What happens when nanobodies developed against a molecular chaperone turn out to selectively inhibit different steps in Tau aggregation? You get chaperone-inspired nanobodies 🧠 In our paper out in Comms Biol @natureportfolio.nature.com we explore this surprising finding doi.org/10.1038/s420...

Amyloid-beta precursor protein (APP) is a complicated protein with many functions. A corrupted form can destroy nerve cells, leading to the loss of thought and memory in Alzheimer's disease. #WorldAlzheimersDay

PDB101: Molecule of the Month: Amyloid-beta Precursor Protein

Cell-clogging amyloids form when proteins improperly aggregate

pdb101.rcsb.org

A strand of RNA has been discovered to perform two key reactions required for self-replication. The molecule offers a clue towards understanding the origin of life, namely how non-living chemistry on prebiotic Earth started to self-replicate and evolve.

Self-synthesising RNA strand offers clues to life’s origins

RNA strand, made of just 45 nucleotides, performs two key reactions required for self-replication

chemistryworld.com

The production and accumulation of aberrant proteins can have serious pathological consequences. In a new #ScienceReview, researchers explore how organisms maintain the extracellular proteome. https://scim.ag/4tdEB7B

Systems-level organization of extracellular proteostasis

One defining feature of complex organisms is the ability to maintain protein homeostasis beyond cellular boundaries. We review how extracellular proteostasis is organized as a hierarchical network spa...

scim.ag

Good morning!! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Systems-level organization of extracellular proteostasis www.science.org/doi/10.1126/...

New in @science.org: our #ScienceReview explores how protein homeostasis is maintained beyond cellular boundaries proposing #extracellular #proteostasis as a hierarchical network spanning pericellular, tissue, and systemic tiers. With Michele Vendruscolo 📄 Read here www.science.org/doi/10.1126/...

Systems-level organization of extracellular proteostasis

One defining feature of complex organisms is the ability to maintain protein homeostasis beyond cellular boundaries. We review how extracellular proteostasis is organized as a hierarchical network spa...

science.org

Join us next Friday 11:30 for Pietro's Sormanni seminar at @cienciasulisboa.bsky.social | ciencias.ulisboa.pt/en/node/17783

📣 In Alzheimer’s disease neurons respond to toxic Aβ oligomers by boosting S100B — a Ca-binding chaperone that protects the cytoskeleton and synapses from damage 🧠Collaboration with the Cardoso Lab, spearheaded by our joint PhD student Joana Saavedra 👩‍🔬👏 📄https://doi.org/10.3389/fnmol.2025.1636365

Frontiers | Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by the intracellular deposition of Tau protein and extracellular deposition of...

doi.org

Design of intrinsically disordered region binding proteins | Science www.science.org/doi/10.1126/...

Design of intrinsically disordered region binding proteins

Intrinsically disordered proteins and peptides play key roles in biology, but a lack of defined structures and high variability in sequence and conformational preferences have made targeting such syst...

science.org

The second day of talks at #ISPIS2025 #Lisbon finishes with one of our hosts, @claudiogomeslab.bsky.social, telling us about extracellular proteostasis, and the role of S100B as a chaperone holdase in biology and disease

Cláudio Gomes Lab - Protein Misfolding in Disease@claudiogomeslab.bsky.social · last yr.

International Symposium on Protein Interactions and self assembly 🇵🇹 📣 Day 2 quick off with @lindorfflarsen.bsky.social talk on Predicting condensates of disordered proteins and many others to follow, poster pitches and session and lakeside lunch. #ISPIS2025 #Lisbon @cienciasulisboa.bsky.social

International Symposium on Protein Interactions and self assembly 🇵🇹 📣 Day 2 quick off with @lindorfflarsen.bsky.social talk on Predicting condensates of disordered proteins and many others to follow, poster pitches and session and lakeside lunch. #ISPIS2025 #Lisbon @cienciasulisboa.bsky.social

All set for the start of the 'International Symposium on Protein interactions and self assembly' in Lisbon 🇵🇹 later today. Excited to host an amazing lineup of speakers and 65 participants from all over during the next 3 days #ISPIS2025 @twin2pipsa @cienciasulisboa.bsky.social #ULisboa

Cláudio Gomes Lab - Protein Misfolding in Disease@claudiogomeslab.bsky.social · last yr.

📢 International Symposium on Protein Interactions and Self-Assembly Join us in ☀️ Lisbon 🇵🇹 🗓️ 14–16 July 2025 🗣️ A great programme + short talks selected from abstracts. 🔗 Check it here: twin2pipsa.campus.ciencias.ulisboa.pt/ISPIS2025.html 🔬 Powered by #TWIN2PIPSA at @cienciasulisboa.bsky.social

Received the 2025 ULisboa/CGD Award in Biomedical Sciences yesterday! 🧪🧠🥼 Thank you to my incredible team and collaborators — and congrats to all fellow awardees!👏

CIÊNCIAS ULisboa@cienciasulisboa.bsky.social · last yr.

Prémios Científicos Universidade de Lisboa / Caixa Geral de Depósitos 2025. 🔗Leia aqui a notícia e conheça melhor os 10 professores e investigadores de Ciências distinguidos com Prémios e Menções Honrosas: t.ly/SwpM7 🎖Parabéns a todos!

Still time to submit an abstract for a short talk! Join us in Lisbon to discuss all things protein — interactions, aggregation, phase separation, and more! 🗓️ Deadline 30 June

Cláudio Gomes Lab - Protein Misfolding in Disease@claudiogomeslab.bsky.social · last yr.

📢 International Symposium on Protein Interactions and Self-Assembly Join us in ☀️ Lisbon 🇵🇹 🗓️ 14–16 July 2025 🗣️ A great programme + short talks selected from abstracts. 🔗 Check it here: twin2pipsa.campus.ciencias.ulisboa.pt/ISPIS2025.html 🔬 Powered by #TWIN2PIPSA at @cienciasulisboa.bsky.social

📢 International Symposium on Protein Interactions and Self-Assembly Join us in ☀️ Lisbon 🇵🇹 🗓️ 14–16 July 2025 🗣️ A great programme + short talks selected from abstracts. 🔗 Check it here: twin2pipsa.campus.ciencias.ulisboa.pt/ISPIS2025.html 🔬 Powered by #TWIN2PIPSA at @cienciasulisboa.bsky.social

Just out! A collaboration with the Herrera lab shows that S100B acts as a chaperone supporting intermediate filament organization, compensating for sacsin loss in a cell model of Autosomal Recessive Spastic Ataxia of Charlevoix–Saguenay (ARSACS) #molecularneurobiology doi.org/10.1007/s120...

S100B Mitigates Cytoskeletal and Mitochondrial Alterations in a Glial Cell Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay - Molecular Neurobiology

Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is an early-onset neurological disorder caused by mutations in the SACS gene, resulting in the loss of sacsin function. Sacsin is a m...

doi.org

Congratulations to Guilherme Moreira for the brilliant defence of his PhD thesis: “The calcium-binding protein S100B as a novel chaperone preventing Tau aggregation in Alzheimer’s disease” 🧠 Huge thanks to the jury and everyone who came to support! #ProudSupervisor @cienciasulisboa.bsky.social

A new protein sequencing method, which uses a biological motor to pull a protein through a tiny nanopore, could revolutionise protein analysis. www.chemistryworld.c...

Nanopore sequencing set to transform our understanding of proteins

Rapid sequencing technique can not only deal with proteins hundreds of amino acids long but can detect modifications

chemistryworld.com

Thrilled to be an invited speaker 🗣️ at the @acs.org Fall 2025 Global Virtual Symposium "Tackling Multifactorial #Alzheimer’s Disease"🧠 .Join us as we explore the latest advances in understanding the complex nature of AD. 📆 Submit your abstract by 31/3/24 🧪 www.acs.org/events/fall/...

Progress in Understanding and Tackling Multifactorial Alzheimer’s Disease - American Chemical Society

A virtual symposium of ACS Fall 2025 programmed at convenient day times of multiple regions. This Global Virtual Symposia aims to discuss these recent developments comprehensively, enhancing our unde...

acs.org

Our paper on prediction of phase-separation propensities of disordered proteins from sequence is now published: www.pnas.org/doi/10.1073/... The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n

Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions

Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions

Schmid and Walter train a classifier that discerns functionally relevant structure predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer, and they use this confidence metric to curate a database of 40,000 predicted interactions among ∼300 genome maintenance proteins.

dlvr.it

Looking forward #ADAM10 kick-off 🇸🇪 3 days of all things amyloid and great opportunity to meet old friends and making new ones! Thanks @professorpernilla.bsky.social and Elin Esbjorner et al for such a great program. Reach out if you are around www.chalmers.se/en/conferenc...

Hello Bluesky, we just landed and are happy to reconnect! We research on #proteins and mechanisms of aggregation in #Alzheimer's Disease and #ProteinFolding disorders at ULisboa 🧪 Follow us for news and updates on lab life and achievements 🥼 and check us out at: 🔗 folding.campus.ciencias.ulisboa.pt