🚨 Paper Alert! In this new work published in @jcellsci.bsky.social we shift our focus on MTFR1L and the feedback loop linking mitochondrial fission, mitophagy and apoptosis. MTFR1L emerges as a critical coordinator of the fission and autophagy machinery. 🔗Find the paper here: doi.org/10.1242/jcs....
X-ray diffraction data were collected at @esrf.fr on various MX beamlines. Thanks to @dfg.de @uni-freiburg.de @uniklinik-fr.bsky.social @cibss.bsky.social for the funding
Christophe Wirth@chriswir.bsky.social · 8mo agoHappy to share our paper in the frame of the @sfb1453.bsky.social project that got published in @jmolbiol.bsky.social Tremendous work from @emymrikov.bsky.social and others, on how the scaffold protein PDZK1 interacts with the urate transporter URAT1. ⬇️ www.sciencedirect.com/science/arti...
Happy to share our paper in the frame of the @sfb1453.bsky.social project that got published in @jmolbiol.bsky.social Tremendous work from @emymrikov.bsky.social and others, on how the scaffold protein PDZK1 interacts with the urate transporter URAT1. ⬇️ www.sciencedirect.com/science/arti...
Molecular Determinants of Selective and High-affinity Binding of the Scaffold Protein PDZK1 to the Urate Transporter URAT1
The renal solute carrier URAT1 (SLC22A12) is essential for urate homeostasis, with loss-of-function linked to renal hypouricemia, nephrolithiasis and …
sciencedirect.com