Excited our ratiometric transcriptional activation (RTA) work led by postdoc Dr. Melissa Gray is out online today in Cell @cp-cell.bsky.social! Measurements determine what we can discover in biology; we use RTA to turn protein abundance changes into amplified signals in live cells.

Ratiometric transcriptional activation by protein degradation

By tethering a protein of interest to anti-CRISPR, protein degradation is transformed into amplified and programmable transcriptional outputs via Cas-based transcription factors, with sensitivity to p...

cell.com

Excited to share our latest work, online today at Cell Chemical Biology, in which we determine the structure of the TRIM21-NPC molecular glue ternary complex to establish the molecular basis for nuclear pore destruction by an E3 ligase: doi.org/10.1016/j.ch...

Great piece on @corsello.bsky.social and coworkers’ exciting new discovery @stanfordmedicine.bsky.social

Damon Runyon Cancer Research Foundation@damonrunyon.org · 6mo ago

Damon Runyon Clinical Investigator Steven M. Corsello, MD, and his colleagues at Stanford have discovered a drug that can degrade nuclear pores—the passageways by which mRNA leaves the nucleus—in cancer cells, effectively inducing cell death. Read more: https://bit.ly/3NCJeZJ

Great 💎s on GI cancers at #CCRTP25 @stanford-cancer.bsky.social @corsello.bsky.social -drug discovery w better yield from unexpected hits, then subsequently modified -negative results so important to publish -environmental factors like weight most likely culprits of young onset colon cancer

Excited to share our discovery of potent TRIM21 molecular glues with anticancer activity, online today @CD_AACR: "Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex". 1/18

@stanfordmedicine.bsky.social

Good morning Monterey 🌞 Nothing like multidisciplinary discussion of GI cancers to kick off another sunny morning next to the Pacific with Lipika Goyal and Pam Basto @stanford-cancer.bsky.social reviewing 8(!!) new approvals for GI cancers 🌊 Great meeting @ ANCO branch of @ascocancer.bsky.social 🤓

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

@pollyfordyce.bsky.social @stanford-chemh.bsky.social is officially a household name. That is some real impact!

Stanford Hematology has launched a physician scientist search! Research program can be lab-based and/or translational. facultypositions.stanford.edu/en-us/job/49...

Checking out the science community on Bluesky!