Editorial: Seeing It Through — Lessons from a Retinal Stroke Trial nej.md/3M8qKiT

CREST-2 trials: For patients with asymptomatic, high-grade carotid-artery stenosis, improvements in carotid endarterectomy, stenting, and medical therapy have challenged our understanding of appropriate treatments. Research findings are summarized in a new Quick Take video. nej.md/4py7Wap

Togni et al: Association of Serial Ventricular Routine Cerebrospinal Fluid Findings with Complications and Outcome in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Observational Study Link: link.springer.com/ar... @neurocritical #neurocritcare

Distinct cutaneous α-synuclein signatures in body-first and brain-first Parkinson’s disease subtypes academic.oup.com/brain/advanc...

Distinct cutaneous α-synuclein signatures in body-first and brain-first Parkinson’s disease subtypes

Liu et al. show that cutaneous α-synuclein signatures differ between brain-first and body-first subtypes of Parkinson’s disease, providing direct pathologi

academic.oup.com

Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients. 📝 This Review discusses PFO-associated stroke management. ja.ma/430lxyZ

#eNeuro | SpinalTRAQ: A Novel Pipeline for Volumetric Cervical Spinal Cord Analysis Identifies the Corticospinal Tract Synaptic Projectome in Healthy and Post-stroke Mice https://doi.org/10.1523/ENEURO.0276-25.2025

Chen et al. report in “Efficacy and Safety of Twelve Anti-Dyskinetic Drugs in Parkinson's Disease” that amantadine ER is more effective than IR for dyskinesia, and both reduce OFF time better than other drugs. 📚 Read now: onlinelibrary.wiley.com/doi/10.1111/... #Neurology @ean.org #WileyNeuro

RCT: For patients with spinal cord injury, augmenting mean arterial pressure >85 vs 65 mmHg did not improve 6‐month neurological outcomes, and the MAP >85 group had more respiratory complications, longer mechanical ventilation, and worse organ dysfunction. #NCS2025 ja.ma/4naOW1t

To shunt or not to shunt, that is the (NPH) question? The first large randomized trial of shunting for normal pressure hydrocephalus (NPH) just dropped in NEJM, and there was clear benefit for walking, and it favored the group receiving shunts. @parkinsondotorg.bsky.social

What is the 2025 update on antibody therapies for Alzheimer’s? Spoiler alert: think EAC or effectiveness, access and cost. A critically important topic in a recent piece in JAMA. Early adopters enthusiastic, safety signals remain consistent w/ trials, questions remain. @alzassociation.bsky.social

A new study by Puja Agarwal, Sonal Agrawal, Julie Schneider, et al. @rushalzheimers.bsky.social provides more evidence that #MIND & other diets like it can protect against #Dementia – as well as giving us some clues as to why. Learn More @jamanetworkopen.com 👉 jamanetwork.com/journals/jam...

Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients. This review discusses PFO-associated stroke management. ja.ma/4orDOyr

🚨 New 2-in-1 paper: a review on #EEG brain oscillations (www.sciencedirect.com/science/arti...) and a website with recorded talks from a symposium that featured 8 speakers discussing the present and future of the field (brain-waves-workshop.github.io/2024/). 🧠 #neuroimaging #neuroskyence

EEG brain waves and alpha rhythms: Past, current and future direction

Nearly a century after the first EEG recordings, we assess the progress made in EEG research, focusing on the challenges, novel theories and methods, …

sciencedirect.com

Neurofilament light chain evaluated with a new automated commercially available method for outcome prediction in out-of-hospital cardiac arrest patients www.resuscitationjournal.com/article/S03... #Resuscitation

SpikeNet2, a deep-learning model shown to achieve expert-level performance in detecting epileptiform discharges from EEG recordings while significantly reducing false positives, demonstrates strong generalizability across diverse datasets. Learn more: nejm.ai/4lq1Qr4 #AI #MedSky #NeuroSky

#Cardiacarrest from neurological causes: for whom the brain tolls - Resuscitation www.resuscitationjournal.com/article/S030... @resuscitation.bsky.social @stlegriel.bsky.social #marinepaul

Cardiac arrest from neurological causes: for whom the brain tolls

Cardiac arrest of neurological cause (CA-NC) is an entity whose incidence is unknown. The main reason for this is that the medical literature is mainly concerned with cardiac arrest due to cardiac cau...

resuscitationjournal.com

Serum neurofilament light chain and multimodal neuroprognostication after cardiac arrest – a retrospective cohort study www.resuscitationjournal.com/article/S03... #Resuscitation

Neurologic etiologies of cardiac arrest are associated with early withdrawal of life-sustaining therapy www.resuscitationjournal.com/article/S03... #Resuscitation

A pooled analysis of of the four INTERACT trials suggests intensive blood pressure-lowering initiated within several hours of intracerebral haemorrhage onset was safe and improved functional recovery, without a clear effect on haematoma growth. Check it out in our latest issue: tinyurl.com/mrnmv5f6

Al-Salahat et al: Outcomes of Spinal Cord Infarction with Thrombolysis: A Nationwide Analysis Link: link.springer.com/ar... @neurocritical #neurocritcare

Brain injury after cardiac arrest is not as homogeneous and global as previously thought ❗️ We identified different histopathological phenotypes in 319 (!) patients with postmortem brain autopsies 🧠 🔬 @resuscitation.bsky.social @neurocritical.bsky.social www.sciencedirect.com/science/arti...

Histopathological patterns of hypoxic-ischemic encephalopathy after cardiac arrest: A retrospective brain autopsy study of 319 patients

Understanding the pathophysiology of hypoxic-ischemic encephalopathy (HIE) provides important knowledge for the interpretation of neuroprognostic inve…

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Do we need to rethink near-death experiences? What’s really happening in the brain? NDEs might be a hardwired coping strategy: the dissociation, calmness, and detachment when facing death may actually be an evolutionarily protective response.

Is the "New Brunswick Neurological Syndrome of Unknown Cause" actually a new disease? The data out strongly suggest NO. We must carefully study and share data on clusters of 'unknown' cases, and especially those cases that draw intense attention from the media. Examine and use pathology.

‼️Largest cohort of postmortem 🧠 autopsies after cardiac arrest ‼️ @resusplus.bsky.social @ercresus.bsky.social Correlation between 🧠 🔬 Microscopic brain injury ✳️ Duration of resuscitation ✳️ Regain of consciousness 📖Read more: www.sciencedirect.com/science/arti...

Duration of resuscitation, regain of consciousness and histopathological severity of hypoxic-ischemic encephalopathy after cardiac arrest

To study the histopathologically quantified severity of hypoxic-ischemic encephalopathy (HIE) in deceased cardiac arrest unbiased by death causes and …

sciencedirect.com

Zhang et al: Contralateral Neurovascular Coupling in Patients with Ischemic Stroke After Endovascular Thrombectomy Link:link.springer.com/ar... @neurocritical #neurocritcare

Neurological problems are a significant concern for patients receiving CAR T-cell therapy, yet there are no best practice guidelines. In @thelancetoncol.bsky.social, a Review provides guidance on managing neurological issues associated with CAR T-cell therapy: tinyurl.com/3fxd5vtt

3/ Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of cohort studies🔗 tinyurl.com/4z6w3vv5

Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of two prospective cohort studies

Our findings suggest that WLST decisions are significantly more common in patients with ABI versus patients without ABI and occur earlier in this group. The rationale for early WLST following ABI warr...

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OP-ED: "Consciousness or pseudo-consciousness? A clash of two paradigms" by Meritorious Investigator Christof Koch and collaborators 🧠📈 www.nature.com/articles/s41...

Consciousness or pseudo-consciousness? A clash of two paradigms - Nature Neuroscience

Integrated information theory (IIT) starts from consciousness, which is subjective, and accounts for its presence and quality in objective, testable terms. Attempts to label as ‘pseudoscientific’ a th...

nature.com

Then, Consciousness or pseudo-consciousness? A clash of two paradigms www.nature.com/articles/s41...

Consciousness or pseudo-consciousness? A clash of two paradigms - Nature Neuroscience

Integrated information theory (IIT) starts from consciousness, which is subjective, and accounts for its presence and quality in objective, testable terms. Attempts to label as ‘pseudoscientific’ a th...

nature.com

Pleasure of contributing to Handbook of Clinical Neurology, Vol. 207: „Coma, Stupor, and Related Disorders of Consciousness“ 🌟 @neurocritical.bsky.social Check out our chapter ✅ Title: „Evoked potentials in patients with disorders of consciousness“ www.sciencedirect.com/science/arti...

Evoked potentials in patients with disorders of consciousness

Acute coma in the intensive care unit and persistent disorders of consciousness (DoC) in neuro-rehabilitation are frequent in patients with hypoxic–is…

sciencedirect.com