How does diet causally influence tumor development? Fat composition — not amount — rewires the pancreatic lipidome to control ferroptosis sensitivity and tumorigenesis. Grateful to all collaborators and excited to build on this.

Muzumdar Lab@muzumdarlab.bsky.social · 5mo ago

🔔Why does high-fat diet promote #PancreaticCancer? And does the type of fat matter? Epidemiologists have asked this for decades. Our new paper in Cancer Discovery @theaacr.bsky.social shows that fat composition — not just fat quantity — governs tumorigenesis. aacrjournals.org/cancerdiscov...

🎉 So proud of my wife Natasha Pinto Medici on her latest co–first author paper in @ScienceTransMed! 🚀 Her team introduces TMAB3 — a tumor-targeted, RNA-binding antibody that delivers RNA directly into tumors after systemic injection. www.science.org/doi/10.1126/...

Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer

A cell-penetrating and RNA binding antibody forms noncovalent complexes with an immunogenic RNA to target tumors and achieve antitumor efficacy.

science.org

Way to go, @xiangyuge.bsky.social, for a fantastic talk on how #PI3K governs resistance to #KRAS inhibition in #PancreaticCancer cells @faseborg.bsky.social Protein Phosphorylation! @yalepathology.bsky.social @yalecancer.bsky.social. Check out her preprint: www.biorxiv.org/content/10.1...

Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition

Despite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious obstacle....

biorxiv.org

PI3K takes the spotlight when KRAS is inhibited in PDAC. Fantastic preprint from @xiangyuge.bsky.social now up!

Muzumdar Lab@muzumdarlab.bsky.social · last yr.

1/🚨 New preprint out!🚨 We uncovered that #PI3K-driven wild-type RAS activation bypasses #KRAS inhibition in pancreatic adenocarcinoma (#PDAC) to drive #resistance. 🔑PI3K isn’t just a downstream RAS effector – it can be an upstream RAS regulator. 📄 www.biorxiv.org/content/10.1...

🔁 Check out our new preprint exploring how dietary fats influence pancreatic cancer progression through ferroptosis sensitivity! 🦠🔥 In our model, MUFAs promote tumorigenesis, while PUFAs show protective effects. Read more here 📄👇 #CancerResearch #Ferroptosis #LipidMetabolism #bioRxiv”

Muzumdar Lab@muzumdarlab.bsky.social · last yr.

9/ 💬 Excited to discuss! Questions, feedback, and collaborations welcome! 🤝 #CancerBiology #DietAndCancer #Ferroptosis #PancreaticCancer www.biorxiv.org/content/10.1...