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Chris Chang

@christhechang.bsky.social

Edward and Virginia Taylor Professor of Chemistry, Princeton University. Excited to study the chemistry and biology of the elements! Find out more about us at https://chrischang.chemistry.princeton.edu

23 Posts2491 Follower342 Folgt
Chris Chang@christhechang.bsky.social · 10mo ago

Excited to share work out in @jacs.acspublications.org led by Yuxuan and @genlichem.bsky.social on activity-based sensing of acetaldehyde using an inverse electron-demand Diels-Alder reaction, enabling selective detection of two-carbon metabolism! pubs.acs.org/doi/10.1021/...

An Inverse Electron-Demand Diels–Alder Approach to Selective Activity-Based Sensing of Acetaldehyde in Living Cells

Acetaldehyde (AA) is a reactive aldehyde primarily produced in cells as a metabolic intermediate during ethanol oxidation. Excess AA, often resulting from impaired AA detoxification, leads to aberrant...

pubs.acs.org

Chris Chang@christhechang.bsky.social · 11mo ago

Copper regulates the evolution of REM sleep and transition of animals from water to land! It all relies on a new “metalloadaptor” function for RAD23B linking Cu uptake to distribution to multiple Cu targets. Tong and Dan co-led this @cp-molcell.bsky.social story www.sciencedirect.com/science/arti...

RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity

Increasing brain complexity is a major step in the evolution of species. Here, we show that, in the transition from amphibians to reptiles, the DNA re…

sciencedirect.com

Chris Chang@christhechang.bsky.social · 11mo ago

Happy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...

An Alkyne-Directed Cleavage Approach for Activity-Based Cu(I) Sensing Reveals Manganese-Promoted Sensitization of Cuproptosis

Copper is an essential element for sustaining life. However, disruptions in copper homeostasis underpin disease, as illustrated by cuproptosis, an emerging form of cell death resulting from aberrant a...

pubs.acs.org

Chris Chang@christhechang.bsky.social · 2y ago

Activity-based sensors identify cuproplasia and ferroplasia as druggable metal vulnerabilities in cancer! With @ginadenicola.bsky.social and Adam Renslo, we profile cancer cell lines to find those sensitive to Cu or Fe chelation www.pnas.org/doi/10.1073/... www.pnas.org/doi/10.1073/... #chemsky 1/n

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

Chris Chang@christhechang.bsky.social · 2y ago

First Princeton paper! Activity-based sensing plus narrow Raman signatures enable multiplex copper imaging, revealing crosstalk between high antioxidant response element NRF2 activation and low labile Cu in cancer. Fun project with Wei Min’s lab at Columbia! #chemsky pubs.acs.org/doi/10.1021/...

An Activity-Based Sensing Approach to Multiplex Mapping of Labile Copper Pools by Stimulated Raman Scattering

Molecular imaging with analyte-responsive probes offers a powerful chemical approach to studying biological processes. Many reagents for bioimaging employ a fluorescence readout, but the relatively br...

pubs.acs.org