jobbnorge.no/en/available...
Postdoctoral Research Fellow at the Department of Medical Biology (296377) | UiT The Arctic University of Norway
Job title: Postdoctoral Research Fellow at the Department of Medical Biology (296377), Employer: UiT The Arctic University of Norway, Deadline: Thursday, March 26, 2026
jobbnorge.no
Sometimes, adaptation to one #antibiotics can make bacteria more vulnerable to other drugs. #CollateralSensitivity. 💡 By following the evolution of a β-lactamase, we uncovered how mutations can both create and mitigate such collateral sensitivity networks. www.biorxiv.org/content/10.6...
biorxiv.org
🚨PREPRINT🚨 Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬. #OXA-48 #ceftazidime #enzymeevolution www.biorxiv.org/content/10.6...
Evolution tunes functional sub-state interconversion to boost enzyme function
Enzymes do not operate as static structures, but continuously fluctuate between different conformations. Enzymes therefore dynamically sample conformations with varying catalytic activity. However, it...
biorxiv.org
Living in the Arctic 🥶 means Christmas comes early 🎁🥳 10 MNOK (≈1 MUSD) Early Career Investigator grant from the Research Council of Norway to work with the fabulous @bunzela.bsky.social (Max Planck Institute) on uncovering the molecular mechanisms of antibiotic resistance. #AMR #beta-lactamases
Interested in #β-lactamase inhibitors? 🧪 Our new #mSphere paper shows how a covalent boronic-acid + chelator fusion ⚗️ can restore β-lactam susceptibility in metallo-β-lactamase producers, even in variants that are difficult to inhibit with #taniborbactam. journals.asm.org/doi/full/10....
APC24-7, a covalent combination of boronic acid and chelator moieties, restores β-lactam efficiency against metallo-β-lactamase-producers | mSphere
The ability of bacteria such as Klebsiella pneumoniae and Escherichia coli to circumvent antimicrobial chemotherapy has become a global public health crisis. The high prevalence of β-lactamase enzymes...
journals.asm.org
Is it too early for a year review? 🤔 Research stays at ETH Zürich with Adrian Bunzel and at UBC Vancouver with Nobu 🤓. Now I’m moving labs to start as Associate Professor at UiT, which means organising freezer contents 📦. Two β-lactamase evolution preprints coming soon 🧬. Stay tuned!
🔄 #Enzymes can adopt multiple #conformations. ⚡ Some of these act as functional sub-states. 📚 We summarised recent studies, the methods used to uncover these hidden states, and the challenges ahead in linking them to #proteinevolution. www.sciencedirect.com/science/arti...
Functional sub-states link conformational landscapes and protein evolution
The intrinsic conformational flexibility of proteins creates structural heterogeneity, giving rise to conformational ensembles within the energy lands…
sciencedirect.com
I highly recommend this conference, i thoroughly enjoyed the 2022 meeting 👇🏻
Microbiology Society@microbiologysociety.org · last yr.The abstract submission deadline for Understanding and predicting microbial evolutionary dynamics 2025 is soon approaching! Make sure to submit by 23:59 BST on 7 July 2025. microb.io/Abstracts #MicroEvo25
#JournalClub 🚨 Out Now! A short read describing a xanthone-derived antibiotic which has multifaceted mode of action. #MicroSky #AMR www.nature.com/articles/s41...
A xanthone-derived antibiotic with a multifaceted mode of action - Nature Microbiology
Nature Microbiology - A xanthone-derived antibiotic with a multifaceted mode of action
nature.com
🔬 Join us! We are hiring three PhD students to advance enzyme design and develop photoenzymes for carbon capture and nitrogen fixation. If you are passionate about protein engineering, computational modeling, or synthetic biology, check out the job openings! 📌 www.mpg.de/24336572/phd...
Three PhD positions | Computational protein design
Three PhD postiions in computational protein design
mpg.de
🔬 PhD in Antibiotic Resistance Evolution – Join Us in the Arctic! ❄️ Passionate about enzymes and tackling antibiotic resistance?🧬✨ 🔍 We’re looking for candidates with experience in: ✅ Genetic manipulation ✅ Protein expression & purification ✅ Enzyme biochemistry 🔗 Apply now: lnkd.in/eZRrgJKF
This link will take you to a page that’s not on LinkedIn
lnkd.in
📣 Preprint Alert: How can evolution recruit existing enzymes during bacterial lifestyle changes? Discover how mutations in a bifunctional enzyme 🔄 alter bacterial c-di-GMP metabolism, decoupling it from external polyamine signaling, and steering cells from a planktonic to a biofilm lifestyle 🦠
Biofilm selection constitutively activates c-di-GMP synthesis by the bifunctional enzyme MbaA
Biofilms, in which microbes are encased within a self-produced matrix, represent the primary mode of microbial life. Yet, our understanding of the molecular mechanisms governing biofilm formation rema...
biorxiv.org
🌟 Enzyme Evolution: Marie Curie Fellowship in Tromsø! 🌟 Are you a late-stage PhD student or postdoctoral scholar specializing in biochemistry, molecular biology, or a related discipline? Connect with us to explore the potential for a MSCA collaboration. euraxess.ec.europa.eu/jobs/309710
Call for postdoc candidates interested in applying for an MSCA Postdoctoral Fellowship in Enzyme Evolution
UiT The Arctic University of Norway has established «The Arctic MSCA-PF program» (uit.no/project/arcticmsca) to recruit excellent young researchers planning to apply for a Marie Skƚodowsk
euraxess.ec.europa.eu
Are you interested in biofilms and how evolution regulates them? Follow @oeyvindml.bsky.social PhD defence online. 1045 Central European time! Here is the link to the live stream: uit.cloud.panopto.eu/Panopto/Page...
Are you interested in how #epistasis shapes the AMR evolution? We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. @NatureCatalysis Full read: rdcu.be/dzqjk
Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase
Nature Catalysis - The reasons for epistasis, wherein mutations interact non-additively, are often not fully understood. Now it is found that shifting the rate-limiting step from substrate binding...
rdcu.be
Are you interested in how #epistasis shapes the AMR evolution? We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. @NatureCatalysis Full read: rdcu.be/dzqjk
Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase
Nature Catalysis - The reasons for epistasis, wherein mutations interact non-additively, are often not fully understood. Now it is found that shifting the rate-limiting step from substrate binding...
rdcu.be
Postdoc Opportunity UiTNorgesarktis! 🇳🇴 🧪Join our Arctic MSCA-PF program in Enzyme & AMR evolution. 24-months MSCA in Tromsø's stunning landscape. ⏱️Apply by Feb 16: 3-page CV & 2-page proposal to cfr016@uit.no. #sciencejobs #postdocposition euraxess.ec.europa.eu/jobs/189491
Call for postdoc candidates interested in applying for a MSCA Postdoctoral Fellowship in Enzyme and ...
UiT The Arctic University of Norway has established «The Arctic MSCA-PF program» (uit.no/project/arcticmsca) to recruit excellent young researchers planning to apply for a Marie Skƚodowska-Curie Po...
euraxess.ec.europa.eu
🌟Exciting News! Our AMR & Biofilms research just received an 8M kroner grant from #HelseNord. Big thanks for supporting young researchers and fueling scientific innovation. Grateful to all who've contributed to this success. Looking forward to what comes next.
