Our paper (@stoplab.bsky.social), in collaboration with the Nojima lab (@pol2rna.bsky.social @chiheron.bsky.social), on the role of chromatin modifier SETD2 at both ends of the transcriptional cycle, is now published in @emboreports.org 🪅 (1/5) link.springer.com/article/10.1...
Chihiron
@chiheron.bsky.social
Chihiro Nakayama Post-doc (JSPS PD) @ https://pol2-nascentrna.net/ RNA transcription regulation (mainly termination✋) 🧫 🥼 💻 ٩( 'ω' )و
My PhD work has been published٩( 'ω' )و Pol II transcription must be terminated at some point. What happens to the cell when Pol II cannot terminate transcription efficiently?
NELF prevents transcriptional readthrough into DNA replication zones in cancer cells. -> link.springer.com/article/10.1...
Extremely happy to share our latest research on the NELF complex in @emboreports.org done in collaboration with the groups of Dr Takayuki Nojima and Dr Yasukazu Daigaku in Japan. link.springer.com/article/10.1...
NELF prevents transcriptional readthrough into DNA replication zones in cancer cells - EMBO Reports
Regulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear how the Pol II transcription program is rewired in cancer to promote u...
link.springer.com
The remarkably long lifespan of bowhead whales could be due to an increased ability to repair DNA mutations, according to research in Nature. go.nature.com/4hzvDN7 🌏 🧪
🚨 New preprint from our labs (STOP lab @stoplab.bsky.social & Nojima lab @pol2rna.bsky.social @pyrolyn.bsky.social)! We've been digging into how chromatin remodeler SETD2 controls the start and end of transcription 👇 www.biorxiv.org/cgi/content/... (1/5)