Our department chair Edward Chang, MD, kicked off the #ASNR26 opening plenary session highlighting research in the @changlabucsf.bsky.social working to decode the human brain. @theasnr.bsky.social

In the Advances in Epilepsy session, chief neurosurgery resident Anthony Lee, MD, PhD, presented his research with @changlabucsf.bsky.social & @labnowakowski.bsky.social using spatial transcriptomics & micro-electrocorticography to link form and function in the superior temporal gyrus. #AANS2026 🧠🟦

New work from our lab showing the human frontal lobe receives fast, low-level speech information in **parallel** with early speech areas! 🧠🗣️ doi.org/10.1038/s414...

Parallel encoding of speech in human frontal and temporal lobes - Nature Communications

Whether high-order frontal lobe areas receive raw speech input in parallel with early speech areas in the temporal lobe is unclear. Here, the authors show that frontal lobe areas get fast low-level sp...

doi.org

Treating OCD with neurotechnology Researchers at UCSF used iEEG to map brain circuits in severe OCD, identifying the ventral capsule as bridge between the prefrontal cortex and limbic system. Multi-area DBS implantation led to rapid symptom improvement 🧠 #neuroskyence @changlabucsf.bsky.social

Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity - Translational Psychiatry

Translational Psychiatry - Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity

nature.com

Human superior temporal gyrus (STG) encodes the progression of a word as it unfolds in time. The neural activity tracks relative position within the word, regardless of its length, and resets at each new word boundary. #neuroskyence @changlabucsf.bsky.social

Human cortical dynamics of auditory word form encoding

We perceive continuous speech as a series of discrete words, despite the lack of clear acoustic boundaries. The superior temporal gyrus (STG) encodes …

sciencedirect.com

New article in Nature showing that the superior temporal gyrus (STG) encodes language-specific features stronger when listening to the native language. Bilinguals on the other hand shared this higher-level tuning across both of their familiar languages @changlabucsf.bsky.social #neuroskyence

Shared and language-specific phonological processing in the human temporal lobe - Nature

The human superior temporal gyrus processes acoustic–phonetic properties of speech regardless of whether the language is familiar to the listener, but only encodes word boundaries and language-sp...

nature.com

A big year for the @changlabucsf.bsky.social at #SfN25! Congratulations to Edward Chang, MD, who was awarded this year’s Gruber Neuroscience Prize, and to @shaileejain.bsky.social, who was named one of @thetransmitter.bsky.social's Rising Stars in Neuroscience. www.thetransmitter.org/early-career...

Our latest research on the neural basis of speech-motor sequencing is now published in @nathumbehav.nature.com! Check out this high-level explainer video and read the full paper here: t.co/YKJlabr3yb

UCSF Neurosurgery@neurosurgucsf.bsky.social · last yr.

A new @nathumbehav.nature.com study from @changlabucsf.bsky.social identifies a key role for the middle precentral gyrus in coordinating the muscle movements required to speak, challenging the longstanding view that Broca's area controls this process: www.nature.com/articles/s41... 🧠📈 🧪

Introducing DREDge: a new, robust algorithm for **motion correction in electrophys data**. Our collaborative effort is now out in Nature Methods! Free sharing link: tinyurl.com/dredge-elect...

DREDge: robust motion correction for high-density extracellular recordings across species

Nature Methods - DREDge is a software tool for motion correction of high-density electrophysiology recordings. It can handle action potential or local field potential data and is demonstrated on a...

urldefense.com

Ever wonder how the brain works to _stop_ your speech midway?🤫🧠 Our latest work on the neural mechanism for stopping speech production is now out @naturehumbehav.bsky.social! See a brief summary below and the original paper here: www.nature.com/articles/s41...

The application deadline for the Sensation and Action conference 2025 is fast approaching! Join us for an exciting set of talks and for a chance to share your ideas: www.lakeconferences.org