With the recent FDA approval of #daraxonrasib for patients with #pancreaticcancer, there is a lot of excitement among patients and clinicians. Dr. Alexander Jordan: "The results of the trial were exciting because daraxonrasib almost doubled overall survival and risk of death ⬇️ by 60%."

🧬NEW PAPER🧬 To what extent is cancer development deterministic? Does the germline genome affect that predictability? Find out in our #StrainDifferences paper @nature.com "Genetic background sets the trajectory of experimental cancer evolution" www.nature.com/articles/s41... 🧵[1/14]

Genetic background sets the trajectory of experimental cancer evolution - Nature

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

nature.com

Please repost! We are seeking #PostDocs to join our lab @yale.edu @yalecancer.bsky.social to study #genetic and #host drivers of #PancreaticCancer and #LungCancer. Check out our newly updated website for more lab details! medicine.yale.edu/lab/muzumdar/

A new Yale-led study published in #JNCI #CancerSpectrum found that #Veterans living in neighborhoods with higher incomes and education levels had slightly increased risk of #pancreaticcancer. medicine.yale.edu/cancer/news-...

Does a Person’s Neighborhood Impact Their Risk of Pancreatic Cancer?

A new Yale-led study published in JNCI Cancer Spectrum is the first to examine the overall relationship between pancreatic cancer and neighborhood-level

medicine.yale.edu

In a recent study, YSM researchers investigate how PI3K enables #pancreatic #cancer cells to resist KRAS inhibitors by activating wild-type RAS signaling, suggesting combined PI3K-KRAS targeting as a #therapeutic strategy. Learn more: medicine.yale.edu/publication-...

A new YSM-led study shows how dietary #fat composition shapes #pancreatic #cancer risk. The results are published in Cancer Discovery: medicine.yale.edu/publication-...

We’re starting to understand something important about diet and pancreatic cancer: it’s not just how much fat we eat, it’s the types of fats in our diet. In preclinical models, some fats were linked to faster tumor growth, while others helped slow it down by making cancer cells more vulnerable.

New research from @muzumdarlab.bsky.social identifies PI3K-driven wild-type RAS activation as a key mechanism of resistance to KRAS inhibition in #pancreaticcancer. Combining PI3K and KRAS inhibition may help enhance therapeutic response in PDAC. aacrjournals.org/cancerres/ar...

🎉 Excited to share our new paper led by @xiangyuge.bsky.social in Cancer Research @theaacr.bsky.social! 🧬 We flip the script on the RAS/PI3K relationship: PI3K is more than a RAS effector, it is also its regulator! @yalecancer.bsky.social @yalemed.bsky.social aacrjournals.org/cancerres/ar...

At @yalecancer.bsky.social Grand Rounds, Dr. Prasanna Ananth asked, “What defines high-quality end-of-life care for children with #cancer?” and explained what we measure and how is what is most important to families with children facing #advancedcancer. ➡️ youtube.com/watch?v=4zPh...

How does diet causally influence tumor development? Fat composition — not amount — rewires the pancreatic lipidome to control ferroptosis sensitivity and tumorigenesis. Grateful to all collaborators and excited to build on this.

Muzumdar Lab@muzumdarlab.bsky.social · 4mo ago

🔔Why does high-fat diet promote #PancreaticCancer? And does the type of fat matter? Epidemiologists have asked this for decades. Our new paper in Cancer Discovery @theaacr.bsky.social shows that fat composition — not just fat quantity — governs tumorigenesis. aacrjournals.org/cancerdiscov...

New research from @muzumdarlab.bsky.social shows it’s not how much fat you eat, but the type that may drive risk of #pancreaticcancer. Some fats were found to even suppress tumors. medicine.yale.edu/news-article...

The Type of Fat—Not the Amount—Fuels Pancreatic Cancer

A new study identifies oleic acid as an unexpected driver of tumor growth and points to omega-3-rich diets as a potential prevention strategy.

medicine.yale.edu

🔔Why does high-fat diet promote #PancreaticCancer? And does the type of fat matter? Epidemiologists have asked this for decades. Our new paper in Cancer Discovery @theaacr.bsky.social shows that fat composition — not just fat quantity — governs tumorigenesis. aacrjournals.org/cancerdiscov...

New research shared by Dan McQuaid @muzumdarlab.bsky.social links #obesity-driven #pancreaticcancer to dysregulation of the hormone cholecystokinin (CCK). #AACR26 @theaacr.bsky.social @oncoalert.bsky.social

📢 New paper alert 🚨 We found that β cells are bona fide drivers of #obesity-associated #PancreaticCancer progression → targeting the #endocrine pancreas might prevent #exocrine cancer. 🔑 #CancerBiology. @yalecancer.bsky.social @yalemed.bsky.social🧵 👇🏾 www.nature.com/articles/s41...

Thanks to @lustgarten.org for its critical support of our research! @yalecancer.bsky.social

The Lustgarten Foundation@lustgarten.org · 6mo ago

New research is uncovering how pancreatic cancer begins & grows. Mandar Muzumdar, MD, funded in part through Lustgarten's Therapeutics-Focused Research Program, is studying how hormone shifts in the pancreas may drive cancer development—helping open ways to detect, prevent & treat 👉 bit.ly/40Oxaro

Hormone behind obesity-induced #pancreaticcancer discovered: “We discovered the pancreas inappropriately produces the hormone #cholecystokinin in response to obesity and was a key driver of obesity-associated pancreatic cancer in mice.”-@muzumdarlab.bsky.social medicine.yale.edu/cancer/news-...

Researchers Identify Hormone Behind Obesity-Induced Pancreatic Cancer

Yale scientists identified a hormone that initiates the development and progression of pancreatic cancer in obesity. And it’s not insulin.

medicine.yale.edu

Discovery that #obesity induces the expression of the peptide hormone cholecystokinin (CCK) in #β-cells, affecting the peri-islet acinar cells and promoting islet-proximal #tumor formation @muzumdarlab.bsky.social @krishnaswamylab.bsky.social doi.org/10.1038/s414...

Studies in mice define endocrine-exocrine beta cell-derived CCK signaling as a bona fide driver of #obesity associated PDAC development and uncover avenues to target the endocrine pancreas to subvert exocrine tumorigenesis. #pancreaticcancer www.nature.com/articles/s41...

We recently added a public track hub of "cancer effect size" across 20 TCGA cancer cohorts. Thank you to @jeffreytownsend.bsky.social and his lab at Yale University for providing the data. View it on the Genome Browser here: https://bit.ly/496Cx92.

Read our @natgenet.nature.com News&Views on the impressive work by @muzumdarlab.bsky.social and @sstevenwang.bsky.social. How does the 3D genome guide Kras-driven cancers evolution? Find out with single-cell genome-wide chromatin tracing! 📖https://rdcu.be/eShAY

Muzumdar Lab@muzumdarlab.bsky.social · last yr.

💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space. Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬. It’s the first 3D genome atlas of cancer progression. Thread 👇

A career development grant from the AACR enabled Yale Cancer's Luisa Escobar-Hoyos, MSc, PhD, to secure two major multi-year federal grants for her pancreatic cancer research: Learn more in #AACRStories: www.aacr.org/about-the-aa... #PancreaticCancerAwarenessMonth

Congrats to the newly minted Dr. Ge @xiangyuge.bsky.social for defending her thesis today! A tour de force talk on her work unraveling signaling interactions between #PI3K and #KRAS. @yalecancer.bsky.social. Check out her preprint: www.biorxiv.org/content/10.1...

A new study led by Dr. Prasanna Ananth explores how the 21st Century Cures Act—giving patients immediate access to electronic health records, impacts #cancer care in the pediatric oncology population. yalecancercenter.org/news-article...

Excited to present at the sixth annual #ConnectingTheDots symposium with @cityofhope.bsky.social. Join us Nov. 7 for a deep dive into the #diabetes-#cancer interface.

🎉PUBLISHED @natgenet.nature.com 📰Tracing the evolution of single-cell 3D genomes in Kras-driven #cancers. By Miao Liu, @muzumdarlab.bsky.social, @sstevenwang.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

Tracing the evolution of single-cell 3D genomes in Kras-driven cancers - Nature Genetics

This study uses chromatin tracing to identify alterations in single-cell 3D genome conformation during the progression of Kras-driven mouse lung adenocarcinoma and pancreatic ductal adenocarcinoma, an...

nature.com

💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space. Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬. It’s the first 3D genome atlas of cancer progression. Thread 👇

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

New @natgenet.nature.com study from @muzumdarlab.bsky.social + @sstevenwang.bsky.social maps 3D genomes in KRAS-driven lung & pancreatic #cancer, revealing stage-specific changes + potential biomarkers. ➡️ yalecancercenter.org/news-article...

Cancer's Progress Detailed by 3D Genomic Maps

Using new technology, Yale researchers examine cancer progression in single cells to visualize and understand its evolution from pre-cancerous to advanced

yalecancercenter.org

This work was done in collaboration with my @yaleschoolofmed.bsky.social colleague Professor Mandar Muzumdar @muzumdarlab.bsky.social and co-led by Drs. Miao Liu, Shengyan Jin, and Sherry Agabiti. Congrats to all authors! Also thank you National Cancer Institute for funding this work! 10/12