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Viny Lab

@cohesinlab.bsky.social

25 Posts104 Follower210 Folgt
@thedoctorisvin.bsky.social · 3mo ago

Great write-up from @columbiacancer.bsky.social "A cellular wrong turn in blood cancer” on our paper from @cohesinlab.bsky.social published in @bloodjournal.bsky.social . 🔑Key point: STAG2 doesn’t change how much GATA1 there is—it changes where it can act. www.cancer.columbia.edu/news/cellula...

A cellular wrong turn in blood cancer

A new study reveals how disrupted DNA navigation leads to impaired red blood cell development in myelodysplastic syndrome

cancer.columbia.edu

Viny Lab@cohesinlab.bsky.social · 3mo ago

Transcription factors don’t fail in MDS—they’re misdirected. Today in Blood, we show how loss of STAG2 rewires chromatin accessibility to redirect GATA1 and alter blood cell fate. ashpublications.org/blood/articl...

Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome

Key Points. Stag2 reprograms Gata1 cistrome specificity via chromatin accessibility, a key determinant of transcription factor lineage discrimination.Loss

ashpublications.org

Viny Lab@cohesinlab.bsky.social · 11mo ago

🚨 Excited to share our new preprint: Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome. This work was led by Columbia VP&S MD student Varun Sudunagunta (‼️ Program Directors: Varun is applying to IM residencies this year!) www.biorxiv.org/content/10.1...

Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome

The transcription factor GATA1 has pleiotropic hematopoietic functions, particularly in erythroid and megakaryocytic ontogeny. While mechanistic investigations have uncovered many facets of GATA1 biol...

biorxiv.org