Cool germinal center acrobatics from Juhee Pae et al, check it out! www.nature.com/articles/s41...

This pair of papers demonstrating strong and systemic immune responses to skin commensals applied topically to unbroken skin, including induction of B cells for vaccination. www.nature.com/articles/s41... www.nature.com/articles/s41...

These are my favorites too! 🤯

What an amazing story that was such a blast to collaborate on with @mfgrp.bsky.social lab!!! Phenomenal work led by @djenetbousbaine.bsky.social and all co-authors!! Unroll this thread and be amazed 🤯👇🏾

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose. @mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com t.co/xXXCJx5VYm #ImmunoSky 🧪

A typical project for an incoming graduate student might involve 1–2 weeks of planning and 2–5 years of execution, [yet] the problem you choose will influence the impact of your work just as much as the quality of your execution. @mfgrp.bsky.social open.spotify.com/episode/6KMh...

Insanely creative and original immunology and bioengineering work from the Fischbach Lab at Stanford with high translational potential Full article in NATURE: www.nature.com/articles/s41... Follow the scientists: @mfgrp.bsky.social @djenetbousbaine.bsky.social @katebauman.bsky.social

Stanford Scientists Transform Ubiquitous Skin Bacterium into a Topical Vaccine Against Tetanus

Even better, it’s cheap, entirely pain-free, no need to stand in a line, and not followed by fever, swelling, redness, or a sore arm.

goodnewsnetwork.org

Beautiful work with exciting implications for topical vaccination by @mfgrp.bsky.social ✨ Give this a read 👇

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Vaccines, but make it skincare!🧴🧬 Congratulations to Stanford BioE Professor Michael Fischbach @mfgrp.bsky.social & @djenetbousbaine.bsky.social for engineering a skin bacterium that could lead to needle-free vaccines.

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Check out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Your hand lotion is now also a vaccine. Hot damn

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Two fascinating papers just out in Nature @natureportfolio.bsky.social: www.nature.com/articles/s41... www.nature.com/articles/s41...

Illuminating thread by author ‪@mfgrp.bsky.social bsky.app/profile/mfgr...

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Brilliant work congrats to the authors!

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Awesome thread from @mfgrp.bsky.social about what might be the most amazing result you'll hear about in 2024: antigens stuck on the surface of the skin bacterium S. epidermidis generate a strong immune response in mouse.

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

A remarkable story from @mfgrp.bsky.social and colleagues: immunization via skin S. epidermidis generates systemic and mucosal antibody responses.

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

And in a Nature publication double-header, @mfgrp.bsky.social @stanford-chemh.bsky.social collaborates with Yasmine Belkaid and workers in this study reporting on local immune response including antibody generation in response to skin commensals: www.nature.com/articles/s41...

This is the most amazing thread since they did a similar thing to cure a cancer

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Wonder. Awe. Excitement. Very cool thread on a very cool finding. #IDSky

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Holy shit this is amazing!!! 🤯

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

discovery that a skin microbe can, without inflammation, induce a systemic B-cell response... and then engineering that microbe into a potent vaccine platform that can be applied as a topical cream. amazing work from @djenetbousbaine.bsky.social and @mfgrp.bsky.social! www.nature.com/articles/s41...

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

An amazing discovery, and a very informative and engaging thread. Could develop into a transformative new mode for efficient vaccination

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

one to savor over the holidays. also so cool to see how the directions of the work between @mfgrp.bsky.social and Belkaid labs diverged.

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Brilliant 🧵on a fascinating study demonstrating potent systemic and mucosal antibody responses to the common skin commensal Staph. epidermidis. Engineered S. epi expressing or displaying unrelated antigens elicited protective immunity,suggesting it could serve as topical vaccines. 💉

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Co-opting a skin commensal to design new vaccines! An amazingly creative and thoughtful new approach that integrates our knowledge of immune system responses. #ImmunoSky

Michael Fischbach@mfgrp.bsky.social · 2y ago

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Check out this bombshell publication by Michael Fischbach @mfgrp.bsky.social and coworkers @stanford-chemh.bsky.social @stanfordmedicine.bsky.social, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! 🤯 www.nature.com/articles/s41...

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

When Jerry Seinfeld is refining a joke, he works very hard to figure out what is the actual core funny part, so he knows what he can strip away. Same with your idea: you have to figure out what is its essence, to know what is the simplest form of it to work on. -Michael Fischbach @mfgrp.bsky.social

The goal is not to have a zero risk project; those are generally not worth working on. People with a good relationship with risk are definitely not avoiding it. They are super honest about it and they basically make it their goal to slowly chip away at it. nightscience.buzzsprout.com/1744020/epis...

66 | Michael Fischbach and the scientific decision tree - Night Science

In this episode, Stanford professor Michael Fischbach discusses insights from his course on how to choose meaningful research problems. Highlights include:- Invest time in problem selection: Spend mor...

nightscience.buzzsprout.com

Great interview with @stanford-chemh.bsky.social Institute Scholar @mfgrp.bsky.social

Itai Yanai@itaiyanai.bsky.social · 2y ago

The goal is not to have a zero risk project; those are generally not worth working on. People with a good relationship with risk are definitely not avoiding it. They are super honest about it and they basically make it their goal to slowly chip away at it. nightscience.buzzsprout.com/1744020/epis...