1/2 Meet the panellists for the first two recordings of season two of our podcast, A Question of Science. Book your tickets now to be part of the live studio audience at the recordings on 17 June, live at the Crick: lostintv.com/tv-show?id=1...

Thymic output in human newborns is shaped by environmental exposures and a common TCRD genetic variant. New study from Ziyang Tan, Camille Kergaravat, Antoine Toubert @upcite.bsky.social, Petter Brodin @petterbrodin.bsky.social @ki.se and colleagues: rupress.org/jhi/article/...

New, fascinating insights into thymic output in young infants: Thymic output in human newborns is shaped by environmental exposures and a common TCRD genetic variant rupress.org/jhi/article/...

Thymic output in human newborns is shaped by environmental exposures and a common TCRD genetic variant

Longitudinal profiling of 136 newborns shows thymic output peaks at 3–4 mo, correlating with plasma RANKL, lymphotoxin-α, and the TCRD variant rs2204985. I

rupress.org

Thanks for highlighting!

Rockefeller University Press@rupress.org · 5mo ago

In a new study @jhumimmunity.org from Tan, Kergaravat, @petterbrodin.bsky.social et al., longitudinal profiling of 136 newborns shows thymic output peaks at 3–4 mo, correlating with plasma RANKL, lymphotoxin-α, and the TCRD variant rs2204985. rupress.org/jhi/article/...

Thanks Payal! It was lovely indeed!

Payal Yokota@payalyokota.bsky.social · 6mo ago

Incredible day at #AAI2026 today with brilliant talks and warmth of seeing old and new friends. First, smashing talks by @petterbrodin.bsky.social and @chrysothemisbrown.bsky.social this morning in #EarlylifeImm major symposia. Great discussions and wonderful data

New paper📢 - how many individuals are affected by an autoimmune disease. Together with epidemiology experts jonas Ludvigsson @ki.se we use 🇸🇪 population registry and find that 1/13 adults and 1/67 children are affected by autoimmunity: link.springer.com/article/10.1...

Incidence and prevalence of autoimmune disease in the Swedish National Patient Register - European Journal of Epidemiology

European Journal of Epidemiology - Standardized definitions of autoimmune disease (AD) are lacking. Therefore, we aim to propose a definition of AD for register-based research and estimate the...

link.springer.com

Expanding the scope of human immunology in the Journal of Human Immunity. New Editorial from Petter Brodin @petterbrodin.bsky.social, Megan Cooper @macattacklab.bsky.social, Jean-Laurent Casanova @casanovalab.bsky.social, and colleagues in the JHI Editorial team:

Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field www.annualreviews.org/content/jour...

Tissue Regulatory T Cells

FOXP3+ regulatory T cells (Tregs) have well-defined roles in limiting systemic immune responses against diverse stimuli. However, the observation that a subset of Tregs also enter nonlymphoid tissues,...

annualreviews.org

Paper alert 📢: What drives variation in humoral responses to viruses? collab with @etienne-patin.bsky.social @darraghduffy.bsky.social @lquintanamurci.bsky.social we show that for ~98k viral epitopes immunodominance vary by genetics, sex and origin: www.nature.com/articles/s41...

Expanding the scope of human immunology in the JHI. In this Editorial, @petterbrodin.bsky.social, @macattacklab.bsky.social, @casanovalab.bsky.social, alongside JHI's Associate, Consulting, as well as Society Editors, outline a broader scope for the journal. rupress.org/jhi/article/...

Available to read now via #OpenAccess pubs.rsc.org/en/content/a... @ki.se @petterbrodin.bsky.social

Gut health monitoring via intestinal barrier function screening using a transepidermal microneedle-based sensor

The growing prevalence of chronic digestive disorders, such as inflammatory bowel disease, underscores the urgent need for innovative solutions that enable longitudinal monitoring of disease progressi...

pubs.rsc.org

valebodi.bsky.social@valebodi.bsky.social · 9mo ago

Gut health monitoring via intestinal barrier function screening using a transepidermal microneedle-based sensor (2026) Nicolas Maïno, Sihui Xuad, Petter Brodin and Onur Parlak @petterbrodin.bsky.social

Gut health monitoring via intestinal barrier function screening using a transepidermal microneedle-based sensor (2026) Nicolas Maïno, Sihui Xuad, Petter Brodin and Onur Parlak @petterbrodin.bsky.social

🎉Congratulations to @wiebkearlt.bsky.social, @petterbrodin.bsky.social and @borislenhard.bsky.social for being named on Clarivate's list of Highly Cited Researchers for 2025! This list celebrates influential academics whose work has made a profound impact on their field!

Three LMS researchers named among most influential in the world in 2025

Professors Wiebke Arlt, Petter Brodin and Boris Lenhard, who lead groups at the MRC Laboratory of Medical Sciences (LMS), have been included on the prestigious Highly Cited Researchers 2025 list.

lms.mrc.ac.uk

Me and a few leading colleagues discuss female-specific immune systems in health and disease. By @starrevartan.bsky.social in @newscientist.com www.newscientist.com/article/2501...

Women have supercharged immune systems and we now know why

Being born with two X chromosomes brings a host of health benefits, and recognising this could lead to personalised medical treatments for men and women

newscientist.com

Recap 2023 via @petterbrodin.bsky.social @theguardian.com www.theguardian.com/science/2023... The term “immunity debt” was first introduced by French researchers in 2021. It refers to a population-wide effect rather than an individual-level one.

Immunity debt: does it really exist?

Some claim the rise in winter infections has been caused by the reduction of seasonal bugs during lockdowns. But experts are sceptical about these oversimplified explanations

theguardian.com

Why are more and more people suffering from #allergies and autoimmune diseases? The answer may lie in the development of the immune system in newborns @petterbrodin.bsky.social @ki.se has developed a technique to map #immunesystem development from a single drop of blood. tinyurl.com/3j22dyw8

How the immune system develops in newborn babies | Knut and Alice Wallenberg Foundation

Why are more and more people suffering from allergies and autoimmune diseases? The answer may lie in the development of the immune system in newborns. Wallenberg Scholar Petter Brodin has developed a ...

tinyurl.com

In new review @jhumimmunity.org, Andreakos et al. report the progress of the COVID Human Genetic Effort since its launch 5 years ago, with the aim to understand clinical variability, from resistance to severe outcomes, among individuals exposed to #SARSCoV2. rupress.org/jhi/article/...

Hehe, Thanks Grant!

Grant Schulert, MD, PhD@grantschulert.bsky.social · 11mo ago

Great to see my friend @petterbrodin.bsky.social at #ACR25 and hear about his work on hormones, chromosomes, and autoimmunity in this aptly named session

The seven enigmas of #SARSCoV2: From the past to the future. New review from Evangelos Andreakos, Helen Su, Jean-Laurent Casanova (@casanovalab.bsky.social) and colleagues: rupress.org/jhi/article/... #InbornErrorsOfImmunity #InfectiousDiseases #PopulationGenetics

The American Association of Immunologists AAI meeting will be in Boston, April 15-19, 2026. Come join me and @chrysothemisbrown.bsky.social at this exciting Symposium on Early life immune development. Submit your abstracts by October 15th! immunology2026.aai.org/session/earl...

Early Life Immune Development and Function   - IMMUNOLOGY2026™

Time: 8:00 - 11:30 AM Chairs: Chrysothemis C. Brown, Memorial Sloan Kettering Cancer Ctr., USA Petter Brodin, Imperial Col. London and Karolinska Inst., GBR, SWE

immunology2026.aai.org

#Medsky🧪 #IDsky #immunosky #publichealth @petterbrodin.bsky.social , @casanovalab.bsky.social et al To determine the underlying genetic causes & other modifying factors like sex hormones , interferon responses impacting restrained #Tcell responses to #SARSCoV2 & #viralpersistence in #LongCOVID.

Thx for highlighting @sun-in-winter12.bsky.social

Christy Collins@sun-in-winter12.bsky.social · last yr.

Hey everyone, ICYMI I wanted to highlight this groundbreaking #LongCOVID preprint. Personally, I've found there may be a lot of truth to this idea: **High anti-spike antibodies that don’t wane 6 months after infection may be a sign of viral persistence** 1/ 👇 www.medrxiv.org/content/10.1...

Variation in the human immune system is largely driven by non-heritable influences @petterbrodin.bsky.social P. Brodin et al. Cell. 2015.

Variation in the human immune system is largely driven by non-heritable influences - PubMed

There is considerable heterogeneity in immunological parameters between individuals, but its sources are largely unknown. To assess the relative contribution of heritable versus non-heritable factors,...

pubmed.ncbi.nlm.nih.gov

Weight loss improves health but What happens to cells in the fat during weight loss? Intriguingly, immune cell numbers decrease but their activated states persist w chronic inflammatory potential. Beautiful work from neighbors @mrc-lms.bsky.social Will Scott et al www.nature.com/articles/s41...

Selective remodelling of the adipose niche in obesity and weight loss - Nature

An atlas study of adipose tissue in people with obesity undergoing weight loss and their lean counterparts reveals that weight loss reduces cell senescence but cannot reverse all the metabolic problem...

nature.com

New paper 📣! Pixelgen reports its incredible new Proximity Network Assay (PNA)->3D maps of 155 proteins in single cells by sequencing by barcoded antibodies and in situ rolling circle amplification yields >40,000 spatial nodes/cell: www.biorxiv.org/content/10.1...

No evidence for neutralizing IL1RN autoantibodies in our cohorts of MIS-C, SARS-CoV2 pneumonia or vaccine-induced myocarditis. onlinelibrary.wiley.com/doi/10.1111/... Great work by Anish Behere in Nils Landegren lab, Uppsala university

Evaluating IL1RA‐Autoantibodies Across SARS‐CoV‐2‐Related Diseases

Click on the article title to read more.

onlinelibrary.wiley.com

Exciting new cell state model from @arcinstitute.org

Arc Institute@arcinstitute.org · last yr.

Introducing Arc Institute’s first virtual cell model: STATE

Absolute pleasure to be teaching human systems immunology @efis-immunology.bsky.social summer school in beautiful Alghero, Sardinia.

"Children should be included in ongoing and future clinical trials for Long Covid Age-related protections & regulations must be incorporated, including obtaining institutional review board/research ethics approval along with paediatric assent & parental publications.ersnet.org/content/erj/...

Reminder to join us June 5/6 in Paris if you're interested in pediatric immunity and cancer development ! @institutcurie.bsky.social @gustaveroussy.fr @hopitalnecker.bsky.social @institutimagine.bsky.social

Josh Waterfall@joshwaterfall.bsky.social · 2y ago

Interested in the relationship between the developing immune system and pediatric cancer ? Come join us for the first Paris Kids Cancer symposium June 5/6 institut-curie.org/symposium-pa... @institutcurie.bsky.social @aphp.bsky.social @gustaveroussy.fr @institutimagine.bsky.social