Matching T cells to their cognate peptides presented on MHC molecules from sequence data is a key unsolved problem in computational immunology. A transformative collaboration with @quaidmorris.bsky.social. Led by Olga Lyudovyk, @levinejon.bsky.social & Melissa Pathil! 👇 @mskcancercenter.bsky.social

Quaid Morris@quaidmorris.bsky.social · 3w ago

Can we predict which T cells recognize which peptides? A lot of the signal is hiding in AlphaFold3's (AF3's) hallucinations. enFoldX: instead of one predicted structure, we use the whole noisy ensemble to predict TCR:pMHC binding. www.biorxiv.org/content/10.6... 💻 🧬 github.com/jonlevi/enFoldX

Congrats to Ichiro Taniuchi's lab! Happy to have been part of this study with Yoselin Paucar Iza showing that Runx–CBFβ complexes are essential for the development of tolerogenic Thetis cells. Overexpression of Runx enhances TC IV and pTreg differentiation. www.nature.com/articles/s41...

Runx–CBFβ regulates the development of tolerogenic Thetis cells - Nature Immunology

Taniuchi and Brown and colleagues report that the Runx–CBFβ transcription factor complex plays a crucial role in the development of intestinal RORγt+ antigen-presenting cells, which are required to pr...

nature.com

We are hiring! The Brown Lab is looking for a computational biologist to join our team. If you enjoy working with single-cell and spatial genomics data and want to study how immune cells develop and function, we’d love to hear from you! Apply here: hhmi.wd1.myworkdayjobs.com/External/job...

Bioinformatics Specialist I - Brown Lab

Primary Work Address: 1275 York Avenue, New York, NY, 10021 Current HHMI Employees, click here to apply via your Workday account. About the Lab The Brown Laboratory studies how the tissue microenviron...

hhmi.wd1.myworkdayjobs.com

By uncovering the origins of a group of rare immune cells called Thetis cells, #GilliamFellow Yoselin Paucar Iza & #FreemanHrabowski Scholar @chrysothemisbrown.bsky.social are unlocking these cells' potential to help treat — or even prevent — food allergies & autoimmune diseases: bit.ly/4cnQpii.

Very happy to share our new study defining the ontogeny of Thetis cells and the developmental cues that shape their early-life wave of differentiation. www.nature.com/articles/s41... Beautiful work led by @hhmi-science.bsky.social Gilliam Fellow Yoselin Paucar Iza and postdoc Tyler Park 1/

Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows

Summer Undergraduate Research Experience | HHMI

The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.

bit.ly

A thought-provoking and much needed review of cDC2 heterogeneity from @minuttilab.bsky.social! onlinelibrary.wiley.com/doi/10.1111/...

Ontogenetic Diversification of Type 2 Conventional Dendritic Cells in the Bone Marrow: A Central Logic for Peripheral Immunity

Type 2 conventional dendritic cells (cDC2s) are central orchestrators of adaptive immunity. While historically considered a single population shaped by local microenvironments, recent evidence indica...

onlinelibrary.wiley.com

Excited to share our review on Thetis cells and dendritic cells, and their roles in mucosal immunity and tolerance @natimmunol.nature.com rdcu.be/eLtB1

Antigen-presenting cells as arbiters of mucosal tolerance and immunity

Nature Immunology - Brown and colleagues review the heterogeneity of mucosal antigen-presenting cells that orchestrate T cell immunity to intestinal antigens.

urldefense.com

The American Association of Immunologists AAI meeting will be in Boston, April 15-19, 2026. Come join me and @chrysothemisbrown.bsky.social at this exciting Symposium on Early life immune development. Submit your abstracts by October 15th! immunology2026.aai.org/session/earl...

Early Life Immune Development and Function   - IMMUNOLOGY2026™

Time: 8:00 - 11:30 AM Chairs: Chrysothemis C. Brown, Memorial Sloan Kettering Cancer Ctr., USA Petter Brodin, Imperial Col. London and Karolinska Inst., GBR, SWE

immunology2026.aai.org

Thank you for the lovely write up! @mskcancercenter.bsky.social

Memorial Sloan Kettering Cancer Center@mskcancercenter.bsky.social · last yr.

“This is a great example of how clinical studies can reveal clues to fundamental mechanisms in biology,” says MSK's @chrysothemisbrown.bsky.social ‬. "These new understandings can pave the way for new treatment strategies for food allergies, which are desperately needed.” Learn more ⬇️

Yep...& senior author of one, @chrysothemisbrown.bsky.social, will be at www.emds2025.com in Edinburgh 🏴󠁧󠁢󠁳󠁣󠁴󠁿 in Sept. to discuss their work. So, if you're interested in RORgt+ APC, or APC more generally, EMDS2025 is for you! Abstract deadline: TODAY. @britsocimm.bsky.social @natrevimmunol.nature.com

Nature Reviews Immunology@natrevimmunol.nature.com · last yr.

Not one, not two .... but FIVE recent papers highlighting a role for RORgt+ antigen-presenting cells in the gut in establishing tolerance to food antigens #oraltolerance #immunosky #foodallergy

Excited to share our study describing a role for a subset of Thetis cells, TC IV, in tolerance to food antigens. A team effort led by Vanja Cabric and Yollanda Parisotto www.science.org/doi/10.1126/...

A wave of Thetis cells imparts tolerance to food antigens early in life

Within the intestine, peripherally-induced regulatory T (pTreg) cells play an essential role in suppressing inflammatory responses to food proteins. However, the identity of antigen-presenting cells (...

science.org

Interested in immunology and looking to gain research experience before applying to graduate or medical school?Join us! We're hiring a research technician general-mskcc.icims.com/jobs/83021/r...

Memorial Sloan Kettering Cancer Center Careers

Let’s change the way the world treats cancer Our multi-disciplinary teams work together to provide exceptional patient care, develop innovative research, and deliver outstanding educational programs.

general-mskcc.icims.com

1/ Keen to share the story of my postdoc research out in @natureportfolio.bsky.social! We built a massive resource characterizing the spatial landscape of the gut—and yes, we dug deep into the biology too. If you’ve got a minute, let me walk you through the story. 🧵👇 www.nature.com/articles/s41...

Spatially restricted immune and microbiota-driven adaptation of the gut - Nature

Intestinal regionalization is characterized by robust and resilient structural cell states and the intestine can adapt to environmental stress in a spatially controlled manner through crosstalk betwee...

nature.com