meetings.embo.org/event/26-rna3 To all 3' end (and RNA, in general) enthusiasts. I'm organising a great conference in Oxford 7th-11th Sept with @lapassmore.bsky.social and Christine Mayr. The lineup of speakers is brilliant! Registration closes 4th May. Please consider it!

PhD position in our lab - 4-year funded by BBSRC and @nrpdtp.bsky.social in collaboration with @earlhaminst.bsky.social and Inspiralis Ltd. Open to UK fee qualifying students - UK citizens and citizens of Ireland (residency requirement), etc biodtp.norwichresearchpark.ac.uk/projects/how...

How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training Partnership

This is open to Home Fee Status candidates only. This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA…

biodtp.norwichresearchpark.ac.uk

The "publish or perish" culture must perish. Scientists need time to think. We just published our Slow Science Manifesto, where we argue that huge changes are needed in the way we fund, publish, and evaluate science. Read more and sign here: www.slow-science.com

My PhD work has been published٩( 'ω' )و Pol II transcription must be terminated at some point. What happens to the cell when Pol II cannot terminate transcription efficiently?

EMBO Reports@emboreports.org · 6mo ago

NELF prevents transcriptional readthrough into DNA replication zones in cancer cells. -> link.springer.com/article/10.1...

Extremely happy to share our latest research on the NELF complex in @emboreports.org done in collaboration with the groups of Dr Takayuki Nojima and Dr Yasukazu Daigaku in Japan. link.springer.com/article/10.1...

NELF prevents transcriptional readthrough into DNA replication zones in cancer cells - EMBO Reports

Regulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear how the Pol II transcription program is rewired in cancer to promote u...

link.springer.com

One week left to apply for the postdoc position at MRC-LMB in Cambridge. Join our team for an exciting project on transcription-coupled splicing to understand human gene regulation 🧬 Feel free to get in touch directly #postdoc #cryoEM #biochemistry

Suyang Zhang@suyangzhang.bsky.social · 6mo ago

🚨Postdoc opportunity🚨Our lab at MRC-LMB Cambridge is recruting a postdoc to study transcription-coupled splicing using cryoEM and endogenous isolation! 🔬 🧬 Please feel free to get in touch directly #postdoc #cryoEM #biochemistry #splicing Apply here by 11 Feb www.nature.com/naturecareer...

Helpful update into UKRI and research council funding changes from Zoe Kleinman @zsk.bsky.social But please more focus on 2 things... 1) Immediate effects (eg funding decisions expected in March) 2) Likely disproportionate effects on early career scientists www.bbc.co.uk/news/article...

UK’s £8bn research fund faces “hard decisions” as it pauses new grants

UKRI boss Ian Chapman said it had been told by the government to

bbc.co.uk

Opportunity for doing a PhD in my lab under the MRC-DTP programme, working on redefining the role of signal peptidase complex in cellular signalling. warwick.ac.uk/fac/sci/life... Deadline 2nd March 2026. www.findaphd.com/phds/program...

FindAPhD : Medical Research Council-funded DTP in Interdisciplinary Biomedical Research at University of Warwick

Apply for a PhD: Medical Research Council-funded DTP in Interdisciplinary Biomedical Research at University of Warwick

findaphd.com

Excited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...

I am happy to have contributed to this study published in @cp-cellreports.bsky.social and led by @ahellab.bsky.social group, on the interplay between two ADP-ribosylation (ADPr) hydrolases TARG1 and PARG, revealing that PARG regulates TARG1 protein level. www.sciencedirect.com/science/arti...

PARG regulates the proteasomal degradation of TARG1

ADP-ribosylation (ADPr) is a reversible modification of macromolecules critical for the regulation of genome stability, stress responses, and proteost…

sciencedirect.com

#30DayMapChallenge #30DayMapChallenge2025 #30DayMapChallengeRbanism #30DayMapChallengeR Day 7: Accessibility. Access, A Matter of Means. by @ineszaid.bsky.social #GeoData #rstats #DataViz #Maps #SpatialViz

Another exciting opportunity @dunnschool.bsky.social ! Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health Please help us find great applicants

The Dunn School, Oxford@dunnschool.bsky.social · 11mo ago

We're hiring (again)! We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly) If you have a great record and exciting plans, consider joining our thriving and welcoming department www.path.ox.ac.uk/vacancy/asso...

Hi everyone! New to the community and thrilled to be starting a lab @warwicklifesci.bsky.social focused on the intersection of membrane protein biogenesis and gene regulation. Looking forward to connect with fellow researchers. #AcademicSky #NewLab #CellBiology #Science #Research #MembraneProteins

In this study, Mimoso et al. show that Restrictor serves as a transcriptional safeguard that suppresses the spurious transcription of non-coding RNAs, while preserving mRNA transcription. Learn more here: ➡️ tinyurl.com/gd352654

Transcription and Chromatin UK is back! This time in Manchester, 17th-19th September. Send your abstract by 17th July for the opportunity to discuss your work with the UK RNA and epigenetics community, and with leading experts from abroad. Click the link below and spread the word!

Biochemical Society@biochemsoc.bsky.social · last yr.

Taking place on 17-19 September 2025, Transcription and Chromatin UK will showcase cutting-edge research and is a ‘mustattend’ for anyone within the transcription and epigenetics community🧪. Register now: www.eventsforce.net/biochemsoc/2...

EMBO is delighted to announce that this year the EMBO Gold Medal is awarded to Tanmay Bharat @tbharat-lab.bsky.social ‬ @mrclmb.bsky.social and David Bikard @dbikard.bsky.social @pasteur.fr for their remarkable contributions to the #LifeSciences. www.embo.org/press-releas... #award 🧪

EMBO Gold Medal 2025 awarded to Tanmay Bharat and David Bikard – Press releases – EMBO

Every year, EMBO awards the Gold Medal to group leaders in the early stages of their careers for their remarkable contributions to the life sciences in

embo.org

Nice perspective by Michael Nagel and Dylan Taatjes in @cp-molcell.bsky.social Regulation of RNA polymerase II transcription through re-initiation and bursting www.cell.com/molecular-ce...

Built a peer review system that doesn’t take forever. Spoiler: scientists love it. Huge thanks to the amazing team at The Company of Biologists for making Fast & Fair happen. Read the preprint: bit.ly/4iZ30st #biologists100 @biologists.bsky.social @biologyopen.bsky.social

Fast & Fair peer review: a pilot study demonstrating feasibility of rapid, high-quality peer review in a biology journal

Traditional peer review is slow, often delayed by the time-consuming process of identifying reviewers and lengthy review turnaround times. This study tests the feasibility of the Fast & Fair peer revi...

bit.ly

I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...

Save the date! On March 25th, We'll dive into Nanofluidic tools for studying DNA repair with Fredrik Westerlund and R-loops & genome instability with Sidrit Uruci & Agnese Cristini. Don't miss out! 🗓️ #DNARepair #GenomeStability

Interesting idea: get the sick super-rich to pay for clinical trials Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....) www.theguardian.com/news/2025/ma...

Many life-saving drugs fail for lack of funding. But there’s a solution: desperate rich people

Each year, hundreds of potentially world-changing treatments are discarded because scientists run out of cash. But where big pharma or altruists fear to tread, my friend and I have a solution. It’s re...

theguardian.com

We have an exciting collaborative #PhD project with Dr Catherine Jopling, University of Nottingham, on understanding the role of cancer-associated SF3B1 K700E mutation in microRNA expression and biogenesis. Application deadline: 10th January 2025. More information: more.bham.ac.uk/mrc-aim/phd-...

Excited to share our new paper @genomeresearch.bsky.social about PlatinumCRISPr thanks to @ihaussmann.bsky.social, @roliarnold.bsky.social, @davidmcquarrie.bsky.social & team. sgRNA folding matters - our online tool PlatinumCRISPr selects correctly folded sgRNAs. genome.cshlp.org/content/earl...

We have an exciting and multidisciplinary fully-funded BBSRC MIBTP #PhD position between my lab and Massimo Cavallaro's lab coupling genomics, transcriptomics, and mathematical modelling to investigate the regulation of gene expression. Deadline: 16th January 2025. www.findaphd.com/phds/project...

Unravelling age-related gene expression dysregulation through system biology and mathematical modelling. at University of Leicester on FindAPhD.com

PhD Project - Unravelling age-related gene expression dysregulation through system biology and mathematical modelling. at University of Leicester, listed on FindAPhD.com

findaphd.com

What happens when you overexpress one subunit of the RNA Pol II? Well, it depends on the subunit, but all deregulate transcription and induce genome instability @agagambus.bsky.social www.biorxiv.org/content/10.1...

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription

Independently of the pathways or circuits deregulated in cancer cells, these present altered transcription patterns, often also direct consequence of deregulation of transcription factors. In this sen...

biorxiv.org

🎓 Exciting #PhD opportunity in our lab at @mcbleicester.bsky.social and @leicstructbio.bsky.social. Join the BBSRC-funded MIBTP programme for a 4-year fully funded studentship with comprehensive training in year 1 + research project years 2-4. #PhDSky #AcademicSky Details: tinyurl.com/4fhavzxh

Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester on FindAPhD.com

PhD Project - Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester, listed on FindAPhD.com

tinyurl.com