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Chris van Dorp

@chvandorp.bsky.social

Associate Research Scientist at Columbia University Irving Medical Center, dept of Pathology and Cell Biology.

12 Posts27 Follower47 Folgt
Chris van Dorp@chvandorp.bsky.social · last wk.

Our paper on SARS-CoV-2 school-related measures prior to vaccination in Portugal has just been published in @commsmed.nature.com Thanks to Benedetta and Rey for all the hard work! www.nature.com/articles/s43...

Retrospective evaluation of school-related measures on pre-vaccination transmission dynamics of SARS-CoV-2 - Communications Medicine

Canfora, Escosio, et al. use an age-stratified transmission model fitted to Portuguese COVID-19 hospitalization and seroprevalence data to assess the impact of school closures before mass vaccination....

nature.com

Chris van Dorp@chvandorp.bsky.social · last mo.

Our preprint about optimal vaccination, increasing life expectancy, age-dependent mortality, and waning of immunity is now available on MedRxiv. Thanks to @mvboven.bsky.social for inviting me to contribute. We use a PDE model in Julia to game out different scenarios. www.medrxiv.org/content/10.6...

Optimal vaccination in aging populations under age-dependent infection fatality risks

Background Vaccination programs have greatly reduced the burden of infectious diseases, particularly in childhood. As populations age, however, the burden of respiratory infections such as influenza A...

medrxiv.org

Chris van Dorp@chvandorp.bsky.social · 2mo ago

Congratulations to Tina Roostaei, Hanane Touil, Phil de Jager and all other co-authors with the publication of this paper on T cell and monocyte dysregulation in MS: www.cell.com/cell-reports... I'm honored to have made a modest contribution!

Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis

Roostaei et al. define cell-type- and state-specific transcriptional programs associated with immune dysregulation in multiple sclerosis. Integrating purified immune cell transcriptomics, network anal...

cell.com

Chris van Dorp@chvandorp.bsky.social · 12mo ago

Our TRM modeling paper is now published in PLOS Computational Biology! In this paper, we fit dynamical (ODE) models to single-cell flow cytometry data using a variational autoencoder that has a GMM with time-dependent weights as prior. journals.plos.org/ploscompbiol...

A variational deep-learning approach to modeling memory T cell dynamics

Author summary After an influenza infection, antibodies provide strong protection—but only against the same strain. Because influenza rapidly mutates its surface proteins, this protection soon becomes...

journals.plos.org

Chris van Dorp@chvandorp.bsky.social · last yr.

Our manuscript on the effect of school closure on pre-vaccination SARS-CoV-2 transmission is now available on MedRxiv. Congrats to first authors Benedetta and Rey! www.medrxiv.org/content/10.1...

Retrospective evaluation of school-related measures on pre-vaccination transmission dynamics of SARS-CoV-2

Schools are important settings for respiratory virus transmission and a major focus of pandemic control measures in the absence of effective pharmaceutical interventions. During the COVID-19 pandemic,...

medrxiv.org

Bram van Dijk 🏳️‍🌈@bramvandijk.bsky.social · last yr.

Nearly 20 years ago, theory predicted that evolution can evolve “mutation sensors” to improve evolvability. Michael Barnett et all et al. now show this in a beautiful experiment! ❤️ www.science.org/doi/10.1126/...

Experimental evolution of evolvability

Evolvability—the capacity to generate adaptive variation—is a trait that can itself evolve through natural selection. However, the idea that mutation can become biased toward adaptive outcomes remains...

science.org

Chris van Dorp@chvandorp.bsky.social · last yr.

In this preprint we quantify how resident-memory CD4 T cells are maintained in skin and lamina propria, and where they come from. We did this with a fate reporter mouse model, and of course Bayesian ODE models implemented in Stan. doi.org/10.1101/2024...

Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and replacement from precursors

Tissue-resident memory T cells (TRM) protect from repeated infections within organs and barrier sites. The breadth and duration of such protection is defined at minimum by three quantities; the rate a...

doi.org

Chris van Dorp@chvandorp.bsky.social · 2y ago

Our CD4 memory T cell paper is finally published in PLOS Biology (doi.org/10.1371/jour...). Congratulations to Elise Bullock and other co-authors!

The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host

The quality and longevity of CD4+ effector and central memory T cells change with age in mice. This study shows that these cells have longer lifespans and become more quiescent when the organism ages,...

doi.org

Chris van Dorp@chvandorp.bsky.social · 3y ago

My first publication of 2024! Thanks to Michiel van Boven and all other co-authors. This work required some creative Stan programming. doi.org/10.1371/jour...

Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study

Author summary Households are a main setting for transmission of respiratory viruses. Here, we analyse data from a prospective household study to estimate the time-dependent hazards of introduction of...

doi.org