Felix Kaspar

@chemzymes.bsky.social

Group leader @uni-saarland.de | Enzymes, phosphates, spectroscopy. chemzymes.com

Abstract submission NextGenBiocat is open! 👉 nextgenbiocat.org/abstracts-su... Are you a young researcher working in Biocatalysis or related fields? Join us in Munich on 10-11 June for two days full of enzyme research and networking, followed by the BiodeCCodiNNg satellite symposium on 12 June.

Abstract Submission

Abstract submission is open! 1. Download the abstract template and fill it out with your information: Abstract_Template_NextGenBiocat2026Download 2. Access the submission portal by clicking the but…

nextgenbiocat.org

Join us for #Biochemistry2026 by @gdchbiochem.bsky.social with a great lineup of speakers: J. Andexer, H. Bode, S. Hammer, A. Kawamura, A. Deliz Liang, C. de Oliveira Mann, S. Raunser, S. Schwartz, P. Stallforth, C. Tisné, S. Virdee and W. van der Donk. (1/2) veranstaltungen.gdch.de/microsite/in...

GDCh Division of Biochemistry@gdchbiochem.bsky.social · 9mo ago

Are you interested in cutting-edge #Biochemistry and #ChemBio? Join us for the GDCh #Biochemistry2026 conference in Würzburg on March 16th to 18th, 2026. Registration is now open and you can submit an abstract until January 10th, 2026: veranstaltungen.gdch... (1/2)

Psycholog:innen aufgepasst🧑🏽‍🔬💬👩🏻‍💻! Du kommunizierst aktiv über deine Forschung und trägst dazu bei, dass die Psychologie als Wissenschaft sichtbar wird? 📣 Die Deutsche Gesellschaft für Psychologie (DGPs) @dgps.bsky.social schreibt auch 2026 wieder einen Preis zur Wissenschaftskommunikation aus!

@mariehuber.bsky.social reflektiert ehrlich und direkt über die schwierige Vereinbarkeit von Wissenschaftskarriere und Sorgeverantwortung. Ich würde es sogar einen Interessenskonflikt nennen. Den Kindern ist egal wie der nächste Antrag aussieht, aber können wir jetzt bitte zusammen ein Buch lesen?

Amrei Bahr@amreibahr.bsky.social · 11mo ago

„Dauerstellen sind notwendig, aber nicht hinreichend für echte Gleichstellung“, so @mariehuber.bsky.social in dieser eindrücklichen Replik auf uns, die reich an Bsp. ist, was bzgl. Gleichstellung in der Wissenschaft nach wie vor schiefläuft — & Vorschläge macht, wie es besser geht. 🙏 #IchBinHanna

In February, we reported "Heterologous Expression of a Cryptic BGC from Bilophila sp. Provides Access to a Novel Family of Antibacterial Thiazoles". This full journey from bioinformatics via heterologous expression & mutasynthetic studies to new NPs is available here: pubs.acs.org/doi/10.1021/...

Heterologous Expression of a Cryptic BGC from Bilophila sp. Provides Access to a Novel Family of Antibacterial Thiazoles

Human health is greatly influenced by the gut microbiota and microbiota imbalance can lead to the development of diseases. It is widely acknowledged that the interaction of bacteria within competitive ecosystems is influenced by their specialized metabolites, which act, e.g., as antibacterials or siderophores. However, our understanding of the occurrence and impact of such natural products in the human gut microbiome remains very limited. As arylthiazole siderophores are an emerging family of growth-promoting molecules in pathogenic bacteria, we analyzed a metagenomic data set from the human microbiome and thereby identified the bil-BGC, which originates from an uncultured Bilophila strain. Through gene synthesis and BGC assembly, heterologous expression and mutasynthetic experiments, we discovered the arylthiazole natural products bilothiazoles A–F. While established activities of related molecules indicate their involvement in metal-binding and -uptake, which could promote the growth of pathogenic strains, we also found antibiotic activity for some bilothiazoles. This is supported by biosensor-experiments, where bilothiazoles C and E show PrecA-suppressing activity, while bilothiazole F induces PblaZ, a biosensor characteristic for β-lactam antibiotics. These findings serve as a starting point for investigating the role of bilothiazoles in the pathogenicity of Bilophila species in the gut.

pubs.acs.org

Hey #AcademicSky, advice for a #NewPI? How do you introduce a project to a new MSc student? PhD student? Postdoc? You've spent months, years developing an idea and getting funding for it. How much information, and what kind, do you present first? How do you make sure the project becomes theirs?

Has anyone done a "how to work with me" 1-pager that has actually worked, and been useful in the workplace? It's been mentioned to me before and I can't decide if it's a helpful thing