Mapping Dysfunctional Protein-Protein Interactions in Disease

Protein-protein interaction (PPI) networks are dynamically remodeled in disease, yet most systems biology approaches focus on changes in protein ...

app.jove.com

Mapping Dysfunctional Protein-Protein Interactions in Disease

Memorial Sloan Kettering Cancer Center. Here, we present a protocol to enable the capture and identification of disease-specific protein-protein interactions from native cells and tissues using chemi...

app.jove.com

Mapping Dysfunctional Protein-Protein Interactions in Disease

Memorial Sloan Kettering Cancer Center. Here, we present a protocol to enable the capture and identification of disease-specific protein-protein interactions from native cells and tissues using chemi...

app.jove.com

PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease

Recent discoveries reveal that post-translational modifications (PTMs) do more than regulate protein activity – they encode conformational states that…

sciencedirect.com

When Modifications Rewrite Networks: How PTMs Reprogram Chaperones into Epichaperomes

communities.springernature.com

PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease

Recent discoveries reveal that post-translational modifications (PTMs) do more than regulate protein activity – they encode conformational states that…

sciencedirect.com

Redirecting

doi.org

Introducing dysfunctional Protein-Protein Interactome (dfPPI) – A platform for systems-level protein-protein interaction (PPI) dysfunction investigation in disease

Protein-protein interactions (PPIs) play a crucial role in cellular function and disease manifestation, with dysfunctions in PPI networks providing a …

sciencedirect.com

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications

Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...

nature.com

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications

Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...

nature.com

Introducing dysfunctional Protein-Protein Interactome (dfPPI) – A platform for systems-level protein-protein interaction (PPI) dysfunction investigation in disease

Protein-protein interactions (PPIs) play a crucial role in cellular function and disease manifestation, with dysfunctions in PPI networks providing a …

sciencedirect.com

Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum

Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...

researchsquare.com

Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases

The complexity of disease biology extends beyond mutations or overexpression, encompassing stress-induced mechanisms that reshape proteins into pathological assemblies. Epichaperomes, stable and disea...

pubs.rsc.org

Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum

Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...

researchsquare.com

Beyond the Headlines: Ensuring Integrity While Advancing Alzheimer’s Research

How do we ensure scientific integrity while advancing urgently needed treatments? Sensationalized media narratives aren’t the answer. While accountability is essential, we must also recognize the grou...

communities.springernature.com

Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum

Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...

researchsquare.com

Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum

Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...

researchsquare.com

Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum

Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...

researchsquare.com