Happy season break from our lab! ♥️ @ameachasag.bsky.social @pedrandrei.bsky.social @emmataggart.bsky.social
Francesca Ciccarelli
@ciccarellilab.bsky.social
We study the drivers of cancer evolution from initiation to response to therapy. We are part of the Centre for Cancer Evolution at Barts Cancer Institute and the Francis Crick Institute in London, UK. Posts from Francesca
Enjoying my time @theaacr.bsky.social KCA joint conference on Cancer Precision Medicine in beautiful Busan, Korea
First time I give a talk literally in a football stadium 😎⚽️
Our first Centre for Cancer Evolution PI retreat! A wonderful day at Goodenough House discussing science, strategy and forging new collaborations @qmbci.bsky.social
Great science and good fun at the faculty retreat of the Centre for Cancer Evolution @qmbci.bsky.social. Here @stuartmcdonald.bsky.social explaining his big question!
This is an important milestone: mutagenic drugs can increase TMB and induce a dMMR-like genetic profile, but do not improve response to immunotherapy in pMMR CRC patients. Some evidence of TIME remodelling, but likely not in the direction needed fro response... www.sciencedirect.com/science/arti...
Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer
Mismatch repair deficient (MMRd) tumors harbor thousands of somatic mutations enriched for insertion–deletion (indels) conferring high sensitivity to …
sciencedirect.com
Great meeting and great questions! Thanks for inviting me!
Cancer Research UK Scotland Institute@cruk-si.bsky.social · last yr.Francesca Ciccarelli @ciccarellilab.bsky.social is up next to tell us about spatial drivers of response to immunotherapy in colon cancer Thank you to TransnetYX for sponsoring Francesca’s talk! @qmbci.bsky.social | @crick.ac.uk | @cruk-cityoflondon.bsky.social | #BICC2025
Our very own @mirjana-efremova.bsky.social (very small compared to the very huge screen) speaking about her beautiful data on cell plasticity in cancer mets at the #Beatson International Cancer Conference. @qmbci.bsky.social @cruk-mi.bsky.social
La Caixa panel dinners are always a treat! View of Barcelona from the museum of Catalan art
I spent two days meeting students and faculty & delivering the keynote speech at the London Health Research Day @westernu.bsky.social. I truly enjoyed the enthusiasm and genuine engagements of the young generation of cancer researchers! Thanks @ggloor.bsky.social & colleagues for inviting me!
Familiar faces in Belfast! Enjoyable time at the meeting of the Irish Association for Cancer Research! @qmbci.bsky.social
Next Thu 13th March Ilaria Malanchi @ila07.bsky.social and I will host the next "Medicine at the Crick" event focusing on how tissues evolve over time and why this may initiate disease. Free in person/virtual registration @crick.ac.uk: www.eventbrite.co.uk/e/medicine-a...
Dear Volodymyr Zelenskyy, dear Ukrainian friends, you are not alone.
We have two open positions for #computationalbiologists to work on: 1. Early cancer initiation following our work in #NatureCancer (Ref 5028) 2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073) To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...
Very timely publication on World Cancer Day and spot on title considering the times we live in. I am very proud of all wonderful colleagues that dedicate their talent to understand, treat and eventually cure cancer @qmbci.bsky.social 💪💪💪
Barts Cancer Institute (Queen Mary University of London)@qmbci.bsky.social · last yr.📖 Today on World Cancer Day, we're delighted to publish a special book celebrating two decades of cancer discoveries since the establishment of the BCI @qmul.ac.uk 🎉 #worldcancerday #WCD2025 #medsky 🧪 @qmulfmd.bsky.social @cruk-cityoflondon.bsky.social www.bci.qmul.ac.uk/general-news...
Really enjoyed @mirjana-efremova.bsky.social talk on phenotypic plasticity in #ColorectalCancer Super clear explanation of role of key genes ( #LRIG1 etc) in cell switch @qmbci.bsky.social @ciccarellilab.bsky.social @drtanyasoliman.bsky.social @mcclellandlab.bsky.social @sibucz.bsky.social
Cool to be at #FoG2025 @fogenomics.bsky.social A bit more #SpatialGenomics content this year which is great! Surprise visit from #Darth & #Chewbacca! @ciccarellilab.bsky.social @mirjana-efremova.bsky.social @karlsmithbyrne.bsky.social @qmbci.bsky.social @omaiques.bsky.social
Great talk from Hrvoje Misetic on the context dependent role of Cdkn2a in cancer evolution @qmbci.bsky.social @cruk-cityoflondon.bsk.social. Well done 👏💪👌
Nathaniel MonPere from @benjaminwerner.bsky.social lab in the Centre for Cancer Evolution @qmbci.bsky.social modelling #clonalhaematopoiesis in ageig at the Annual Symposium of @cruk-cityoflondon.bsky.social
With Ilaria Malanchi @ila07.bsky.social we will host the #MedicineattheCrick event (13th March at the Crick @crick.ac.uk.) Join world experts to discuss how early mutant cells interact with surrounding niche to maintain homeostasis or start cancer. Free registration! Details in the poster 👇
Strong Barts representation at the Cancer Research Nottingham Annual Symposium! @francesbalkwill.bsky.social @qmbci.bsky.social @uniofnottingham.bsky.social
Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert). Looking forward to working with you!
New paper from our lab just out in @cp-cancercell.bsky.social! Integrating spatial omics, cell co-cultures and staining of clinical trial samples, we show that CD74 marks the right local microenvironment for #immunotherapy response. Excitingly, this may increase the number of treatable patients!
A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer
Fewer than 50% of metastatic deficient mismatch repair (dMMR) colorectal cancer (CRC) patients respond to immune checkpoint inhibition (ICI). Identify…
sciencedirect.com