Researchers Xiuli Dan, et al. have ID'd a previously unrecognized feature of #Alzheimers, mitochondrial plaques. Seen in both preclinical models of Alzheimer's & human brain tissue, they appear to form independently of traditional #AmyloidPlaques. Nature Neuroscience 👉 www.nature.com/articles/s41...

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer’s disease - Nature Neuroscience

Researchers identify mitochondrial plaques, a previously unrecognized and highly acidic mitochondria-based pathological structure in Alzheimer’s disease, and demonstrate that they result from the dual...

nature.com

Our new review article examines the structural variety, distribution, and physicochemical properties of #ChlorogenicAcids (CGAs), identifying coffee and green coffee as the leading dietary sources of these compounds. Full Text @mdpiopenaccess.bsky.social | Nutrients 👉 www.mdpi.com/2072-6643/18...

Researchers Andrei Irimia, et al. at the University of Southern California have developed an imaging-derived technique that uses #ArtificialIntelligence to generate detailed maps that highlight differences in how distinct parts of the brain age. Learn More @pnas.org 👉 www.pnas.org/doi/10.1073/...

Here, Bryce Connors, Jaron Thompson, Manasi Subhash Gangan, et al. "integrate #MachineLearning, Bayesian optimization and high-throughput community construction to investigate how dietary fibers shape health-relevant functions of human #Gut #Microbial communities." 👉 www.nature.com/articles/s41...

Designing fiber–gut microbiome interactions with active learning - Nature Chemical Biology

Dietary fibers are a primary energy source for gut bacteria and shape the composition and function of the microbiome. Now, an active learning approach integrating explainable machine learning, Bayesia...

nature.com

COMING UP! The Microbiome & Probiotics R&D & Business Collaboration Forum brings together industry leaders, researchers, & innovators to facilitate collaboration & knowledge exchange in the field of #Microbiome research & #Probiotic development. Learn More 👉 global-engage.com/wp-content/u...

NEW STUDY | OUT NOW! Here, Dr. Carlos Toro & I use machine-learning models on NHANES data to demonstrate that combining demographic profiles w/ exposomic biomarkers is powerful strategy for predicting cognitive performance. @mdpiopenaccess.bsky.social | Brain Sciences 👉 www.mdpi.com/2076-3425/16...

Between the healthy version & the large plaques it forms in #Alzheimers, there is an intermediate state of #Amyloid beta. Researchers @yalemedicine.bsky.social have now ID'd this structure, which could open new, more effective treatment options. Nature Communications 👉 www.nature.com/articles/s41...

New findings by researchers Léa Décarie-Spain, Scott Kanoski, et al. suggest that the #VagusNerve may carry information that helps the brain store memories. Learn more in Nature Communications www.nature.com/articles/s41... @uscedu.bsky.social @bucknellu.bsky.social @umontreal-en.bsky.social

The vagus nerve promotes memory in rats via nutrient-induced septo-hippocampal acetylcholine signaling - Nature Communications

The authors find that nutrient consumption enhances memory through vagus nerve-mediated septo-hippocampal acetylcholine signaling. Either surgical ablation of this pathway or Western diet exposure, wh...

nature.com

Researchers Niels Plath, Mark Fiers, Bart De Strooper, et al. have "identified a possible tipping point that helps determine whether #Alzheimers - related brain changes lead to #Dementia." @viblifesciences.bsky.social Learn More in Nature Medicine 👉 www.nature.com/articles/s41...

Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience - Nature Medicine

Microglia cellular changes underlie divergent resilience-associated mechanisms in human aging.

nature.com

Are SuperAgers simply people who inherited unusually low genetic risk for #AlzheimersDisease? Learn More in Alzheimer's Research & Therapy link.springer.com/article/10.1... @emoryuniversity.bsky.social @westernu.ca

SuperAging is not the inverse of common-variant Alzheimer’s risk: evidence across genetic ancestries - Alzheimer's Research & Therapy

Background As longevity increases and the population over age 65 expands, advancing age remains the most reliable predictor of cognitive decline, highlighting the need to identify biological mechanism...

link.springer.com

Jian Ma, et al. generated multiscale view connecting genome structure, gene expression, & tissue organization in #Alzheimers. They linked alterations in genome folding to disrupted gene regulation, providing a new layer of insight into biology of #Neurodegeneration. 👉 www.science.org/doi/10.1126/...

Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer’s disease

Alzheimer’s disease (AD) disrupts brain function through cell type–specific transcriptomic and epigenomic alterations, yet the contribution of three-dimensional (3D) genome organization to AD remains ...

science.org

The brain continuously produces metabolic waste that must be removed. Yet one question has remained: How does #CerebrospinalFluid cross the arachnoid membrane? A team, led by Gou Young Koh at IBS, has identified the missing anatomical gateway. @cellpress.bsky.social 👉 www.cell.com/cell/fulltex...

Here, Chuang Liang, Godfrey Pearlson, Shile Qi, @vcalhoun.bsky.social, et al. "systematically compare brain aging across multiple common brain disorders and explore the brain patterns and biological processes underlying these differences." @plosmedicine.org 👉 journals.plos.org/plosmedicine...

Brain aging patterns among nine neurological disorders: A case-control study

In this case-control study, Chuang Liang and colleagues systematically compare brain aging patterns and biological processes across multiple common brain disorders.

journals.plos.org

Here, Tomoyuki Murano, et al. at Fujita Health University demonstrate that chronically-repeated brain stimulation triggers plasticity of the cellular state, revealing form of stimulus-regulated nuclear reprogramming w/ potential clinical utility. Nature Communications www.nature.com/articles/s41...

Repetitive neuronal activation regulates cellular maturation state via nuclear reprogramming - Nature Communications

Here, the authors find repeated stimulation of dentate gyrus neurons in mice reverts post-mitotic mature neurons to an immature-like state through reactivation of cell-cycle-like programs—a previously...

nature.com

New reseach by Roberto Vicinanza, Pasquale Pignatelli, Pinchas Cohen, et al. has found that the #MediterraneanDiet may influence aging through tiny proteins produced inside the cell’s #Mitochondria. Full Study in Frontiers in Nutrition www.frontiersin.org/journals/nut... @uscedu.bsky.social

Researchers Nicholas Constantino, Shannon Macauley et al. at University of Kentucky found that #Microglia are the main drivers of sleep loss in an animal model of Alzheimer's. Learn More in #Alzheimers & #Dementia | @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

A drug originally developed for spinal cord injury may offer a fresh approach to treating #Alzheimers. In mouse studies, KCL-286 repaired dangerous DNA damage, reduced #Inflammation & targeted multiple disease-related pathways. @febsopenbio.bsky.social 👉 febs.onlinelibrary.wiley.com/doi/10.1002/...

FEBS Press

Repair of neuronal DNA damage in Alzheimer's disease by KCL-286. (A) Amyloid-β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double-strand breaks and glial activation. (B)....

febs.onlinelibrary.wiley.com

Study from Vanessa Young, et al. @uthealthsa.bsky.social suggests regularly sleeping long hours each night assoc w/ higher levels of an #Alzheimers -related protein in blood, even accounting for other health factors. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

EXCITING NEWS from #AAIC2026! New study shows biomarker p-tau217 accurately predicts #Alzheimers risk, w/ hi-level cases showing a 38% risk of cognitive impairment w/in 5 years & 78% risk w/in 10 years for asymptomatic individuals w/ high baseline levels. @jama.com 👉 jamanetwork.com/journals/jam...

Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment

This cohort study examines the absolute risk of progression to cognitive impairment and rates of cognitive decline per the blood-based biomarker plasma phosphorylated tau 217 (p-tau217) among cognitiv...

jamanetwork.com

New study by Charlotte Luster, Bobak Abdolmohammadi, Michael Mastrodicasa, et al. found that while NFL players had lower mortality on average compared to national rates, they were four times more likely to experience #Neurodegenerative mortality. eClinicalMedicine www.thelancet.com/journals/ecl...

Neurodegenerative mortality among National Football League Players

Neurodegenerative mortality was nearly four times higher in NFL players compared to the general population and remained threefold higher after accounting for competing risks. Together, these findings ...

thelancet.com

Announced at the @alzassociation.bsky.social Int'l Conference in London, the Consortium for Biomedical Research & #ArtificialIntelligence in #Neurodegeneration (C-BRAIN) has officially launched three open-source AI tools. Learn More @neurosciencenews.bsky.social👉 neurosciencenews.com/open-source-...

Open-Source AI Tools for Alzheimer's - Neuroscience News

Researchers announce the launch of C-BRAIN, an open-source AI scientist deploying three free computational tools to accelerate Alzheimer's drug discovery.

neurosciencenews.com

New Study by Renée Kosonen, Kristie Stefanoska, Yijun Lin, et al. has revealed that tau, best known for its connection to #Alzheimers, is also essential for creating long lasting memories. At Nature Communications 👉 www.nature.com/articles/s41... Science Daily 👉 www.sciencedaily.com/releases/202...

A Great Article - Offering both an informative and important overview of the challenges faced by patients, clinicians and researchers in the field of Alzheimer disease. @nature.com 👉 www.nature.com/articles/d41...

How to avoid dementia — what the science really says

Ambitious studies have been examining the protective effects of diet, exercise and socializing — with surprising results.

nature.com

Excited to share this new protocol paper! As #Botanicals & nutritional supplements gain popularity for physical & #MentalHealth, rigorous human studies to validate absorption, #Bioavailability, & physiological effects are more important than ever. At Elsevier 🌿 www.sciencedirect.com/science/arti...

Here, Linda Klavinskis, Sandrine Thuret, et al. @kingscollegelondon.bsky.social offer insight into how long-term inflammation may contribute to cognitive decline in disorders like #Alzheimers #Ageing #Depression & lingering neurological effects of viral infections. 👉 www.nature.com/articles/s41...

TNF-α induces type I IFN signalling to suppress neurogenesis and recruit T cells - Nature Communications

Here, the authors show that chronic TNF-α activates type I interferon signalling in human hippocampal stem cells, suppressing neurogenesis and promoting T-cell recruitment, thereby reprogramming cells...

nature.com

Here, Xia Zhang, et al. establish a specific link between cardiac dysfunction & cognitive decline based on microstructural brain alterations & ID a 'heart-brain continuum' where routine cardiac biomarkers predict future brain microstructural damage. @sfnjournals.bsky.social 👉 doi.org/10.1523/JNEU...

Research led by investigators Marc Weinberg, Mahesh Chandra Kodali, Zhaozhi Li, et al. suggests that the Bacillus Calmette-Guérin (BCG) vaccine may remodel the human brain’s immune environment. @massgeneralbrigham.bsky.social Learn More in Communications Medicine 👉 www.nature.com/articles/s43...

Bacillus Calmette–Guérin (BCG) immunotherapy reprograms CNS immunity and alters Alzheimer’s biomarkers: results from two open-label clinical trials - Communications Medicine

Weinberg, Kodali, Li et al. investigate the effects of BCG (tuberculosis) vaccination on brain and blood immune responses and Alzheimer’s-related biomarkers in older adults. They find durable immune r...

nature.com

It was so exciting to chair the roundtable “Bridging Multimodal Biomedical Data for Neuro-Clinical Translation | Multimodal Data Fusion for Early Interception of #AlzheimersDisease” at the 11th Neurological Disorders Summit! Thank you to my colleagues for joining me for this fantastic discussion.

It was a fantastic morning at the 11th Neurological Disorders Summit 2026 where I gave a Plenary presentation: “Role of the Immune T Regulatory Cells in Mood Disorders and Alzheimer's Disease Phenotype as a therapeutic target in Altered Gut-brain Axis cross-talking”.

Important Study! Here, Yael Rosen-Lang, Agathe Vrillon, Shlomit Pasternak, et al. set out to evaluate accuracy of emerging #AlzheimersDisease blood biomarkers in veterans with and without a #TraumaticBainInjury history. Learn More in JAMA Network 👉 jamanetwork.com/journals/jam...

Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers

This diagnostic study investigates the accuracy of the plasma phosphorylated tau 217 (p-tau217)/amyloid-β 42 (Aβ42) ratio test for detecting amyloid–positron emission tomography positivity for an Alzh...

jamanetwork.com