Great write-up from @columbiacancer.bsky.social "A cellular wrong turn in blood cancer” on our paper from @cohesinlab.bsky.social published in @bloodjournal.bsky.social . 🔑Key point: STAG2 doesn’t change how much GATA1 there is—it changes where it can act. www.cancer.columbia.edu/news/cellula...

A cellular wrong turn in blood cancer

A new study reveals how disrupted DNA navigation leads to impaired red blood cell development in myelodysplastic syndrome

cancer.columbia.edu

🚨 Paper Alert! 🚨 @bloodjournals.hematology.org Hot off the press and presented this morning at #Myeloid2026 @columbiacancer.bsky.social @columbiamed.bsky.social Congratulations to Varun and the @cohesinlab.bsky.social team! 🎉

Viny Lab@cohesinlab.bsky.social · 3mo ago

Transcription factors don’t fail in MDS—they’re misdirected. Today in Blood, we show how loss of STAG2 rewires chromatin accessibility to redirect GATA1 and alter blood cell fate. ashpublications.org/blood/articl...

Thanks @cancerdynamics.bsky.social for highlighting this interview with @columbiacancer.bsky.social for Blood Cancer Awareness Month and our work in @cohesinlab

Irving Institute for Cancer Dynamics@cancerdynamics.bsky.social · 11mo ago

This #BloodCancerAwarenessMonth, Dr. Aaron Viny (@thedoctorisvin.bsky.social) is shining a light on the lifesaving role of transplants in blood cancers & addressing some of the most persistent myths surrounding donation via @columbiacancer.bsky.social. www.cancer.columbia.edu/news/breakin...

🚨 Excited to share our new preprint: Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome. This work was led by Columbia VP&S MD student Varun Sudunagunta (‼️ Program Directors: Varun is applying to IM residencies this year!) www.biorxiv.org/content/10.1...

Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome

The transcription factor GATA1 has pleiotropic hematopoietic functions, particularly in erythroid and megakaryocytic ontogeny. While mechanistic investigations have uncovered many facets of GATA1 biol...

biorxiv.org

Educational Session: “Dysregulation of nuclear topology in cancer: Clinical implications and emerging mechanisms” Presenter: @thedoctorisvin.bsky.social April 25, 2025, 3:30 PM - 3:50 PM CST/ 4:30 PM - 4:50 PM EST

If you’re at @theaacr.bsky.social don’t miss today’s session on 3D Topology & Cancer featuring giants of the field: Jane Skok @nyulangone.bsky.social & Brad Cairns @utah.edu Imposter syndrome at an all time high! 😬 Proud to represent @cohesinlab.bsky.social @columbiacancer.bsky.social #AACR25

Hey! Check out @drjanexu.bsky.social discussing @cohesinlab.bsky.social’s first preprint on @isehsociety.bsky.social simply blood preprint watch! www.simplyblood.org/2025/04/prep...

Preprint Watch: April

Welcome to our monthly Preprint Watch, where we highlight some of the most relevant preprints for the ISEH community! This month we cover so...

simplyblood.org

👇👇 Check out our first pre-print!

Jane Xu, PhD@drjanexu.bsky.social · last yr.

My very first post on 🦋. 1. Do you know that cohesin ring controls how transcription factor (TF) access chromatin? Excited to share my first piece of postdoctoral work where we investigate how Stag2 cohesin contributes to leukemia! 1/10. www.biorxiv.org/content/10.1....